Ecog-acrin Cancer Research Group

This study is testing whether a smart pillbox, combined with text message reminders, can help people with advanced breast cancer remember to take their oral medication correctly. The goal is to see if this technology helps patients stick to their complex treatment schedule better…

This study aims to find out which of two drug treatments works better for people with an advanced form of thyroid cancer that has a specific genetic change (BRAF V600E) and has stopped responding to standard therapies. Researchers will compare a two-drug combination (dabrafenib a…

This study is for people with colon cancer that has spread to the liver and cannot be removed by surgery. It tests if adding a special pump that delivers chemotherapy directly to the liver helps patients live longer than standard chemotherapy alone. The pump is already FDA-approv…

This study is for people diagnosed with high-risk smoldering myeloma, a condition where abnormal blood cells are present but haven't yet caused active cancer symptoms. The goal is to see if adding a newer immunotherapy drug (daratumumab) to a standard two-drug treatment (lenalido…

This study is testing whether giving chemotherapy before surgery helps preserve important facial structures like the eye socket and skull base in patients with advanced nasal and sinus cancer. It compares two approaches: one group gets surgery followed by radiation, while the oth…

This study is testing if adding a chemotherapy drug (paclitaxel) directly into the abdominal cavity, along with standard IV chemotherapy, works better than standard IV chemotherapy alone for people with advanced stomach cancer that has spread to the lining of the abdomen. Partici…

This large, late-stage trial is comparing two drug combinations for people newly diagnosed with a type of blood cancer called multiple myeloma. It will test if adding a fourth drug (bortezomib) to a standard three-drug regimen helps patients live longer and keeps the cancer from …

This large study is testing if using a PET scan to guide treatment decisions helps control prostate cancer that returns after surgery. For about 800 men, the scan will determine if they receive standard radiation and hormone therapy alone, or if stronger drug therapy and targeted…

This study is for people who have had surgery for stage III-IVA head and neck cancer. It tests whether adding the chemotherapy drug cisplatin to standard radiation treatment is better at preventing the cancer from coming back than radiation alone. The study also uses a genetic te…

This study is testing if advanced imaging techniques can help doctors better understand brain scans of people with glioblastoma, a serious brain cancer. After standard radiation treatment, it can be hard to tell on a regular MRI if the tumor is actually growing or if the changes …

This study tests if a financial counseling program helps cancer patients manage treatment costs and reduces stress. It will enroll 760 adults recently diagnosed with solid tumors. Participants will be randomly assigned to receive either standard information or a series of persona…

This research aims to understand how social factors and genetics affect long-term health in young adults who have survived Hodgkin or Non-Hodgkin lymphoma. The study will follow 2,000 survivors for two years, collecting blood samples and survey data about their quality of life, s…