Can less radiation be just as effective for HPV-Linked throat cancer?

NCT ID NCT01898494

Ongoing Disease control Sponsor: ECOG-ACRIN Cancer Research Group Source: ClinicalTrials.gov ↗

First seen Apr 06, 2026 · Last updated Apr 27, 2026 · Updated 1 time

Summary

This study looks at whether giving a lower dose of radiation after surgery works as well as the standard dose for people with HPV-positive throat cancer that has spread but can still be removed. About 519 adults with stage III or IVA disease took part. The goal is to see if reducing radiation can control the cancer while causing fewer side effects.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Boston Medical Center

Boston, Massachusetts, 02118, United States
Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States
Case Western Reserve University

Cleveland, Ohio, 44106, United States
City of Hope Comprehensive Cancer Center

Duarte, California, 91010, United States
Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
Dana-Farber Cancer Institute

Boston, Massachusetts, 02115, United States
Dartmouth Hitchcock Medical Center

Lebanon, New Hampshire, 03756, United States
Duke University Medical Center

Durham, North Carolina, 27710, United States
Emory University Hospital Midtown

Atlanta, Georgia, 30308, United States
Emory University/Winship Cancer Institute

Atlanta, Georgia, 30322, United States
Florida Hospital Orlando

Orlando, Florida, 32803, United States
Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111, United States
Froedtert and the Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Greater Baltimore Medical Center

Baltimore, Maryland, 21204, United States
Henry Ford Hospital

Detroit, Michigan, 48202, United States
Inova Fairfax Hospital

Falls Church, Virginia, 22042, United States
Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, 21287, United States
Kaiser Permanente Oakland-Broadway

Oakland, California, 94611, United States
M D Anderson Cancer Center

Houston, Texas, 77030, United States
Mayo Clinic in Arizona

Scottsdale, Arizona, 85259, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Memorial Sloan-Kettering Cancer Center

New York, New York, 10065, United States
Mercy Hospital Springfield

Springfield, Missouri, 65804, United States
Montefiore Medical Center - Moses Campus

The Bronx, New York, 10467-2490, United States
Nebraska Methodist Hospital

Omaha, Nebraska, 68114, United States
Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States
Oregon Health and Science University

Portland, Oregon, 97239, United States
Penrose-Saint Francis Healthcare

Colorado Springs, Colorado, 80907, United States
PinnacleHealth Cancer Center-Community Campus

Harrisburg, Pennsylvania, 17109, United States
Porter Adventist Hospital

Denver, Colorado, 80210, United States
Providence Portland Medical Center

Portland, Oregon, 97213, United States
Rocky Mountain Cancer Centers-Boulder

Boulder, Colorado, 80304, United States
Rocky Mountain Cancer Centers-Penrose

Colorado Springs, Colorado, 80907, United States
Sentara Cancer Institute at Sentara CarePlex Hospital

Hampton, Virginia, 23666, United States
Sentara Hospitals

Norfolk, Virginia, 23507, United States
Sentara Virginia Beach General Hospital

Virginia Beach, Virginia, 23454, United States
Stanford Cancer Institute

Palo Alto, California, 94304, United States
Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States
UCLA / Jonsson Comprehensive Cancer Center

Los Angeles, California, 90095, United States
UCSF Medical Center-Mount Zion

San Francisco, California, 94115, United States
UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, 75390, United States
University of Alabama at Birmingham Cancer Center

Birmingham, Alabama, 35233, United States
University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205, United States
University of Iowa/Holden Comprehensive Cancer Center

Iowa City, Iowa, 52242, United States
University of Kansas Cancer Center

Kansas City, Kansas, 66160, United States
University of Kentucky/Markey Cancer Center

Lexington, Kentucky, 40536, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, 33136, United States
University of Miami Sylvester Comprehensive Cancer Center at Deerfield Beach

Deerfield Beach, Florida, 33442, United States
University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States
University of New Mexico

Albuquerque, New Mexico, 87102, United States
University of Pennsylvania/Abramson Cancer Center

Philadelphia, Pennsylvania, 19104, United States
University of Pittsburgh Cancer Institute (UPCI)

Pittsburgh, Pennsylvania, 15232, United States
University of Virginia Cancer Center

Charlottesville, Virginia, 22908, United States
University of Washington Medical Center

Seattle, Washington, 98195, United States
University of Wisconsin Hospital and Clinics

Madison, Wisconsin, 53792, United States
Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, 37232, United States
Yale University

New Haven, Connecticut, 06520, United States
Zablocki Veterans Administration Medical Center

Milwaukee, Wisconsin, 53295, United States

Conditions

Explore the condition pages connected to this study.

HUMAN PAPILLOMA VIRUS INFECTION STAGE III SQUAMOUS CELL CARCINOMA OF THE OROPHARYNX STAGE IVA SQUAMOUS CELL CARCINOMA OF THE OROPHARYNX STAGE IVA SQUAMOUS CELL CARCINOMA OF THE OROPHARYNX STAGE IVB SQUAMOUS CELL CARCINOMA OF THE OROPHARYNX STAGE IVB SQUAMOUS CELL CARCINOMA OF THE OROPHARYNX