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Twice-Yearly shot could revolutionize HIV prevention for young women

NCT ID NCT04994509

Ongoing Prevention Sponsor: Gilead Sciences Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested two ways to prevent HIV in over 5,000 adolescent girls and young women at risk. One group received a long-acting shot every six months, while others took daily pills. The goal was to see how well each method works to keep participants HIV-free.

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Conditions

The condition(s) this trial relates to.

HIV infectious disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PRE-EXPOSURE PROPHYLAXIS OF HIV INFECTION

Contacts and locations

Locations

  • AMBSO Masaka Clinical Research site

    Kyotera- Masaka Region, Uganda

  • Africa Health Research Institute

    Mtubatuba, 3935, South Africa

  • Botha's Hill Clinical Research Site, HIV Prevention Research Unit

    Durban, 3660, South Africa

  • CAPRISA Umlazi Clinical Research Site

    Umlazi, 4066, South Africa

  • CAPRISA Vulindlela Clinical Research Site

    Durban, 4001, South Africa

  • CAPRISA eThekwini Clinical Research Site

    Durban, 4001, South Africa

  • Chatsworth Clinical Research Site, South African Medical Research Council, HIV and Other Infectious Disease Research Unit

    Kwa Zulu Natal, South Africa

  • Desmond Tutu Health Foundation - Masiphumelele Research Office

    Sunnydale, 7705, South Africa

  • Desmond Tutu Health Foundation Clinical Trials Unit

    Cape Town, 7925, South Africa

  • Emavundleni Research Centre

    Cape Town, 7750, South Africa

  • FPD-DTHF Ndevana Community Research Site

    Vincent, 5217, South Africa

  • Madibeng Centre for Research

    Brits, 2500, South Africa

  • Makerere University- John Hopkins University (MU-JHU) Mityana Research Site (MU-JHU) Care Ltd

    Mityana Town, Uganda

  • Makerere-Kalangala Clinical Research site

    Kalangala, Uganda

  • MatCH Research Unit, Suite 1112, 11th Floor

    Durban, 4001, South Africa

  • Perinatal HIV Research Unit (PHRU) Soweto Kliptown

    Kliptown, 1809, South Africa

  • Phoenix Clinical Research Site, South African Medical Research Council, HIV and Other Infectious Disease Research Unit

    Kwa Zulu Natal, 4061, South Africa

  • Qhakaza Mbokodo Research Clinic

    Ladysmith, 3370, South Africa

  • Setshaba Research Centre

    Gauteng, 152, South Africa

  • Synergy Biomed Research Institute (SBRI)

    East London, South Africa

  • The Aurum Institute: Gavin J Churchyard Legacy Centre, Klerksdorp Clinical Research Centre

    Klerksdorp, 2571, South Africa

  • The Aurum Institute: Pretoria Clinical Research Centre

    Pretoria, 0087, South Africa

  • The Aurum Institute: Rustenburg Clinical Research Centre

    Rustenburg, 299, South Africa

  • The Aurum Institute: Tembisa Clinical Research Centre

    Tembisa, 1632, South Africa

  • Tongaat Clinical Research Site, South African Medical Research Council, HIV and Other Infectious Disease Research Unit

    Kwa Zulu Natal, 4400, South Africa

  • Verulam Clinical Research Site, South African Medical Research Council, HIV and Other Infectious Disease Research Unit

    Kwa Zulu Natal, 4340, South Africa

  • Vuka Research Clinic

    Cape Town, 7784, South Africa

  • Wits Reproductive Health & HIV Institute (Wits RHI)

    Johannesburg, 2038, South Africa

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