MRNA technology takes on the stomach flu: moderna launches norovirus vaccine trial
NCT ID NCT05992935
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests two experimental mRNA vaccines, mRNA-1403 and mRNA-1405, designed to prevent norovirus, a common cause of severe vomiting and diarrhea. Around 1,400 healthy adults aged 18 to 80 will receive either a vaccine or a placebo. The main goals are to check safety and measure the immune response.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- mRNA-1403 and mRNA-1405 vaccines
- What this could lead to
- If successful, this could lead to the first approved vaccine to prevent norovirus, a highly contagious stomach bug causing severe vomiting and diarrhea.
- What could go wrong
- This is an early phase 1/2 trial focused on safety and immune response, not yet proving the vaccine prevents illness. Side effects like injection site pain or fever are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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ARK Clinical Research, LLC
Long Beach, California, 90815, United States
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Accel Research Sites Network
Decatur, Georgia, 30030, United States
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Emeritus Research Camberwell
Camberwell, Australia
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Epic Medical Research, LLC
Red Oak, Texas, 75154, United States
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JBR Clinical Research
Salt Lake City, Utah, 84107, United States
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Johnson County Clin-Trials (JCCT)
Lenexa, Kansas, 66219, United States
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Nucleus Network
Melbourne, Australia
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Optimal Research
Peoria, Illinois, 61614, United States
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Research Centers of America
Hollywood, Florida, 33024, United States
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Rochester Clinical Research, Inc
Rochester, New York, 14609, United States
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Tekton Research, Inc - Longmont Center
Longmont, Colorado, 80501, United States
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Velocity Clinical Research
Sioux City, Iowa, 51106, United States
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Velocity Clinical Research
Rockville, Maryland, 20854, United States
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Velocity Clinical Research
Norfolk, Nebraska, 68701, United States
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Velocity Clinical Research
Omaha, Nebraska, 68134, United States
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Velocity Clinical Research - Boise
Meridian, Idaho, 83642, United States
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