Ecog-acrin Cancer Research Group

This study tested a simplified care plan for people with acute promyelocytic leukemia (APL), a rare blood cancer. The goal was to reduce deaths soon after starting treatment. About 200 patients followed easy-to-use guidelines with support from APL experts. The main focus was on h…

This study tests whether adding pembrolizumab (an immunotherapy) to standard tyrosine kinase inhibitors (TKIs) can eliminate leftover leukemia cells in people with chronic myeloid leukemia (CML). About 40 adults with stable disease but detectable cancer markers will receive the c…

This study tests whether adding a stem cell transplant to maintenance therapy with rituximab helps people with mantle cell lymphoma stay in remission longer compared to rituximab alone. About 689 adults aged 18-70 whose cancer is in first complete remission with no detectable dis…

This study tests whether green tea catechins (natural compounds found in green tea) can prevent low-risk prostate cancer from getting worse in men who are closely monitoring their condition instead of undergoing immediate treatment. About 360 men will take either green tea catech…

This study tests whether platinum-based chemotherapy (cisplatin or carboplatin) is better than capecitabine at preventing breast cancer from coming back in people with a specific type of triple-negative breast cancer (basal-like) that was not completely removed by initial chemoth…

This study tests whether adding darolutamide to standard hormone therapy (ADT) after prostate removal surgery can delay or prevent cancer from spreading in men at highest risk. About 27 participants will receive either darolutamide or a placebo alongside ADT. The goal is to see i…

This phase 3 trial compares two drug combinations (VRd and CRd) as initial treatment for people newly diagnosed with multiple myeloma, a blood cancer. Over 1,000 participants receive one of the combos, followed by maintenance therapy to keep the cancer in check. The goal is to se…

This study looks at whether a lower dose of chemotherapy plus radiation can control early-stage anal cancer as well as the standard higher dose, while causing fewer side effects. About 252 adults with small tumors (4 cm or less) that haven't spread will take part. The goal is to …

This study tests whether a combination of two chemotherapy drugs (Gemcitabine and Docetaxel) given directly into the bladder works as well as the standard BCG therapy for patients with high-grade non-muscle invasive bladder cancer who have not received BCG before. About 870 adult…

This study tests whether taking crizotinib after surgery can prevent early-stage non-small cell lung cancer from coming back in people whose tumors have a specific ALK gene change. About 166 participants who had their cancer completely removed will either take crizotinib or just …

This study tests whether adding radiation therapy to standard chemotherapy helps people with HER2 negative esophageal or stomach cancer that has spread to only a few spots in the body. About 314 participants will receive either chemotherapy alone or chemotherapy plus radiation. T…

This study looks at whether keeping blood pressure very low (below 120 mmHg) is better than the usual target (below 140 mmHg) for people with advanced kidney or thyroid cancer starting certain targeted therapies. The goal is to reduce the risk of heart and kidney problems caused …

This study looks at whether doctors can safely stop standard anti-PD-1 immunotherapy early in people with advanced melanoma that cannot be surgically removed. Using PET/CT scans and tumor biopsies as guides, the goal is to see if stopping treatment sooner still keeps the cancer u…

This study compares two treatments for head and neck cancer that has spread to other parts of the body. All participants receive the immunotherapy drug pembrolizumab plus chemotherapy. Half also get targeted radiation to their tumors. The goal is to see if adding radiation helps …

This study tests whether giving precise, high-dose radiation to a limited number of cancer spots (2-5) before starting standard drug therapy can help people with metastatic kidney cancer live longer. About 472 adults with kidney cancer that has spread are taking part. The goal is…

This study tests two different chemotherapy combinations in older adults (age 70+) whose pancreatic cancer has spread. The goal is to see which treatment helps people live longer. Both treatments are already used for pancreatic cancer, but this trial focuses specifically on older…

This study tested whether a combination of temozolomide and capecitabine works better than the standard cisplatin and etoposide for people with advanced neuroendocrine cancer of the gut or pancreas that cannot be removed by surgery. The trial enrolled 67 participants and was stop…

This study tested two chemotherapy drugs—temozolomide alone or combined with capecitabine—in 144 people with advanced pancreatic neuroendocrine tumors that could not be removed by surgery. The goal was to see if the combination could delay tumor growth better than the single drug…

This study tests three different chemotherapy combinations in adults aged 70 or younger with newly diagnosed mantle cell lymphoma, a rare and aggressive blood cancer. The goal is to see which combination works best to shrink tumors and clear cancer cells from the blood. Participa…

This study looks at whether women with HER2-positive breast cancer who have no cancer left after initial treatment can safely receive fewer chemotherapy drugs after surgery. About 2,175 participants will get a combination of paclitaxel, trastuzumab, and pertuzumab before surgery,…

This study tests whether adding the chemotherapy drug cabazitaxel to the hormone therapy abiraterone works better than abiraterone alone for men with advanced prostate cancer that has spread and is no longer responding to standard hormone therapy. About 223 men who have already r…

This study looks at people with HPV-positive throat cancer that has spread but can still be removed with surgery. After surgery, some patients get the usual high-dose radiation plus chemo, while others get a lower dose. The goal is to see if the lower dose works just as well to k…

This study looks at whether giving chemotherapy both before and after surgery helps people with stage II-III gallbladder cancer live longer than the usual approach of surgery followed by chemo. About 186 participants will be randomly assigned to one of two groups. The goal is to …

This study looked at whether giving a high dose of the drug interferon alfa-2b for four weeks can help prevent melanoma from returning after it has been completely removed by surgery. About 1,150 people with stage II or III melanoma took part. Half received the drug, and half wer…

This study tests a new combination of two drugs—venetoclax and vincristine—in adults with acute lymphoblastic leukemia (ALL) that has returned or not responded to prior therapy. The goal is to find the safest dose and see if the combination can help more patients achieve remissio…

This study compares two screening methods—abbreviated breast MRI and digital tomosynthesis mammography—to see which detects cancer better in women with dense breasts. About 1,500 asymptomatic women participated. The goal is to find a more effective screening approach for this gro…

This study looks at whether a type of PET/CT scan (FDG-PET/CT) can better measure how breast cancer that has spread to the bones responds to treatment. About 138 adults with hormone receptor-positive, HER2-known breast cancer that is mostly in the bones will get the scan before a…

This study tests whether a special PET/CT scan (FDG-PET/CT) can predict how well HER2-positive breast cancer responds to chemotherapy before surgery. About 235 adults with stage II-III breast cancer will get a scan early in treatment to see if it accurately identifies who will ha…

This study looks at whether a special type of MRI, called multiparametric MRI, can more accurately determine the stage of prostate cancer in people recently diagnosed. The goal is to help doctors better identify aggressive cancers and plan the right surgery. About 850 participant…

This large study compares two mammogram methods—standard digital mammography and a newer 3D technique called tomosynthesis—to see which is better at catching breast cancer early. Over 108,000 women without breast symptoms are taking part. The goal is to find out if tomosynthesis …

This study follows 565 people with stage I-III colon or rectal cancer who are being treated with the goal of a cure. Researchers track how treatment affects patients' finances and quality of life over 12 months. The goal is to help doctors understand the financial burden of cance…

This study looks at whether a special type of MRI (DSC-MRI) can measure blood flow changes in brain tumors to quickly tell if a drug called bevacizumab is working. About 146 adults with recurrent glioblastoma will get the MRI before and after starting treatment. The goal is to se…

This study looks at whether certain genes make African American women with breast cancer more likely to develop nerve damage from chemotherapy drugs like docetaxel or paclitaxel. About 249 women with stage I-III breast cancer took part. The goal is to find out if a genetic test c…

This study was designed to look at how community cancer clinics test for biomarkers in common cancers like lung, breast, and colorectal cancer. The goal was to find out if testing is fast and accurate, and to spot any differences in how tests are done. However, the study was with…

This study looks at whether combining MRI scans with genetic testing can help doctors choose the best treatment for people with ductal carcinoma in situ (DCIS), a very early form of breast cancer that hasn't spread. About 368 participants will have MRI and genetic analysis to see…