Hepatitis b breakthrough? study checks if bepirovirsen response lasts

NCT ID NCT04954859

Ongoing Knowledge-focused Sponsor: GlaxoSmithKline Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study follows about 360 people with chronic hepatitis B who had a good response to the experimental drug bepirovirsen in earlier trials. No new drug is given; researchers simply monitor whether the response lasts over time. Participants may or may not continue standard antiviral therapy. The goal is to see if a short treatment can lead to long-term disease control.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to

If successful, this study could show that a short course of bepirovirsen leads to long-lasting control of hepatitis B without needing ongoing medication.

What could go wrong

This is an observational follow-up, not a new treatment test. It only includes people who already responded, so results may not apply to all hepatitis B patients. The number of participants is small, and long-term durability is uncertain.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

hepatitis B virus infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEPATITIS B

Contacts and locations

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Locations

GSK Investigational Site

Sacramento, California, 95817, United States
GSK Investigational Site

San Jose, California, 95128, United States
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Colorado Springs, Colorado, 80907, United States
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Boston, Massachusetts, 02114, United States
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Detroit, Michigan, 48202, United States
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La Plata, Buenos Aires, B1902AWL, Argentina
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Buenos Aires, C1181ACH, Argentina
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Buenos Aires, C1425AGC, Argentina
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Rosario, 2000, Argentina
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Santa Fe, 3000, Argentina
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Herston, Queensland, 4029, Australia
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Fitzroy, Victoria, 3065, Australia
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Aracaju, Sergipe, 49055-000, Brazil
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Campinas, 13060-803, Brazil
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Curitiba, 30140-073, Brazil
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Manaus, 69040000, Brazil
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São Paulo, 05403-000, Brazil
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Vila Mariana, 04121-000, Brazil
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Plovdiv, 4000, Bulgaria
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Sliven, 8800, Bulgaria
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Sofia, 1431, Bulgaria
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Sofia, 1463, Bulgaria
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Sofia, 1606, Bulgaria
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Varna, 9010, Bulgaria
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Calgary, Alberta, T2N 4Z6, Canada
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Victoria, British Columbia, V8R 6R3, Canada
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Toronto, Ontario, M5G 2C4, Canada
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Montreal, Quebec, H2X 0A9, Canada
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Montreal, Quebec, H4A 3J1, Canada
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Québec, Quebec, G1V 4G2, Canada
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Beijing, 100015, China
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Beijing, 100039, China
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Beijing, 100050, China
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Chengdu, 610041, China
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Chengdu, 610072, China
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Chongqing, 400042, China
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Fuzhou, 350028, China
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Guangzhou, 510000, China
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Guangzhou, 510440, China
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Guangzhou, 510630, China
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Hangzhou, 310014, China
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Hangzhou, 310022, China
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Kunming, 650021, China
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Liuzhou, China
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Shanghai, 200025, China
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Shanghai, 200040, China
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Shanghai, 201508, China
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Shenzhen, 518112, China
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Tianjin, 300000, China
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Ürümqi, 830054, China
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Wuhan, 430030, China
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Xi'an, 710061, China
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Xiamen, 361015, China
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Zhenjiang, China
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Zunyi, 563114, China
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Clichy, 92110, France
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Lyon, 69317, France
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Paris, France
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Pessac, 33604, France
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Rennes, 35000, France
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Strasbourg, 67200, France
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Düsseldorf, North Rhine-Westphalia, 40225, Germany
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Berlin, 12157, Germany
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Berlin, 12163, Germany
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Frankfurt am Main, 60329, Germany
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Hamburg, 20146, Germany
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Athens, 10676, Greece
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Athens, 11527, Greece
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Heraklion, 711 10, Greece
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Kowloon, Hong Kong
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Pokfulam, Hong Kong
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Budapest, 1097, Hungary
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Belagavi, 590010, India
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Coimbatore, 641005, India
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Hyderabad, India
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Kanchan Bagh Hyderabad, 40000, India
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Mumbai, 400008, India
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Mumbai, 400012, India
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Mumbai, 400022, India
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New Delhi, 110070, India
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Pune, 411001, India
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Surat, 395002, India
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Bergamo, 24127, Italy
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Milan, 20122, Italy
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Milan, 20157, Italy
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Modena, 40126, Italy
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Naples, 80131, Italy
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Palermo, 90127, Italy
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Pisa, 56124, Italy
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Gifu, 500-8717, Japan
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Gifu, 503-8502, Japan
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Hiroshima, 730-8619, Japan
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Hiroshima, 734-8551, Japan
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Hokkaido, 006-0811, Japan
GSK Investigational Site

Ishikawa, 920-8650, Japan
GSK Investigational Site

Kagawa, 760-8557, Japan
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Kumamoto, 860-8556, Japan
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Kumamoto, 862-8655, Japan
GSK Investigational Site

Miyagi, 980-8574, Japan
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Niigata, 950-1104, Japan
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Osaka, 565-0871, Japan
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Tokyo, 113-8519, Japan
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Tokyo, 113-8603, Japan
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Tokyo, 180-8610, Japan
GSK Investigational Site

Yamaguchi, 750-0061, Japan
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Kuala Terengganu, 20400, Malaysia
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Auckland, 01042, New Zealand
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Panama City, 7196, Panama
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Cebu City, 6000, Philippines
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Silang, 4118, Philippines
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Gdansk, 80-405, Poland
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Krakow, 31-202, Poland
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Lublin, Poland
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Mysłowice, 41-400, Poland
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Żychlin, 62-571, Poland
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Łańcut, 37-100, Poland
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Bucharest, 020125, Romania
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Bucharest, 021105, Romania
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Bucharest, 030303, Romania
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Craiova Dolj, 417307, Romania
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Galati, 800179, Romania
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Oradea, 410469, Romania
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Chelyabinsk, 454052, Russia
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Moscow, 121170, Russia
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Novosibirsk, 630099, Russia
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Saint Petersburg, 190103, Russia
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Saint Petersburg, 191167, Russia
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Samara, 443063, Russia
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Красноярск, 660049, Russia
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Singapore, 119074, Singapore
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Singapore, 169608, Singapore
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Singapore, 529889, Singapore
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Durban, 4091, South Africa
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Johannesburg, 1830, South Africa
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Ansan-si Gyenggi-do, 15355, South Korea
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Busan, 47392, South Korea
GSK Investigational Site

Pusan, 49241, South Korea
GSK Investigational Site

Seoul, 03312, South Korea
GSK Investigational Site

Seoul, 05505, South Korea
GSK Investigational Site

Seoul, 08308, South Korea
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HebrOn, 08035, Spain
GSK Investigational Site

León, 24080, Spain
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Madrid, 28031, Spain
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Santander, 39008, Spain
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Valencia, 46026, Spain
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Vigo, 36071, Spain
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Kaohsiung City, 807, Taiwan
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Kaohsiung City, 824, Taiwan
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Kaohsiung City, 833, Taiwan
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Taichung, 40447, Taiwan
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Tainan, 70403, Taiwan
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Taipei, 10002, Taiwan
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Taipei County, 104, Taiwan
GSK Investigational Site

Taoyuan, 333, Taiwan
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Bangkok, 10330, Thailand
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Bangkok, 10400, Thailand
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Chiang Mai, 50200, Thailand
GSK Investigational Site

Kho Hong Hat Yai, 90110, Thailand
GSK Investigational Site

Cottingham, HU16 5JQ, United Kingdom
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Liverpool, L7 8XP, United Kingdom
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London, SW9 8RR, United Kingdom
GSK Investigational Site

London, WC1E 6JB, United Kingdom
GSK Investigational Site

Plymouth, PL68DH, United Kingdom