Peer support could boost HIV med adherence and curb substance use
NCT ID NCT05933226
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a program called Khanya, where trained peers (people with lived substance use experience) help HIV patients stick to their medication and reduce drug or alcohol use. The program is offered in steps: a basic version first, then a more intensive one if needed. Researchers will compare it to usual care over 12 months in South African primary care clinics. About 160 adults with HIV who have trouble taking their medication and have moderate-to-high substance use risk are taking part.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Khanya (peer-delivered behavioral intervention)
- What this could lead to
- If it works, this could provide a low-cost, scalable way to improve HIV medication adherence and reduce substance use in primary care settings.
- What could go wrong
- This is a relatively small trial (160 participants) testing a behavioral intervention, so results may not apply broadly. The intervention relies on peer counselors, which may vary in effectiveness.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Cape Town
Cape Town, Western Cape, South Africa
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