Twice-a-Year shot could revolutionize HIV prevention

NCT ID NCT06513312

First seen Nov 01, 2025 · Last updated Apr 09, 2026 · Updated 15 times

Summary

This study is testing whether a new injection given just twice a year can prevent HIV infection as effectively as daily pills. Researchers are comparing the injection (lenacapavir) to the standard daily pill (Truvada) in people at increased risk of getting HIV. The study will track how well people stick with each method, monitor safety, and see how the injection moves through the body over one year.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • APHP Bichat Claude-Bernard Hospital

    Paris, 75018, France

  • APHP Hopital Saint-Antoine

    Paris, 75012, France

  • Axess Sexual Health, Liverpool University Hospitals NHS Trust

    Liverpool, L7 8YE, United Kingdom

  • CHU Nice Archet

    Nice, 6202, France

  • Caldecot Centre, Kings College Hospital, Kings College Hospital NHS Foundation Trust

    London, SE5 9RS, United Kingdom

  • Chelsea and Westminster Hospital NHS Foundation Trust, Clinical Research Facility, Chelsea and Westminster Hospital

    London, SW10 9NH, United Kingdom

  • Clinical Research Facility, University Hospitals Sussex NHS Foundation Trust

    Brighton, BN2 3EW, United Kingdom

  • Grahame Hayton Unit, Ambrose King Centre, Royal London Hospital, Barts Health NHS Trust

    London, E11BB, United Kingdom

  • Homerton Healthcare NHS Foundation Trust, Homerton University Hospital

    London, E9 6SR, United Kingdom

  • Hopital Avicenne

    Bobigny, 93000, France

  • Hopital Europeen Marseille

    Marseille, 13006, France

  • Hopital Saint Louis - Assistance Publique des Hopitaux de Paris

    Paris, 75010, France

  • Manchester University NS Foundation Trust

    Manchester, M13 0FH, United Kingdom

  • University Hospitals Birmingham NHS Foundation Trust, Birmingham Heartlands Hospital

    Birmingham, B9 5SS, United Kingdom

Conditions

Explore the condition pages connected to this study.