Hepatitis b drug holiday: can stopping treatment lead to a cure?
NCT ID NCT04431245
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study follows 54 people with chronic hepatitis B who stop taking their antiviral medication after at least three years. Researchers will closely monitor their immune system and virus levels to see what happens during a flare. The goal is to learn whether a controlled flare might help the body fight off the virus for good.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this study could help doctors understand when it might be safe to stop antiviral therapy for chronic hepatitis B, potentially reducing long-term medication use.
What could go wrong
This is an observational study with only 54 participants. It does not test a new treatment, and stopping antivirals carries a risk of serious liver flare. Results may not apply to all patients.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Man Fung Yuen
Hong Kong, Please Select One ..., Hong Kong