Can the HPV vaccine protect those with a weak immune system?
NCT ID NCT03519464
First seen Jun 24, 2026 · Last updated Aug 14, 2026 · Updated 3 times
Summary
This study tests whether the HPV vaccine Gardasil 9 can trigger an immune response in people with idiopathic CD4 T cell lymphocytopenia (ICL), a rare condition that weakens the immune system. About 54 adults with ICL and some healthy volunteers will receive three doses of the vaccine over six months. Researchers will measure antibody levels to see if the vaccine helps protect against HPV-related diseases.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Gardasil 9 (HPV vaccine)
- What this could lead to
- If it works, this could show that the HPV vaccine can protect people with ICL from HPV-related diseases like warts and cancers.
- What could go wrong
- This is a small, early-phase study with only 54 participants, so results may not apply to everyone. The immune system in ICL is weak, so the vaccine may not work as well as in healthy people.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States