Moderna launches first human test of mRNA vaccine against Epstein-Barr virus

NCT ID NCT05831111

Ongoing ⭐️ VACCINE ⭐️ Sponsor: ModernaTX, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 12, 2026 · Updated 3 times

Summary

This early-stage trial is testing an experimental mRNA vaccine called mRNA-1195 to see if it is safe and triggers an immune response against Epstein-Barr virus (EBV). The study involves 482 healthy adults aged 18 to 55, some of whom have had EBV before and some who have not. Participants will receive either the vaccine or a placebo, and researchers will monitor for side effects and measure antibody levels.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: mRNA-1195 (an mRNA vaccine)
What this could lead to: If successful, this could lead to a vaccine that prevents Epstein-Barr virus infection, which is linked to mononucleosis and some cancers.
What could go wrong: This is an early Phase 1 trial focused on safety, so it is too soon to know if the vaccine will work. The study is small and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Infections infectious mononucleosis viral infectious disease Epstein-Barr virus infection prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EPSTEIN-BARR VIRUS INFECTION

Contacts and locations

Locations

3A Research

Plano, Texas, 75093, United States
Alliance for Multispecialty Research, LLC

Knoxville, Tennessee, 37920, United States
Benchmark Research

Austin, Texas, 78705, United States
DM Clinical Research

Brookline, Massachusetts, 02445, United States
DM Clinical Research

Southfield, Michigan, 48076, United States
DM Clinical Research

Houston, Texas, 77065, United States
DM Clinical Research

Sugar Land, Texas, 77478, United States
DM Clinical Research

Tomball, Texas, 77375, United States
DM Clinical Research - Philadelphia

Philadelphia, Pennsylvania, 19107, United States
DM Clinical Research- Chicago

Melrose Park, Illinois, 60160, United States
Eximia Clinical Research

Raleigh, North Carolina, 27607, United States
Johnson County Clin-Trials, Inc (JCCT)

Lenexa, Kansas, 66219, United States
Las Vegas Clinical Trials, LLC

North Las Vegas, Nevada, 89030, United States
Marvel Clinical Research

Huntington Beach, California, 92647, United States
Noble Clinical Research

Tucson, Arizona, 85704, United States
Optimal Research

Peoria, Illinois, 61614, United States
Pinnacle Research Group, LLC

Anniston, Alabama, 36207, United States
Rochester Clinical Research, Inc

Rochester, New York, 14609, United States
Suncoast Research Group, LLC

Miami, Florida, 33135, United States
Tekton Research

Longmont, Colorado, 80501, United States
Tekton Research

Moore, Oklahoma, 73160, United States
Tekton Research

Oklahoma City, Oklahoma, 73134, United States
Tekton Research Inc.

Austin, Texas, 78745, United States
Tekton Research, Inc

Edmond, Oklahoma, 73013, United States
University of Massachusetts Chan Medical School

Worcester, Massachusetts, 01655, United States
Velocity Clinical Research

Savannah, Georgia, 31406, United States
Velocity Clinical Research

Sioux City, Iowa, 51106, United States
Velocity Clinical Research

Rockville, Maryland, 20854, United States
Velocity Clinical Research

Grand Island, Nebraska, 68803, United States
Velocity Clinical Research

Hastings, Nebraska, 68901, United States
Velocity Clinical Research

Lincoln, Nebraska, 68510, United States
Velocity Clinical Research

Norfolk, Nebraska, 68701, United States
Velocity Clinical Research

Omaha, Nebraska, 68134, United States
Velocity Clinical Research

Binghamton, New York, 13905, United States

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