Weekly HIV pill could replace daily doses

NCT ID NCT05052996

Ongoing Disease control Sponsor: Gilead Sciences Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests if a once-weekly combination of two oral drugs, islatravir and lenacapavir, can keep HIV under control in people whose virus is already suppressed. 142 participants switched from their daily HIV pill to this weekly regimen. The main goal is to see if the virus stays undetectable after 24 weeks. This is not a cure, but aims to make HIV management easier with fewer doses.

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Conditions

The condition(s) this trial relates to.

HIV infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV -1 INFECTION

Contacts and locations

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Locations

AIDS Arms Inc

Dallas, Texas, 75208, United States
AXCES Research Group

Santa Fe, New Mexico, 87505, United States
AccessHealth MA

Boston, Massachusetts, 02129, United States
Atlanta ID Group, PC

Atlanta, Georgia, 30309, United States
BIOS Clinical Research

Palm Springs, California, 92262, United States
Be Well Medical Center

Berkley, Michigan, 48072, United States
Boston Medical Center

Boston, Massachusetts, 02118, United States
CAN Community Health Care, Inc.

Fort Lauderdale, Florida, 33316, United States
Central Texas Clinical Research, LLC

Austin, Texas, 78705, United States
Chatham County Health Department

Savannah, Georgia, 31401, United States
Community Health Care

Tacoma, Washington, 98405, United States
Emory University Hospital Midtown Infectious Disease Clinic

Atlanta, Georgia, 30308, United States
Floridian Clinical Research

Miami Lakes, Florida, 33016, United States
Hennepin Healthcare HCMC

New Brighton, Minnesota, 55112, United States
Hoag Medical Group - Newport Beach

Newport Beach, California, 92663, United States
Howard Brown Health Center

Chicago, Illinois, 60613, United States
Huntridge Family Clinic

Las Vegas, Nevada, 89104, United States
ID Care

Hillsborough, New Jersey, 08844, United States
Indiana CTSI Clinical Research Center

Indianapolis, Indiana, 46202, United States
JEM Research Institute

Lake Worth, Florida, 33462, United States
Jacobi Medical Center

The Bronx, New York, 10461, United States
John A. Burns School of Medicine, University of Hawaii Clinics at Kaka'ako

Honolulu, Hawaii, 96813, United States
Metro Infectious Disease Consultants

Decatur, Georgia, 30033, United States
Midway Immunology and Research Center

Ft. Pierce, Florida, 34982, United States
Mills Clinical Research

Los Angeles, California, 90069, United States
MultiCare Rockwood Main Clinic

Spokane, Washington, 99202, United States
NC TraCS Institute - CTRC: University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, 27599, United States
New York-Presbyterian Queens

Flushing, New York, 11355, United States
North Texas Infectious Diseases Consultants, P.A.

Dallas, Texas, 75246, United States
Northstar Healthcare

Chicago, Illinois, 60657, United States
Optimus Medical Group

San Francisco, California, 94102, United States
Orlando Immunology Center

Orlando, Florida, 32803, United States
Pacific Oaks Medical Group

Beverly Hills, California, 90211, United States
Penn Medicine: Perelman Center for Advanced Medicine at the Hospital of the University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
Peter Shalit, M.D.

Seattle, Washington, 98104, United States
Philadelphia FIGHT Community Health Centers

Philadelphia, Pennsylvania, 19107, United States
Public Health Institute at Denver Health

Denver, Colorado, 80204, United States
Ruane Clinical Research Group, Inc

Los Angeles, California, 90036, United States
Schiff Center for Liver Diseases/University of Miami

Miami, Florida, 33136, United States
Southampton Healthcare, Inc.

St Louis, Missouri, 63139, United States
The Crofoot Research Center, INC

Houston, Texas, 77098, United States
The George Washington University Medical Faculty Associates Inc.

Washington D.C., District of Columbia, 20037, United States
Vivent Health

Denver, Colorado, 80246, United States
Washington Health Institute

Washington D.C., District of Columbia, 20017, United States

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