Ecog-acrin Cancer Research Group

This large study tested whether a short, intense 4-week course of a drug called interferon alfa-2b could help prevent melanoma skin cancer from coming back after it had been surgically removed. It compared the drug treatment to simply watching patients closely (observation) in ov…

This study is testing whether a concentrated green tea extract can help prevent low-risk prostate cancer from getting worse. It involves 360 men who are on active surveillance, meaning they are monitoring their cancer instead of treating it right away. Participants will take eith…

This study compares three different drug combinations for people 70 or younger with newly diagnosed mantle cell lymphoma, a type of blood cancer. Researchers want to see if adding a newer targeted drug called acalabrutinib to standard chemotherapy works better than chemotherapy a…

This study is testing a new approach for patients with a specific type of breast cancer (HER2-positive, stage II-IIIa). The goal is to see if patients who have no detectable cancer left after initial pre-surgery treatment can safely skip additional, stronger chemotherapy after th…

This study is for people with advanced stomach or esophageal cancer that has spread to only a few other places in the body. It tests if adding a short course of targeted radiation to standard chemotherapy works better than chemotherapy alone to control the cancer and help patient…

This study is testing if adding an immunotherapy drug called pembrolizumab to standard CML medications can help patients achieve a deeper remission. It is for patients whose cancer is controlled but still detectable at very low levels. The goal is to see if this combination can e…

This study is for patients with a specific, aggressive type of breast cancer (triple-negative, basal-like) where cancer cells remain after initial chemotherapy and surgery. It aims to find out which of two follow-up chemotherapy drugs—platinum-based drugs (cisplatin/carboplatin) …

This study is testing a combination of two drugs, venetoclax and vincristine, for adults with a fast-growing blood cancer called acute lymphoblastic leukemia (ALL) that has come back or hasn't responded to previous treatments. The goal is to see if using these drugs together is s…

This study aims to find the best way to monitor pancreatic cysts, which can sometimes develop into cancer. It compares two different schedules of scans and tests: one with more frequent monitoring and one with less. The goal is to see which approach leads to better health outcome…

This study is for men with high-risk prostate cancer who have had surgery to remove the prostate. It tests whether adding a new drug called darolutamide to standard hormone-blocking therapy is better at preventing the cancer from spreading to other parts of the body. The goal is …

This large, late-stage trial is for adults with a type of blood cancer called mantle cell lymphoma who are in remission after initial treatment. It aims to find out if adding an intensive stem cell transplant to a standard drug (rituximab) is better at keeping the cancer from com…

This study is testing if a drug called crizotinib can help prevent early-stage lung cancer from coming back after surgery. It is for patients whose cancer has a specific genetic change called ALK-positive. After surgery, participants are randomly assigned to either take the drug …

This large, late-stage trial aims to find the best initial treatment and long-term management strategy for people newly diagnosed with a specific type of blood cancer called multiple myeloma. It compares two different three-drug combinations to see which one better controls the c…

This study is testing whether keeping blood pressure very low (under 120) is better than the usual target (under 140) for patients with advanced kidney or thyroid cancer who are starting specific cancer drugs. The goal is to see if this intensive approach is doable, safe, and hel…

This study is testing if a lower dose of chemotherapy combined with radiation works as well as the standard, stronger dose for treating early-stage anal cancer. It aims to see if the lower dose can still control the cancer while causing fewer side effects, like bowel and sexual p…

This study is testing whether a newer chemotherapy combination (temozolomide and capecitabine) works better than the current standard treatment (cisplatin/carboplatin and etoposide) for patients with an advanced, fast-growing type of neuroendocrine cancer in the stomach, intestin…

This study is for men whose prostate cancer has spread and stopped responding to standard hormone therapy and an initial round of chemotherapy. It tests if adding a second chemotherapy drug (cabazitaxel) to a standard hormone-blocking drug (abiraterone) is more effective at contr…

This study is testing two chemotherapy approaches for people with advanced pancreatic neuroendocrine tumors that have progressed. Researchers want to see if adding the drug capecitabine to temozolomide works better than temozolomide alone at controlling tumor growth. The trial in…

This study aims to find out which of two standard chemotherapy combinations helps older adults with advanced pancreatic cancer that has spread live longer. It will enroll 176 patients aged 70 and older who have not yet received treatment for their metastatic cancer. Researchers w…

This study is testing if doctors can safely stop a standard immunotherapy treatment early for people with advanced melanoma. It uses special PET scans and sometimes a biopsy taken after one year of treatment to check if the cancer is under control. If the scan and biopsy show no …

This study is for adults whose head and neck cancer has spread to a few other places in the body. It tests if adding a targeted course of radiation therapy to standard immunotherapy helps patients live longer than immunotherapy alone. About 290 participants will be randomly assig…

This large, late-stage trial is testing if adding a precise, high-dose radiation treatment to the standard drug therapy helps people with kidney cancer that has spread to a limited number of other body sites. It will compare survival, side effects, and quality of life between pat…

This study tests whether using simplified treatment guidelines along with expert support can reduce early deaths in patients with acute promyelocytic leukemia (APL), a fast-moving blood cancer. The goal is to cut the one-month death rate from 30% to under 15% by helping doctors a…

This study is testing whether giving chemotherapy both before and after surgery works better than giving it only after surgery for people with stage II or III gallbladder cancer. About 186 patients will be randomly assigned to receive the standard treatment (surgery followed by c…

This large study is testing if a combination of two chemotherapy drugs (gemcitabine and docetaxel) works as well as the standard BCG treatment for a specific type of bladder cancer. It involves about 870 adults with high-grade, non-muscle invasive bladder cancer who have not had …

This study is testing whether using an MRI scan and a genetic test together can help doctors make better decisions for people with a very early form of breast cancer called DCIS. Researchers want to see if these tools can more accurately show the extent of the disease and predict…

This study is testing whether a special type of PET/CT scan can better measure how well treatment is working for breast cancer that has spread to the bones. About 138 patients with this type of advanced cancer will get the scan before starting treatment and again 12 weeks later. …

This study is testing whether a special type of MRI scan can help doctors more accurately determine how aggressive a man's prostate cancer is before he has surgery. The goal is to see if these detailed images, combined with other test results, can create a better prediction model…

This study is testing a special imaging scan (FDG-PET/CT) to see if it can predict how well standard chemotherapy works for patients with HER2-positive breast cancer before they have surgery. The scan is done early in treatment to measure changes in the cancer's activity. If succ…

This study compares two breast cancer screening methods for women with dense breast tissue: a quick 10-minute MRI scan and a 3D mammogram. Researchers want to see which method finds more invasive cancers while causing fewer unnecessary callbacks and biopsies. Over 1,500 women par…

This large study aims to find out if a newer type of 3D mammogram (tomosynthesis) is better than the standard 2D digital mammogram for routine breast cancer screening. Over 100,000 women are being randomly assigned to receive one of the two screening methods over several years. T…

This study is testing whether a special type of MRI scan can predict how well patients with recurrent glioblastoma (a type of brain cancer) will respond to the drug bevacizumab. Researchers are measuring changes in blood flow within the tumor two weeks after starting treatment to…

This study aims to understand how cancer treatment affects patients' finances and employment. Researchers are following 565 people with early-stage colon or rectal cancer for two years, asking them to complete surveys about costs, work life, and quality of life. The goal is to me…

This study aims to validate a genetic test that might predict which African American women with early-stage breast cancer are at higher risk for nerve damage (neuropathy) from common chemotherapy drugs. It also compares two different chemotherapy schedules to see which one might …

This study aimed to understand how community cancer clinics test for biomarkers—specific genetic changes in tumors—to help guide treatment decisions for common cancers like breast, lung, and colorectal. It planned to survey pathology labs to see what tests they run, how quickly t…