Could a shot every 6 months replace daily HIV pills?
NCT ID NCT05729568
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a combination of two lab-made antibodies and an antiviral drug called lenacapavir, given every 6 months, can keep HIV under control in adults whose virus is already suppressed by daily pills. About 83 participants will either switch to the new long-acting regimen or stay on their current oral therapy. The main goal is to see if the new treatment is as effective at keeping HIV levels low after 26 weeks.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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AIDS Arms, Inc. DBA Prism Health North Texas
Dallas, Texas, 75208, United States
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AXCES Research Group, LLC
Albuquerque, New Mexico, 87109, United States
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AXCES Research Group, LLC
El Paso, Texas, 79902, United States
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Alfred Hospital
Melbourne, Victoria, 3004, Australia
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Can Community Health Care
Fort Lauderdale, Florida, 33316, United States
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Central Texas Clinical Research
Austin, Texas, 78705, United States
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Clinical Alliance for Research & Education, Infectious Diseases LLC (CARE-ID)
Annandale, Virginia, 22003, United States
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Clinical Research Puerto Rico
San Juan, 909, Puerto Rico
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Duke University Health Center
Durham, North Carolina, 27710, United States
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East Sydney Doctors
Darlinghurst, New South Wales, 2010, Australia
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Emory University Hospital Midtown Infectious Disease Clinic
Atlanta, Georgia, 30308, United States
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Georgetown University Medical Center
Washington D.C., District of Columbia, 20007, United States
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Holdsworth House Medical Practice
Sydney, New South Wales, 2010 NSW, Australia
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Infectious Disease Specialists of Atlanta
Decatur, Georgia, 30033, United States
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Maple Leaf Research/Maple Leaf Medical Clinic
Toronto, M5G 1K2, Canada
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Midland Florida Clinical Research Center, LLC
DeLand, Florida, 32720, United States
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Midway Immunology and Research Center
Ft. Pierce, Florida, 34982, United States
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Mills Clinical Research
Los Angeles, California, 90069, United States
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Montefiore Medical Center
The Bronx, New York, 10467, United States
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NC TraCS Institute - CTRC; University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, 27514, United States
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Optimus Medical Group
San Francisco, California, 94102, United States
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Orlando Immunology Center
Orlando, Florida, 32803, United States
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Prisma Health - Clinical Research Unit
Columbia, South Carolina, 29203, United States
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Regional Center for Infectious Disease Research
Greensboro, North Carolina, 27401, United States
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Rosedale Health and Wellness
Huntersville, North Carolina, 28078, United States
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Ruane Clinical Research Group, Inc.
Los Angeles, California, 90036, United States
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Southhampton Healthcare, Inc
St Louis, Missouri, 63139, United States
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St Jude Children's Research Hospital
Memphis, Tennessee, 38105, United States
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The Brody School of Medicine at East Carolina University
Greenville, North Carolina, 27858, United States
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The Crofoot Research Center, INC
Houston, Texas, 77098, United States
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Triple O Research Institute, P.A.
West Palm Beach, Florida, 33407, United States
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UC San Diego (UCSD) AntiViral Research Center (AVRC)
San Diego, California, 92103, United States
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University of Colorado Clinical and Translational Research Center
Aurora, Colorado, 80045, United States
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Yale University; School of Medicine; AIDS Program
New Haven, Connecticut, 06510, United States