New hope for hepatitis b patients: switching to TAF after relapse

NCT ID NCT04496882

Ongoing Disease control Sponsor: National Taiwan University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at 260 chronic hepatitis B patients who stopped their antiviral medication and then had a flare-up. They are switched to a drug called tenofovir alafenamide (TAF) to see if it can control the virus and improve liver health. The goal is to measure how many patients achieve undetectable virus levels and normal liver enzyme tests.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Tenofovir alafenamide (TAF), a drug to control hepatitis B virus
What this could lead to: If successful, this could show that switching to TAF is an effective way to manage hepatitis B flare-ups after stopping other antivirals, helping patients achieve viral suppression and liver health.
What could go wrong: This is a phase 4 trial, so the drug is already approved, but it may not work for everyone. The study is open-label and lacks a placebo group, which could bias results. Some patients may still experience side effects or incomplete viral control.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic hepatitis B virus infection hepatitis B virus infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC HEPATITIS B HEPATITIS B REACTIVATION

Contacts and locations

Locations

Buddhist Tzu Chi General Hospital, Da-Lin Branch

Chiayi City, Taiwan
Buddhist Tzu-Chi General Hospital Taipei Branch

Taipei, Taiwan
Chia-Yi Christian Hospital

Chiayi City, Taiwan
E-da hospital

Kaohsiung City, Taiwan
National Taiwan University Hospital

Taipei, 100, Taiwan
National Taiwan University Hospital ,Hsin-Chu Branch

Hsinchu, Taiwan
National Taiwan University Hospital, Yun-Lin branch

Douliu, Taiwan
Taipei City Hospital, Renai Branch

Taipei, Taiwan

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