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Could a shot every 6 months replace daily HIV prevention pills?

NCT ID NCT06513312

Ongoing Prevention Sponsor: Gilead Sciences Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new option for preventing HIV: a shot given under the skin every 6 months, called lenacapavir. It compares how well people stick with the shot versus taking a daily pill (Truvada). About 268 people at higher risk for HIV will take part. The goal is to see if the shot is easier to use, safe, and works as well as daily pills.

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Conditions

The condition(s) this trial relates to.

HIV infectious disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PRE-EXPOSURE PROPHYLAXIS OF HIV INFECTION

Contacts and locations

Locations

  • APHP Bichat Claude-Bernard Hospital

    Paris, 75018, France

  • APHP Hopital Saint-Antoine

    Paris, 75012, France

  • Axess Sexual Health, Liverpool University Hospitals NHS Trust

    Liverpool, L7 8YE, United Kingdom

  • CHU Nice Archet

    Nice, 6202, France

  • Caldecot Centre, Kings College Hospital, Kings College Hospital NHS Foundation Trust

    London, SE5 9RS, United Kingdom

  • Chelsea and Westminster Hospital NHS Foundation Trust, Clinical Research Facility, Chelsea and Westminster Hospital

    London, SW10 9NH, United Kingdom

  • Clinical Research Facility, University Hospitals Sussex NHS Foundation Trust

    Brighton, BN2 3EW, United Kingdom

  • Grahame Hayton Unit, Ambrose King Centre, Royal London Hospital, Barts Health NHS Trust

    London, E11BB, United Kingdom

  • Homerton Healthcare NHS Foundation Trust, Homerton University Hospital

    London, E9 6SR, United Kingdom

  • Hopital Avicenne

    Bobigny, 93000, France

  • Hopital Europeen Marseille

    Marseille, 13006, France

  • Hopital Saint Louis - Assistance Publique des Hopitaux de Paris

    Paris, 75010, France

  • Manchester University NS Foundation Trust

    Manchester, M13 0FH, United Kingdom

  • University Hospitals Birmingham NHS Foundation Trust, Birmingham Heartlands Hospital

    Birmingham, B9 5SS, United Kingdom

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