Chemo before surgery may save eye and skull in sinus cancer patients

NCT ID NCT03493425

Recruiting now Disease control Sponsor: ECOG-ACRIN Cancer Research Group Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving chemotherapy before surgery and radiation can help preserve the eye and skull base in people with advanced nasal and sinus cancer. About 82 participants will either get chemo first or go straight to surgery and radiation. The goal is to see if the chemo shrinks the tumor enough to avoid removing the eye or skull base.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: chemotherapy (docetaxel, cisplatin, carboplatin)
What this could lead to: If it works, this approach could help more people with advanced sinus cancer keep their eye and skull base structures while still treating the cancer effectively.
What could go wrong: This is a phase 2 trial with only 82 participants, so results are preliminary. Chemotherapy can cause side effects like infection, fatigue, and organ damage, and it may not improve outcomes over standard treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

nasal cavity and paranasal sinus squamous cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

STAGE III NASAL CAVITY AND PARANASAL SINUS SQUAMOUS CELL CARCINOMA AJCC V6 AND V7 STAGE IVA NASAL CAVITY AND PARANASAL SINUS SQUAMOUS CELL CARCINOMA AJCC V7

Contacts and locations

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Locations

Allegiance Health
RECRUITING

Jackson, Michigan, 49201, United States

Contact Email: •••••@•••••
Ascension Via Christi - Pittsburg
ACTIVE_NOT_RECRUITING

Pittsburg, Kansas, 66762, United States
Banner University Medical Center - Tucson
RECRUITING

Tucson, Arizona, 85719, United States
Benefis Healthcare- Sletten Cancer Institute
RECRUITING

Great Falls, Montana, 59405, United States

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Billings Clinic Cancer Center
RECRUITING

Billings, Montana, 59101, United States

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Bozeman Deaconess Hospital
RECRUITING

Bozeman, Montana, 59715, United States

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Broadlawns Medical Center
RECRUITING

Des Moines, Iowa, 50314, United States
Carle Cancer Center
RECRUITING

Urbana, Illinois, 61801, United States

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Carle Physician Group-Effingham
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Effingham, Illinois, 62401, United States

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Carle Physician Group-Mattoon/Charleston
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Mattoon, Illinois, 61938, United States

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Carle on Vermilion
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Danville, Illinois, 61832, United States

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Central Care Cancer Center - Bolivar
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Bolivar, Missouri, 65613, United States
Central Care Cancer Center - Garden City
RECRUITING

Garden City, Kansas, 67846, United States
Central Care Cancer Center - Great Bend
RECRUITING

Great Bend, Kansas, 67530, United States
Community Medical Hospital
RECRUITING

Missoula, Montana, 59804, United States

Contact Email: •••••@•••••
CoxHealth South Hospital
RECRUITING

Springfield, Missouri, 65807, United States
Delbert Day Cancer Institute at PCRMC
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Rolla, Missouri, 65401, United States

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Diagnostic and Treatment Center
RECRUITING

Weston, Wisconsin, 54476, United States

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Emory Proton Therapy Center
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Atlanta, Georgia, 30308, United States
Emory University Hospital Midtown
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Atlanta, Georgia, 30308, United States
Emory University Hospital/Winship Cancer Institute
RECRUITING

Atlanta, Georgia, 30322, United States
Freeman Health System
RECRUITING

Joplin, Missouri, 64804, United States
Good Samaritan Regional Health Center
RECRUITING

Mount Vernon, Illinois, 62864, United States
Great Falls Clinic
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Great Falls, Montana, 59405, United States

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Heartland Regional Medical Center
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Saint Joseph, Missouri, 64506, United States
Henry Ford Cancer Institute-Downriver
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Brownstown, Michigan, 48183, United States

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Henry Ford Hospital
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Detroit, Michigan, 48202, United States

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Henry Ford Macomb Health Center - Shelby Township
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Shelby, Michigan, 48315, United States
Henry Ford Macomb Hospital-Clinton Township
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Clinton Township, Michigan, 48038, United States

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Henry Ford Medical Center-Columbus
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Novi, Michigan, 48377, United States

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Henry Ford Medical Center-Fairlane
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Dearborn, Michigan, 48126, United States

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Henry Ford West Bloomfield Hospital
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West Bloomfield, Michigan, 48322, United States

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Idaho Urologic Institute-Meridian
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Meridian, Idaho, 83642, United States
Inova Fairfax Hospital
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Falls Church, Virginia, 22042, United States
Inova Schar Cancer Institute
RECRUITING

Fairfax, Virginia, 22031, United States
Iowa Lutheran Hospital
RECRUITING

Des Moines, Iowa, 50316, United States
Iowa Methodist Medical Center
RECRUITING

Des Moines, Iowa, 50309, United States
Kalispell Regional Medical Center
RECRUITING

Kalispell, Montana, 59901, United States

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Kootenai Clinic Cancer Services - Post Falls
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Post Falls, Idaho, 83854, United States

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Kootenai Health - Coeur d'Alene
RECRUITING

Coeur d'Alene, Idaho, 83814, United States

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Lawrence Memorial Hospital
ACTIVE_NOT_RECRUITING

Lawrence, Kansas, 66044, United States
Lenox Hill Hospital
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New York, New York, 10021, United States
Long Island Jewish Medical Center
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New Hyde Park, New York, 11040, United States
Marshfield Clinic Stevens Point Center
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Stevens Point, Wisconsin, 54482, United States

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Marshfield Clinic-Minocqua Center
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Minocqua, Wisconsin, 54548, United States

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Marshfield Clinic-Wausau Center
SUSPENDED

Wausau, Wisconsin, 54401, United States
Marshfield Medical Center - Weston
RECRUITING

Weston, Wisconsin, 54476, United States

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Marshfield Medical Center-EC Cancer Center
RECRUITING

Eau Claire, Wisconsin, 54701, United States

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Marshfield Medical Center-Marshfield
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Marshfield, Wisconsin, 54449, United States

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Marshfield Medical Center-Rice Lake
RECRUITING

Rice Lake, Wisconsin, 54868, United States

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Massachusetts General Hospital Cancer Center
SUSPENDED

Boston, Massachusetts, 02114, United States
Medical College of Wisconsin
ACTIVE_NOT_RECRUITING

Milwaukee, Wisconsin, 53226, United States
Medical Oncology and Hematology Associates-Des Moines
RECRUITING

Des Moines, Iowa, 50309, United States
Memorial Sloan Kettering Basking Ridge
RECRUITING

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen
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Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Monmouth
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Middletown, New Jersey, 07748, United States
Mercy Clinic-Rolla-Cancer and Hematology
RECRUITING

Rolla, Missouri, 65401, United States
Mercy Hospital Fort Smith
RECRUITING

Fort Smith, Arkansas, 72903, United States
Mercy Hospital Joplin
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Joplin, Missouri, 64804, United States
Mercy Hospital Oklahoma City
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Oklahoma City, Oklahoma, 73120, United States
Mercy Hospital Saint Louis
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St Louis, Missouri, 63141, United States
Mercy Hospital South
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St Louis, Missouri, 63128, United States
Mercy Hospital Springfield
RECRUITING

Springfield, Missouri, 65804, United States
Methodist West Hospital
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West Des Moines, Iowa, 50266-7700, United States
Moffitt Cancer Center
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Tampa, Florida, 33612, United States

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Moffitt Cancer Center - McKinley Campus
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Tampa, Florida, 33612, United States

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Moffitt Cancer Center-International Plaza
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Tampa, Florida, 33607, United States

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Montefiore Medical Center - Moses Campus
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The Bronx, New York, 10467, United States
Montefiore Medical Center-Einstein Campus
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The Bronx, New York, 10461, United States
Montefiore Medical Center-Weiler Hospital
RECRUITING

The Bronx, New York, 10461, United States
Mount Sinai Hospital
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New York, New York, 10029, United States
NorthShore University HealthSystem-Evanston Hospital
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Evanston, Illinois, 60201, United States
NorthShore University HealthSystem-Glenbrook Hospital
RECRUITING

Glenview, Illinois, 60026, United States
NorthShore University HealthSystem-Highland Park Hospital
RECRUITING

Highland Park, Illinois, 60035, United States
Northwell Health Imbert Cancer Center
RECRUITING

Bay Shore, New York, 11706, United States
Northwell Health/Center for Advanced Medicine
RECRUITING

Lake Success, New York, 11042, United States
Northwestern University
ACTIVE_NOT_RECRUITING

Chicago, Illinois, 60611, United States
Olathe Health Cancer Center
ACTIVE_NOT_RECRUITING

Olathe, Kansas, 66061, United States
Parkland Memorial Hospital
ACTIVE_NOT_RECRUITING

Dallas, Texas, 75235, United States
Roswell Park Cancer Institute
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Buffalo, New York, 14263, United States
Rush - Copley Medical Center
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Aurora, Illinois, 60504, United States

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Rush University Medical Center
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Chicago, Illinois, 60612, United States

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Saint Alphonsus Cancer Care Center-Boise
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Boise, Idaho, 83706, United States
Saint Alphonsus Cancer Care Center-Caldwell
RECRUITING

Caldwell, Idaho, 83605, United States
Saint Alphonsus Medical Center-Nampa
RECRUITING

Nampa, Idaho, 83686, United States

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Saint Anthony Regional Hospital
RECRUITING

Carroll, Iowa, 51401, United States
Saint Louis Cancer and Breast Institute-Ballwin
RECRUITING

Ballwin, Missouri, 63011, United States
Salina Regional Health Center
ACTIVE_NOT_RECRUITING

Salina, Kansas, 67401, United States
Sanford Bismarck Medical Center
RECRUITING

Bismarck, North Dakota, 58501, United States

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Sanford Broadway Medical Center
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Fargo, North Dakota, 58122, United States

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Sanford Cancer Center Oncology Clinic
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Sioux Falls, South Dakota, 57104, United States

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Sanford Joe Lueken Cancer Center
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Bemidji, Minnesota, 56601, United States

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Sanford Roger Maris Cancer Center
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Fargo, North Dakota, 58122, United States

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Sanford USD Medical Center - Sioux Falls
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Sioux Falls, South Dakota, 57117-5134, United States

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Siteman Cancer Center at Christian Hospital
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St Louis, Missouri, 63136, United States

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Siteman Cancer Center at Saint Peters Hospital
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City of Saint Peters, Missouri, 63376, United States

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Siteman Cancer Center at West County Hospital
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Creve Coeur, Missouri, 63141, United States

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Siteman Cancer Center-South County
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St Louis, Missouri, 63129, United States

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Smilow Cancer Center/Yale-New Haven Hospital
RECRUITING

New Haven, Connecticut, 06510, United States

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Stanford Cancer Institute Palo Alto
RECRUITING

Palo Alto, California, 94304, United States
The Carle Foundation Hospital
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Urbana, Illinois, 61801, United States

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The James Graham Brown Cancer Center at University of Louisville
RECRUITING

Louisville, Kentucky, 40202, United States
Thomas Jefferson University Hospital
RECRUITING

Philadelphia, Pennsylvania, 19107, United States

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UC San Diego Moores Cancer Center
WITHDRAWN

La Jolla, California, 92093, United States
UM Sylvester Comprehensive Cancer Center at Coral Gables
SUSPENDED

Coral Gables, Florida, 33146, United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
RECRUITING

Deerfield Beach, Florida, 33442, United States
UM Sylvester Comprehensive Cancer Center at Plantation
RECRUITING

Plantation, Florida, 33324, United States
UNC Lineberger Comprehensive Cancer Center
RECRUITING

Chapel Hill, North Carolina, 27599, United States

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UPMC Cancer Centers - Arnold Palmer Pavilion
RECRUITING

Greensburg, Pennsylvania, 15601, United States
UPMC Jameson
SUSPENDED

New Castle, Pennsylvania, 16105, United States
UPMC Pinnacle Cancer Center/Community Osteopathic Campus
RECRUITING

Harrisburg, Pennsylvania, 17109, United States
UPMC Washington Hospital Radiation Oncology
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Washington, Pennsylvania, 15301, United States

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UPMC-Heritage Valley Health System Beaver
RECRUITING

Beaver, Pennsylvania, 15009, United States
UPMC-Passavant Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15237, United States
UPMC-Presbyterian Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
UPMC-Shadyside Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
UT Southwestern Clinical Center at Richardson/Plano
ACTIVE_NOT_RECRUITING

Richardson, Texas, 75080, United States
UT Southwestern/Simmons Cancer Center-Dallas
ACTIVE_NOT_RECRUITING

Dallas, Texas, 75390, United States
University of Arizona Cancer Center-North Campus
RECRUITING

Tucson, Arizona, 85719, United States
University of Arizona Cancer Center-Orange Grove Campus
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Tucson, Arizona, 85704, United States
University of Cincinnati Cancer Center-UC Medical Center
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Cincinnati, Ohio, 45219, United States

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University of Cincinnati Cancer Center-West Chester
RECRUITING

West Chester, Ohio, 45069, United States

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University of Kansas Cancer Center
ACTIVE_NOT_RECRUITING

Kansas City, Kansas, 66160, United States
University of Kansas Cancer Center - North
ACTIVE_NOT_RECRUITING

Kansas City, Missouri, 64154, United States
University of Kansas Cancer Center at North Kansas City Hospital
ACTIVE_NOT_RECRUITING

North Kansas City, Missouri, 64116, United States
University of Kansas Cancer Center-Overland Park
ACTIVE_NOT_RECRUITING

Overland Park, Kansas, 66210, United States
University of Kansas Health System Saint Francis Campus
ACTIVE_NOT_RECRUITING

Topeka, Kansas, 66606, United States
University of Kansas Hospital-Westwood Cancer Center
ACTIVE_NOT_RECRUITING

Westwood, Kansas, 66205, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center
RECRUITING

Miami, Florida, 33136, United States
University of Michigan Comprehensive Cancer Center
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Oklahoma Health Sciences Center
ACTIVE_NOT_RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of Pittsburgh Cancer Institute (UPCI)
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
University of Rochester
RECRUITING

Rochester, New York, 14642, United States
VA Palo Alto Health Care System
RECRUITING

Palo Alto, California, 94304, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

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Wayne State University/Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201, United States

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Weisberg Cancer Treatment Center
RECRUITING

Farmington Hills, Michigan, 48334, United States

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Welch Cancer Center
RECRUITING

Sheridan, Wyoming, 82801, United States

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Yale University
RECRUITING

New Haven, Connecticut, 06520, United States

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