Ecog-acrin Cancer Research Group

This study tests whether adding daratumumab to standard lenalidomide and dexamethasone can delay or prevent smoldering myeloma from becoming active multiple myeloma. About 288 people with high-risk smoldering myeloma will participate. The goal is to see if the combination improve…

This study is for people with stomach cancer that has spread to the lining of the abdomen. It compares standard chemotherapy given through a vein to the same treatment plus an extra chemotherapy drug (paclitaxel) delivered directly into the belly through a small port. The goal is…

This study tests whether adding a chemotherapy pump that delivers drugs directly to the liver (hepatic arterial infusion) to standard chemotherapy helps people with colorectal cancer that has spread to the liver and cannot be removed by surgery. About 408 adults with cancer only …

This study compares radiation therapy alone versus radiation plus the chemotherapy drug cisplatin in people with stage III-IVA head and neck cancer who have already had surgery to remove their tumor. About 189 participants will be randomly assigned to one of the two treatments. T…

This study is for people with advanced sinus cancer that requires removal of parts of the eye socket or skull base. It tests whether adding chemotherapy before standard surgery and radiation can shrink the tumor enough to save these structures. About 82 participants will be rando…

This study tests whether adding a fourth drug (bortezomib) to a standard three-drug regimen (daratumumab, lenalidomide, dexamethasone) can better control multiple myeloma in people who are not eligible for early stem cell transplant. About 1,450 participants will be randomly assi…

This study is for adults with a type of thyroid cancer that has stopped responding to standard radioactive iodine treatment and has a specific genetic change (BRAF V600E). It compares two treatment options: a single drug called cabozantinib versus a combination of two drugs, dabr…

This study is for men whose prostate cancer has come back (shown by rising PSA levels) after their prostate was removed. It tests whether using PET scans to guide more personalized treatment—adding the drug apalutamide with or without targeted radiation—works better than standard…

This study tests whether a connected platform (a special medication bag called WiseBag plus text reminders) helps people with metastatic breast cancer take their CDK4/6 inhibitor pills more consistently. About 410 patients will either use the bag alone or the bag with text alerts…

This study tests a program called CostCOM that provides financial counseling and resources to cancer patients. The goal is to see if it helps them stick with their treatments and reduces the financial burden of medical costs. About 760 patients will take part.

This study looks at whether advanced imaging methods can give more accurate information about tumor activity in people with a newly diagnosed type of brain cancer called glioblastoma. Standard MRI scans can be confusing because changes after treatment may look like tumor growth b…

This study looks at how social, psychological, and genetic factors influence the long-term health of young adults (ages 15-39) who survived Hodgkin or non-Hodgkin lymphoma. Researchers will collect blood samples and health information from 2000 survivors to understand why some fa…

This study compares two ways of monitoring pancreatic cysts: more frequent check-ups versus less frequent ones. The goal is to see which approach leads to better outcomes for patients. About 4,600 people aged 50 to 75 with pancreatic cysts will take part. The study does not test …