Hepatitis b drug holiday: can stopping treatment lead to a cure?

NCT ID NCT04431245

Ongoing Knowledge-focused Sponsor: The University of Hong Kong Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows 54 people with chronic hepatitis B who stop taking their antiviral medication after at least three years. Researchers will closely monitor their immune system and virus levels to see what happens during a flare. The goal is to learn whether a controlled flare might help the body fight off the virus for good.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could help doctors understand when it might be safe to stop antiviral therapy for chronic hepatitis B, potentially reducing long-term medication use.
What could go wrong: This is an observational study with only 54 participants. It does not test a new treatment, and stopping antivirals carries a risk of serious liver flare. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic hepatitis B virus infection hepatitis B virus infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC HEPATITIS B

Contacts and locations

Locations

Man Fung Yuen

Hong Kong, Please Select One ..., Hong Kong

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