Could a cancer drug help cure hepatitis b? new trial launches
NCT ID NCT06357806
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This pilot study tests whether adding a PD-1 antibody (sintilimab) and pegylated interferon to standard antiviral therapy can help people with chronic hepatitis B lose the hepatitis B surface antigen (HBsAg), a key step toward a functional cure. The trial will enroll 45 adults who have been on antivirals for at least a year and have low but detectable HBsAg levels. Researchers will monitor safety and how many participants clear HBsAg at 24 and 48 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Sintilimab (PD-1 antibody) combined with pegylated interferon-α2b
What this could lead to
If successful, this combination could help more people with chronic hepatitis B achieve a functional cure, meaning the virus is suppressed without lifelong medication.
What could go wrong
This is a small, early pilot study with only 45 participants, so results may not apply broadly. The treatment can cause immune-related side effects, and it is not yet known if it will work better than standard care.
Disclaimer
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the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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the Fifth Medical Center, Chinese PLA General Hospital
Beijing, Beijing Municipality, 100039, China