Disease of primarily extrinsic mechanism

This Phase 3 study tested two Sanofi COVID-19 vaccines (one targeting the original virus, another targeting two variants) in about 24,000 adults. The goal was to see if they could prevent COVID-19 safely. The trial was terminated early, so final results are limited, but the data …

This study tested several experimental mRNA vaccines against shingles in healthy adults aged 50 to 85. The goal was to check safety and immune response compared to the current shingles vaccine, Shingrix. The trial was terminated early, so results are limited, but the data may hel…

This early-stage trial tested an experimental HIV vaccine in 44 healthy adults to see if it was safe and triggered an immune response. The vaccine uses a piece of the HIV virus (fusion peptide) to train the body's defenses. The study was terminated early, so the full results are …

This early-stage trial tested a nasal spray vaccine against Ebola in 15 healthy adults. The vaccine uses a weakened common cold virus to deliver a piece of the Ebola virus. The study aimed to check safety and immune response, but it was terminated early, so results are limited.

This study tested an experimental RSV vaccine given to healthy infants at 6 and 12 months old alongside their regular vaccines. The goal was to see if the RSV vaccine still worked well when given at the same time. About 2,200 babies took part, but the study was stopped early.

This study tested a nasal spray RSV vaccine in nearly 1,000 healthy infants and toddlers aged 6 to 22 months. The goal was to see if a lower dose works as well as the standard dose and to check safety across different doses. The trial was ended early, so final results are not ava…

This phase 3 study tested an intranasal RSV vaccine in about 6,300 healthy children aged 6 to 22 months. The goal was to see if two doses of the nasal spray could prevent lower respiratory tract infections caused by RSV. The trial was terminated early, so final results are not av…

This early-stage trial tested a new vaccine against Plasmodium vivax malaria, given with an adjuvant to boost immune response. It involved 25 healthy adults in the UK to check safety and immune reactions. The study was terminated early, so full results are not available.

This early-stage trial tested the safety and immune response of two experimental Ebola vaccines in 38 healthy UK adults. Some volunteers received one vaccine, while others got a prime-boost combination. The vaccines use harmless viruses to train the immune system against Ebola wi…

This phase 3 trial tested an mRNA vaccine (mRNA-1647) to prevent cytomegalovirus (CMV) infection in healthy people aged 16 to 40. The study enrolled over 7,400 participants, focusing on women who had never been infected with CMV. The vaccine aims to trigger an immune response to …

This study looked at whether the mRNA-1273.214 COVID-19 vaccine is safe and works in infants as young as 12 weeks to under 6 months old. It was a small, early-stage trial that was stopped before completion. The main goal was to check for side effects like fever, fussiness, and in…

This early-stage study tested a new meningococcal B vaccine in 576 healthy people, from infants to adults. Researchers checked for side effects and measured immune responses, comparing the new vaccine to two already-approved ones. The goal was to see if the vaccine is safe and tr…

This study tested Sanofi's experimental mRNA vaccine against COVID-19 in 182 healthy adults aged 18 and older. The main goals were to check safety and measure the body's immune response. The trial was terminated early, so full results are not available.

This phase 2 study tests whether combining magrolimab and pembrolizumab can shrink or eliminate tumors in people with classic Hodgkin lymphoma that has come back or not responded to at least two prior treatments. Magrolimab targets a 'don't eat me' signal on cancer cells, while p…

This study tests an experimental treatment called GLPG5101 for people with B-cell non-Hodgkin lymphoma that has come back or not responded to standard therapy. The treatment is a cell therapy made at the hospital. The study has two phases: first, finding the best dose with the fe…

This phase 2 study tests whether an oral antiviral pill called obeldesivir can safely shorten RSV symptoms in adults who are not hospitalized but are at higher risk for severe disease (e.g., those aged 60+ or with chronic lung conditions). Participants take the pill or a placebo,…

This phase 2 trial tests whether a combination of atovaquone (an anti-malarial) and azithromycin (an antibiotic) can clear the COVID-19 virus in infected adults. The study enrolls people at high risk for complications, such as those with moderate to severe illness. Participants r…

This study tests whether adding peer-based counseling to standard HIV and opioid treatment helps people who inject drugs stay on their medications and achieve viral suppression. Participants receive either enhanced usual care or extra support from a peer counselor. The goal is to…

This early-phase trial tested a new therapy called CYNK-001, which uses natural killer cells from the placenta to fight COVID-19. It enrolled only 7 adults with moderate COVID-19. The study was terminated early, so we have limited information on safety and effectiveness.

This early-phase trial tested a combination of two immune-boosting drugs, relatlimab and nivolumab, in children and young adults with Hodgkin or non-Hodgkin lymphoma that had come back or not responded to treatment. The goal was to check safety, drug levels, and whether the tumor…

This study provides continued access to itacitinib for 18 patients who were already benefiting from the drug in earlier trials. Participants have myelofibrosis, chronic graft-versus-host disease, or bronchiolitis obliterans after lung transplant. They continue their same dose as …

This study tested a drug called deupirfenidone (LYT-100) in 185 adults who had breathing problems after a serious COVID-19 infection. Participants took either the drug or a placebo for several weeks to see if it improved their ability to walk. The trial was stopped early, so the …

This phase 3 trial tested whether adding bevacizumab (Avastin) to standard chemotherapy (docetaxel and gemcitabine) helps people with advanced or recurrent uterine leiomyosarcoma. The study enrolled 107 participants but was terminated early. Researchers measured how long patients…

This study tested whether the drug tecovirimat could safely treat mpox and speed up recovery. About 719 people with mpox took either tecovirimat or a placebo. The main goals were to see if the drug reduced the time for skin lesions to heal and lessened pain. The study was termina…

This phase 3 trial tested whether adding ADI-PEG 20 to standard chemotherapy (gemcitabine and docetaxel) could help people with advanced leiomyosarcoma, a rare soft tissue cancer. The study planned to enroll 218 participants whose cancer had progressed after prior treatment. Unfo…

This study tests an oral drug called AK0529 (Ziresovir) in adults aged 18 to 75 with respiratory syncytial virus (RSV) infection. Participants receive either the drug or a placebo, and researchers measure how well symptoms improve and track any side effects. The goal is to see if…

This study tested whether an extra dose of bezlotoxumab, a drug that blocks the harmful toxin made by C. diff bacteria, could help very sick patients recover after emergency colon surgery. Only 5 people took part before the study was stopped early. The goal was to see if the drug…

This study aimed to see if liver transplantation is possible and safe for people infected with both HIV and hepatitis C. Fifteen patients were enrolled to track survival, virus behavior, and drug interactions after transplant. The goal was to understand how these two viruses inte…

This study tests a drug called loncastuximab tesirine in adults with B-cell lymphomas that have returned or not responded to prior treatment. The drug works like a smart bomb, attaching to a marker on cancer cells and delivering chemotherapy directly to them. The main goal is to …

This early-stage study tested a new experimental drug called GSK3965193, alone and in combination with another drug (bepirovirsen), for people with chronic hepatitis B. The goal was to see if the combination could lower hepatitis B virus levels and possibly lead to a sustained re…

This study tested an oral drug called epetraborole for people with a tough-to-treat lung infection called MAC lung disease. The trial aimed to see if adding epetraborole to standard treatment could improve symptoms and clear the infection. However, the study was terminated early,…

This study tests whether an additional dose of a COVID-19 vaccine can improve immune protection in adults and children with autoimmune diseases like rheumatoid arthritis, lupus, multiple sclerosis, and others who are taking immunosuppressive medications. Participants who had a we…

This study tested an experimental drug called APX-115 in hospitalized patients with mild to moderate COVID-19. The goal was to see if it was safe and could help people recover faster. However, the trial was stopped early and only 16 people took part, so we don't have enough infor…

This study tested whether injecting vidutolimod directly into tumors plus giving cemiplimab through a vein could shrink cancers that have spread. The trial included 77 people with several types of advanced cancer. Unfortunately, the study was stopped early, so we have less inform…

This study tested whether a low dose of tocilizumab, a drug used for arthritis, could help hospitalized COVID-19 patients with lung inflammation who were not on a breathing machine. The goal was to see if it sped up recovery and reduced deaths. The trial was stopped early, but re…

This early-phase trial tested a new oral drug called BBI-355, alone or with other targeted therapies, in people with advanced solid tumors that had extra DNA (oncogene amplifications). The study aimed to find the safest dose and check for side effects. It was terminated early, so…

This study compared two HIV treatment approaches in people who had never taken HIV drugs before. One group started with a three-drug combo for 16 weeks, then switched to a two-drug combo. The other group took a two-drug combo from the start. The goal was to see if the first appro…

This early-stage study tested a new drug called PF-07265807 in people with advanced or metastatic solid tumors that had spread. The main goals were to find a safe dose and check for side effects. The trial was terminated early, so results are limited.

This phase II trial tested the drug everolimus in 11 people with classic or endemic Kaposi's sarcoma, a rare skin cancer linked to a virus. The goal was to see if the drug could shrink tumors after 6 months. The study was terminated early, so the full results are not available.

This study tested whether giving the heart medication metoprolol through a vein could help people with severe lung failure (ARDS) in the ICU. The goal was to see if it helped them breathe without a machine for more days. However, the trial was stopped early and only 14 people too…

This study tested whether adding aspirin or ibuprofen to standard tuberculosis (TB) treatment helps patients recover more quickly. It included 426 adults with drug-sensitive or drug-resistant TB. The trial was terminated early, so the results are not conclusive.

This study tested a new drug, TQ05105, in 13 people who had severe graft-versus-host disease (aGVHD) after a stem cell transplant and did not respond to steroids. The goal was to see if the drug is safe and can help control the disease. The study was stopped early, so results are…

This study looked at whether switching from a standard HIV drug combination to a different one (Delstrigo) could improve cholesterol, body fat, and blood sugar in people with HIV. The study planned to enroll 60 adults whose HIV was already well-controlled. Participants were rando…

This study tested giving hepatitis C treatment to people who inject drugs while they were already in the hospital for other infections. The goal was to cure their hepatitis C and make sure they stayed connected to care afterward. The study was stopped early, but it included 21 pa…

This study tested a reduced-intensity bone marrow transplant, or 'mini transplant,' for people with blood cancers like lymphoma and leukemia. The transplant used marrow from a relative and was combined with chemotherapy drugs to help the donor cells take hold. Only 15 people took…

This early-stage trial tested whether specially grown immune cells could help transplant patients fight off stubborn viral infections. The study included 8 people who had received a stem cell or organ transplant and had ongoing infections with adenovirus, CMV, or EBV. The approac…

This early-phase trial tested whether inhaling low doses of carbon monoxide could be safe for people with severe lung injury caused by sepsis. Only 5 participants were enrolled before the study was stopped early. The goal was to see if a personalized dosing formula could safely a…

This phase II trial tested whether the drug ibrutinib could prevent chronic graft-versus-host disease (GVHD) in adults who had received a donor stem cell transplant. Only 2 people enrolled before the study was terminated early. Because of the very small number of participants, no…

This clinical trial tested whether combining several drugs—bedaquiline, OPC-167832, sutezolid, and either pretomanid or delamanid—could treat pulmonary tuberculosis in just 2 to 4 months instead of the standard 6 months. The study enrolled 93 adults with drug-sensitive or drug-re…

This study tested a drug called INB03 in 79 high-risk COVID-19 patients to see if it could prevent their breathing from getting worse. Participants received two weekly injections of either INB03 or a placebo. The trial was terminated early, so we do not have clear results on whet…

This study looked at using umbilical cord blood transplants after strong chemotherapy and radiation to treat various blood cancers like leukemia and lymphoma. It involved 200 participants and aimed to see how many were alive one year after transplant. The trial was stopped early,…

This phase 2 trial tested two different drug combinations to prevent graft-versus-host disease (GVHD) in 150 people with blood cancers receiving a stem cell transplant from an unrelated donor. Both combinations used cyclosporine and sirolimus, plus either mycophenolate mofetil or…

This study looked at adding a targeted drug called venetoclax to low-intensity chemotherapy for adults with acute lymphoblastic leukemia (ALL) that came back or didn't respond to treatment. The goal was to find the safest dose and see if the combination could help control the dis…

This study tested whether giving plasma (the liquid part of blood) from people who recovered from COVID-19 could help hospitalized patients with moderate to severe COVID-19. The plasma contains antibodies that might fight the virus. The trial planned to enroll many patients but w…

This early-phase study tested a new drug called PF-08046032, given alone or with another drug (sasanlimab), in adults with advanced lymphomas or solid tumors like lung cancer and melanoma. The trial aimed to check safety and find the right dose, but it was terminated early after …

This early-stage study tested a new drug, PF-08046044/SGN-35C, in people with advanced lymphomas (Hodgkin and non-Hodgkin types) who had no other treatment options. The main goal was to check safety and find the right dose. The study was terminated early, so results are limited.

This study looked at whether people who had heart surgery for endocarditis (a serious heart infection) related to IV drug use could safely switch from IV antibiotics to oral pills after just two weeks. The goal was to see if this shorter hospital stay was safe and effective. The …

This trial tested a treatment made from placenta cells (called decidua stroma cells) in 12 adults who had severe graft-versus-host disease (GVHD) after a stem cell transplant and did not respond to steroids. Patients received two doses of the cells or the best available standard …

This study looked at the best way to treat a tonsillar abscess, a painful infection near the tonsils. It compared two treatments: removing the tonsils (tonsillectomy) versus draining the pus with a needle under local anesthesia. The goal was to see which method works better to cl…

This early-phase trial tested the drug plinabulin combined with radiation and immunotherapy in 19 people with advanced cancers (like lung, bladder, or melanoma) that had stopped responding to standard immunotherapy. The goal was to see if the combination was safe and could shrink…

This study looked at adding two immunotherapy drugs (ipilimumab and nivolumab) to standard radiation for people with advanced HPV-positive throat cancer. The goal was to see if the combination was safe and could shrink tumors better than radiation alone. The trial enrolled 37 par…

This study tested whether a simple stool test can guide doctors in choosing the right antibiotics for H. pylori infections, avoiding the need for an invasive stomach camera procedure. The test detects the bacteria and checks for antibiotic resistance, aiming to improve cure rates…

This study tested whether adding an inhaled medication (PC945) to standard antifungal drugs could help people with a severe, hard-to-treat lung fungal infection called invasive pulmonary aspergillosis. The trial aimed to see if the combination improved survival and response by da…

This study tested a drug called CardiolRx in 90 hospitalized COVID-19 patients who also had heart disease or risk factors like diabetes or high blood pressure. The goal was to see if the drug could lower the chance of death, needing intensive care, or having heart problems. The t…

This early-stage trial tested an oral drug called AUR105 in 17 adults with advanced solid tumors or lymphomas that had not responded to prior treatments. The study aimed to find a safe dose and check how the drug moves through the body. However, the trial was terminated, so resul…

This early-stage study tested an oral drug called AUR104 in 9 adults with certain blood cancers (lymphomas and leukemia) that had come back or stopped responding to treatment. The main goal was to check the drug's safety and how the body processes it. The trial was terminated ear…

This study tested whether a once-weekly oral combination of two experimental drugs (lepetegravir and lenacapavir pacfosacil) could control HIV as well as the standard daily pill Biktarvy. It enrolled 73 people newly diagnosed with HIV-1 who had never taken HIV medication. The stu…

This study looked at whether starting continuous skin-to-skin contact (kangaroo mother care) within 24 hours of birth helps unstable preterm babies under 2000g survive. It compared this to standard incubator care. The trial took place in The Gambia and enrolled 279 babies, but wa…

This study tested whether adding the targeted drug inotuzumab ozogamicin before and after a stem cell transplant could help control leukemia and lymphoma. It included 15 people aged 12 to 75 with certain blood cancers. The study was stopped early, but researchers looked at safety…

This study tested a drug called XmAb23104 in people with advanced sarcoma, a rare cancer. The goal was to see if the drug could shrink tumors and if it was safe. Only 6 people took part before the study was ended early.

This study tested a drug called IgPro20 (HIZENTRA) to see if it could help people with post-COVID POTS, a condition that causes a rapid heart rate and dizziness when standing. The trial was stopped early after enrolling only 16 adults. The goal was to see if the drug could reduce…

This study looked at how feminizing hormone therapy (estradiol) interacts with HIV medications in transgender women living with HIV. It included 93 participants who were already on HIV treatment and gave them standardized estradiol doses for up to 48 weeks. The goal was to see if…

This study tested a mix of drugs (cyclophosphamide, sirolimus, low-dose IL-2, and azacitidine) to treat severe graft-versus-host disease that didn't respond to steroids. Only 3 patients were enrolled before the trial was stopped early. The goal was to see if the treatment could c…

This study looked at whether different medications for opioid use disorder (methadone, buprenorphine/naloxone, or naltrexone) could reduce immune system inflammation in people with HIV. Researchers measured changes in blood markers of immune activation over 24 weeks. The trial wa…

This study tested two antiviral drugs, clevudine and tenofovir, alone or together, in 150 adults with chronic hepatitis B who had not been treated before. The goal was to see which approach worked best at controlling the virus after 96 weeks of treatment and 24 weeks of follow-up…

This study tested a cold atmospheric plasma device on children aged 4-21 with warts or molluscum lesions. The device uses ionized gas to treat the lesions without heat. The trial was terminated early, so we don't have full results on how well it worked or its safety.

This study tested whether switching to a two-drug HIV treatment (raltegravir plus maraviroc) could reduce belly fat (lipohypertrophy) in people whose HIV was already well-controlled. It included 48 adults on stable HIV therapy for at least 5 years. The study was stopped early, so…

This phase 2 trial tested the drug lenalidomide in 12 people with HIV who had Kaposi sarcoma, a type of cancer. Participants took lenalidomide pills for 21 days each month. The study aimed to see if the drug could shrink tumors, but it was stopped early, so the results are not co…

This early-stage trial tested a combination of two immune-boosting drugs—pembrolizumab (Keytruda) and CMP-001—in 14 adults with lymphomas that had come back or stopped responding to treatment. The goal was to find a safe dose that could shrink tumors. However, the study was termi…

This early-phase trial tested a new drug called nanrilkefusp alfa, which helps activate immune cells, both alone and combined with the immunotherapy pembrolizumab. It included 115 people with various advanced solid tumors that had stopped responding to standard treatments. The st…

This study tested a combination of three drugs (ruxolitinib, uhCG/EGF, and steroids) in 10 people with a severe form of acute graft-versus-host disease (aGVHD), a complication that can occur after a stem cell transplant. The goal was to find the lowest effective steroid dose to r…

This study tested whether imatinib, a drug used for certain cancers, could help hospitalized adults with COVID-19. Participants received either imatinib or a placebo alongside standard care. The trial was stopped early and only included 21 people, so no firm conclusions can be dr…

This study tested whether breathing in nitric oxide gas could keep mild-to-moderate COVID-19 from becoming severe. Researchers enrolled 62 hospitalized adults who were breathing on their own. The goal was to see if the gas reduced the need for a breathing tube. The trial was stop…

This small Phase 2 trial tested an experimental drug called Auxora in 10 patients with critical COVID-19 pneumonia who were on ventilators. The goal was to see how the drug affected immune cells in the lungs and to check its safety. The study was terminated early, so results are …

This study tested a drug called belantamab mafodotin (Blenrep) in 10 people with rare, aggressive lymphomas that had come back or not responded to treatment. The drug is an antibody-drug conjugate designed to target and kill lymphoma cells. The trial was terminated early, so the …

This study tested a new medicine, GSK3915393, in 158 people with idiopathic pulmonary fibrosis (IPF), a chronic lung disease that causes scarring and breathing difficulty. The goal was to see if the drug could slow lung function decline compared to a placebo. The trial was termin…

This early-phase trial tested a new therapy called ATA3219, which uses immune cells from a healthy donor to attack cancer cells in people with relapsed or refractory B-cell non-Hodgkin lymphoma. The study aimed to check safety and see if the treatment works, but it was stopped ea…

This phase 2 study tested a treatment called brexucabtagene autoleucel, a CAR T-cell therapy made from a patient's own immune cells, for four rare B-cell cancers: Waldenstrom macroglobulinemia, Richter transformation, Burkitt lymphoma, and hairy cell leukemia. The trial enrolled …

This study compared two antiviral medicines (oral valganciclovir and topical ganciclovir 2%) against a placebo for treating CMV-related inflammation in the front of the eye. The goal was to see which approach better controls the infection and reduces complications like pain, glau…

This study tested whether using a urine biomarker test (NephroCheck) to guide treatment could reduce kidney injury, dialysis, or death in sepsis patients. The trial planned to enroll many participants but was stopped early after only 19 people joined. The idea was to catch kidney…

This study tested a drug called PRO1160 in people with advanced kidney cancer, nasopharyngeal cancer, or non-Hodgkin lymphoma. The goal was to find a safe dose and see if the drug shrinks tumors. The trial was stopped early, so results are limited.

This phase 2 trial tested whether adding aprepitant, a drug usually used for nausea, to standard care could help hospitalized COVID-19 patients recover faster. The study planned to enroll adults recently admitted to the hospital with COVID-19 and signs of lung involvement. Howeve…

This study tested a drug called tislelizumab, which helps the immune system fight cancer, against standard chemotherapy in people with Hodgkin lymphoma that returned or didn't respond to treatment. Only 3 people took part before the study was stopped early. Because of this, we do…

This study looked at two different antibiotic combinations for treating early syphilis in people living with HIV. One group received a single shot of ceftriaxone plus a week of doxycycline pills, while the other got the standard single shot of penicillin plus the same doxycycline…

This early-phase trial tested the drug ASTX660 in just 8 people with T-cell lymphoma that had returned or not responded to prior treatments. The study aimed to find a safe dose and check for side effects, but it was stopped early. Because it was so small and incomplete, we cannot…

This study aimed to see if Hiprex (methenamine hippurate) could reduce recurrent urinary tract infections in women aged 50 to 85. Participants took Hiprex daily for a year, and researchers counted infections and antibiotic use. However, the trial was terminated early with only 14…

This study tested whether adding reparixin to standard care could prevent death or the need for a breathing machine in 414 hospitalized adults with COVID-19 or other pneumonia. The trial was stopped early. Researchers compared reparixin to a placebo to see if it reduced severe ou…

This pilot study tested whether the drug ruxolitinib could be used as the first treatment for chronic graft-versus-host disease (cGVHD) in children and young adults, instead of the usual high-dose steroids. The goal was to see if it could control the disease while avoiding steroi…

This study tested a new therapeutic vaccine (GSK3528869A) in adults aged 18-65 with chronic hepatitis B whose virus was already well-controlled by standard antiviral pills. The goal was to see if the vaccine could safely lower hepatitis B surface antigen levels and possibly allow…

This early-stage trial tested an oral drug called HMPL-523 in 69 people with lymphoma that had returned or stopped responding to other treatments. The main goals were to check safety and find the right dose. The study was terminated early, so we have limited information on how we…

This early-stage trial tested a new drug, QEQ278, in 30 adults with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check the drug's safety and find the right dose. The study was stopped early, so results are limited.

This phase 2 trial tested inotuzumab ozogamicin (Besponsa) in children with B-cell acute lymphoblastic leukemia who had low levels of remaining cancer cells (MRD) despite treatment. The drug targets CD22, a protein on leukemia cells, and delivers a potent toxin. Only 5 children w…

This early-phase study tested whether a special type of cell (interferon gamma-primed mesenchymal stromal cells) could be safely given to prevent graft-versus-host disease, a common and serious complication after bone marrow transplant. Only 4 patients with acute leukemia or myel…

This study aimed to find the best way to help transgender women living with HIV reach undetectable viral levels. Participants received either text messages, help from a peer health navigator, or both. The trial was ended early, so results are limited.

This study tested the drug tocilizumab (Actemra) in hospitalized adults with severe COVID-19 and signs of inflammation. Participants received either the drug or a placebo, with the goal of improving clinical status by day 28. The trial was terminated early after enrolling only 20…

This study looked at 500 adults with septic shock and severe acute kidney injury to see if starting dialysis early (within 12 hours) or waiting (48-60 hours) affected survival at 90 days. The trial was terminated early, so the results are not conclusive. The goal was to find the …

This study tested the drug vixarelimab against a placebo in people with idiopathic pulmonary fibrosis (IPF) or systemic sclerosis-associated interstitial lung disease (SSc-ILD). The goal was to see if it could preserve lung function over 52 weeks. The trial was terminated early, …

This early-phase study tested a radioactive drug called 225Ac-SSO110 combined with standard immune checkpoint inhibitors for people with advanced small cell lung cancer or Merkel cell carcinoma. The goal was to check safety and find the right dose. However, the trial was terminat…

This study tested whether hydroxychloroquine (a malaria drug) could help hospitalized COVID-19 patients recover faster. It planned to enroll 350 people but was stopped early with just 17 participants. Because it ended so early, we cannot say whether the drug works or is safe for …

This study tested whether a sedative drug called dexmedetomidine could help restore blood pressure control in patients with severe septic shock that does not respond to standard treatments. The trial involved 32 adults in intensive care. The goal was to see if the drug could impr…

This study tested whether metformin (a diabetes drug) and doxycycline (an antibiotic) could help treat head and neck cancer when taken before surgery. The trial aimed to see if these drugs could change certain proteins in the tumor's supportive tissue. Only 7 people took part bef…

This study tested a single dose of ensovibep, a lab-made protein, in 407 adults with mild COVID-19 symptoms. The goal was to see if it could lower the amount of virus in the body and reduce hospitalizations. The trial was stopped early, so we don't have complete answers on how we…

This study tested a daily probiotic supplement containing Lactobacillus plantarum, cranberry, and vitamin C to see if it could prevent recurrent urinary tract infections (UTIs) in women. The trial planned to enroll 106 women with a history of frequent UTIs, but it was terminated …

This study tested a new drug, PF-08046045, in 22 adults with advanced lymphomas (cancers of the immune system). The goal was to find a safe dose and check for side effects. The trial was stopped early, so results are limited.

This study tested whether a medicine called emetine could help adults aged 30 and older recover from COVID-19. Participants took emetine or a placebo daily for 10 days. The trial was stopped early after only 4 people enrolled, so we don't have enough information to know if emetin…

This early-stage study tested a new medicine called RO7565020 in healthy volunteers and people with chronic hepatitis B. The goal was to see if the drug is safe and how the body processes it. The trial was stopped early, so results are limited.

This study tested a new eye drop (rhPRG4) in 3 adults with moderate to severe dry eye from chronic graft-versus-host disease (GVHD), a complication of bone marrow transplants. The goal was to see if the drops safely improve dryness and eye surface damage. The trial was terminated…

This early-phase trial tested an experimental drug called TAK-500, alone or with the immunotherapy pembrolizumab, in 61 adults with advanced solid tumors like pancreatic, liver, and lung cancer. The main goals were to check safety and see if the drug could shrink tumors. The stud…

This early-phase trial tested two immunotherapy drugs, ipilimumab and nivolumab, in people with HIV who had advanced solid tumors or Hodgkin lymphoma that had spread or come back. The goal was to find the safest dose and see if the combination could shrink tumors. The study was t…

This study tested whether the antibiotic ceftolozane-tazobactam, guided by a rapid molecular test, could effectively treat serious Pseudomonas aeruginosa infections in people with blood cancers or those who had a stem cell transplant. The 17 participants received the antibiotic t…

This early-phase trial tested an experimental drug called OC-001, given alone or with the immunotherapy avelumab, in 73 people with various advanced or metastatic cancers (like lung, breast, and bladder cancer). The main goals were to check safety and how the drug moves through t…

This Phase 2 trial tested an experimental drug called ARC-520 in 58 people with chronic hepatitis B who were already taking standard antivirals. The goal was to see if ARC-520 could further lower hepatitis B surface antigen levels, a marker of the virus. The study was terminated …

This study tested a new drug called ARC-520 in 79 people with chronic hepatitis B. Some participants received ARC-520 alone, while others got it combined with standard treatments like entecavir or tenofovir. The goal was to see if ARC-520 could lower hepatitis B surface antigen l…

This early-stage study tested an experimental drug called ARC-521 in healthy volunteers and people with chronic hepatitis B. The main goal was to check safety and how the body processes the drug. The study was terminated early, so results are limited.

This study tested new single treatments for idiopathic pulmonary fibrosis (IPF), a lung disease that causes scarring and makes breathing hard. It included 46 adults aged 40 and older with mild to moderate IPF. The main goal was to see if the treatments improved lung function, mea…

This study tested an experimental drug called ARC-520 given alongside standard hepatitis B medications (entecavir or tenofovir) in 12 people with chronic hepatitis B. Participants received 9 doses of ARC-520 over 36 weeks to see if it could safely lower hepatitis B virus levels. …

This study tested whether a new drug called ARC-520, given with the standard medicine entecavir, could lower hepatitis B virus levels in people with chronic hepatitis B. About 58 adults with different stages of infection received either ARC-520 or a placebo. The study was stopped…

This study tested an experimental drug called ARC-520 in 32 adults with chronic hepatitis B who were already taking antiviral medications (entecavir or tenofovir). The goal was to see if adding ARC-520 could lower hepatitis B surface antigen levels more than placebo. The trial wa…

This early-phase study aimed to see if combining two immune-stimulating drugs (rintatolimod and interferon alpha-2b) could help cancer patients fight off COVID-19. Only 4 people took part before the study was stopped early. The main goals were to check safety and measure how the …

This study tested a new, easy-to-dissolve malaria tablet in infants and newborns weighing less than 5 kg who had uncomplicated malaria. The goal was to see how the medicine worked in the body, how safe it was, and how well it treated the infection. The trial was stopped early aft…

This early-stage trial tested a combination of two drugs, APG-1387 and toripalimab, in 40 people with advanced solid tumors including colorectal, nasopharyngeal, and lung cancers. The goal was to find a safe dose and see if the combination could control the disease. However, the …

This Phase 2 trial tested the drug silmitasertib (CX-4945) plus standard care in adults with pneumonia caused by COVID-19 or influenza. The goal was to see if the drug could reduce the need for hospitalization or prevent death. The study planned to enroll 120 people but was termi…

This study tested whether intense pulsed light (IPL) can help treat chalazion, a common eyelid lump. Only 4 adults with a fresh chalazion were enrolled, and the trial was stopped early. Because of the very small size, we cannot say if IPL works or is safe for this condition.

This study tested whether giving antibiotics early to ICU patients who may have inhaled stomach contents could prevent pneumonia and improve recovery. Only 5 patients were enrolled before the trial was stopped early. The results are too limited to draw any conclusions about wheth…

This study tested the safety and dosing of sisunatovir, an experimental antiviral drug, in infants and children up to 5 years old with RSV lower respiratory tract infection. Ten participants received either the drug or a placebo. The goal was to find the right dose for future stu…

This study tested a new drug called SAR444245, alone or with pembrolizumab, in 14 people aged 12 and older with B cell lymphoma that came back or didn't respond to treatment. The goal was to see if the drug could shrink tumors. The study was terminated early, so results are limit…

This study tested a complete kit using povidone-iodine (Betadine) gel, soap, and mouthwash to clear MRSA bacteria from patients' noses, skin, and mouths. The goal was to see if the kit could quickly decolonize MRSA within 6 hours. However, the trial was terminated early after enr…

This study tested whether shining a special UV light inside the mouth could help people with painful mouth sores caused by graft-versus-host disease after a stem cell transplant. Only 11 people took part, and the study was stopped early. The goal was to see if the light treatment…

This study tested a new oral antifungal drug, ibrexafungerp, for treating serious Candida infections in the blood or internal organs. 68 adults received an IV antifungal followed by either ibrexafungerp or standard oral fluconazole. The trial was stopped early, so the results are…

This study tested the drug baricitinib in children aged 1 to 18 who were hospitalized with COVID-19 and needed extra oxygen. The goal was to see if the drug was safe and how it worked in kids. Only 6 children took part before the study was stopped early.

This study tested three different antibiotic regimens for people with recurrent Clostridium difficile infection (C. diff), a serious gut infection that keeps coming back. The goal was to see if newer drugs like fidaxomicin or a tapered/pulsed course of vancomycin work better than…

This phase 3 trial tested whether the antiviral drug ganciclovir could prevent reactivation of cytomegalovirus (CMV) in adults with sepsis who needed a breathing machine. The study enrolled 205 CMV-positive patients in the ICU with acute respiratory failure. Participants received…

This study tested a drug called ADCT-602 in 37 people with a type of blood cancer (B-cell acute lymphoblastic leukemia) that had returned or stopped responding to other treatments. The drug is a lab-made antibody that targets a protein (CD22) on cancer cells to stop them from gro…

This early study tested a device that places radioactive seeds directly into skin, mouth, or soft tissue tumors. The seeds release alpha radiation to kill cancer cells from within. Only 2 people took part before the trial was stopped, so we don't have enough information to know i…

This study tested a treatment called HepTcell, which is like a vaccine that trains the immune system to fight the hepatitis B virus. It was for people with inactive chronic hepatitis B who had not received treatment before. The goal was to see if it could lower virus levels or cl…

This study tested a blood product called immune globulin (Flebogamma) in 191 people with post-polio syndrome, a condition causing new muscle weakness years after polio. The goal was to see if it could improve walking distance and reduce pain. The trial was terminated early, so we…

This study tested a drug called fostamatinib to help people whose blood cell counts drop after a stem cell transplant. The goal was to see if the drug could raise red blood cells or platelets without needing transfusions. The trial was stopped early after enrolling only one perso…

This study tested an experimental drug called HZN-825 in people with idiopathic pulmonary fibrosis (IPF), a lung disease that causes scarring and makes breathing hard. The trial aimed to see if the drug could slow the decline in lung function over a year. About 153 adults with IP…

This study tested whether a rapid lab test (looking for integrons in urine) could help doctors choose a narrow-spectrum antibiotic instead of a broad-spectrum one for children with fever and a urinary tract infection. The goal was to see if this approach works as well as standard…

This study tested an experimental drug called ABX464 in 509 high-risk COVID-19 patients aged 65 and older, or those 18+ with risk factors like obesity or diabetes. The goal was to see if the drug could reduce inflammation and prevent the need for high-flow oxygen or a breathing m…

This study tested whether adding fomepizole to the standard treatment (N-acetylcysteine) could better protect the liver in people who took too much acetaminophen (Tylenol). The trial included 29 adults and children aged 10 and older who were at high risk for liver injury. The goa…

This early-phase trial tested a new treatment called BT-001, a virus designed to infect and kill cancer cells, given alone or with the immunotherapy drug pembrolizumab. The study involved 31 people with advanced solid tumors like melanoma, lung cancer, or sarcoma that had spread.…

This study tested an oral antiviral drug called ensitrelvir in hospitalized COVID-19 patients. The goal was to see if it could help them recover faster. However, the trial was stopped early, so we have limited information on whether it works.

This study tested a new drug called REC-3964 to see if it could prevent repeat Clostridioides difficile (C. diff) infections in adults. Only 3 people were enrolled before the trial was stopped early. The goal was to check safety and whether the drug helped people stay infection-f…

This early-stage trial tests two experimental vaccines, HB-502 and HB-501, designed to teach the immune system to recognize and attack HIV. The study includes 30 people with HIV who are already on suppressive antiretroviral therapy. Participants receive injections every 8 weeks f…

This study tested whether the drug heme arginate can help transplanted kidneys work right away, instead of being slow to start. It included 47 adults receiving a kidney from a deceased donor. Participants got either the drug or a salt water solution at transplant and 24 hours lat…

This study tested an experimental drug called LAU-7b in adults hospitalized with COVID-19 who had health issues like diabetes that put them at higher risk for complications. The goal was to see if LAU-7b could prevent respiratory failure or the need for a breathing machine. The t…

This phase 3 study tested an inhaled form of the antibiotic clofazimine added to standard therapy for people with MAC lung disease that did not respond to previous treatment. The goal was to see if the drug could clear the infection from sputum cultures and improve quality of lif…

This study looked at whether weekly injections of PRO 140, taken with standard HIV medications, could keep the virus under control over the long term. It enrolled 43 people who had already completed an earlier PRO 140 study and had undetectable virus levels. The study was termina…

This study tested whether a once-daily extended-release form of tacrolimus (Envarsus XR) combined with azathioprine could work as well as the standard twice-daily tacrolimus plus mycophenolate in preventing kidney transplant rejection. The trial planned to enroll 20 adults receiv…

This study tested a bone marrow transplant using a partially matched family donor for people with blood cancers like leukemia. The goal was to see if a milder conditioning regimen and a drug called cyclophosphamide could help patients survive at least 180 days after transplant. T…

This study tested an oral drug called sisunatovir for treating RSV in adults who were not hospitalized but had a high risk of severe illness. Participants took either the drug or a placebo for 5 days. The study was terminated early, so results are limited.

This study tested whether adding rapamycin to high-dose chemotherapy could help people with aggressive blood cancers (like certain leukemias and lymphomas) that had returned or not responded to prior treatment. Only 4 adults aged 18–65 took part before the study was stopped early…

This study tested an experimental drug called ARC-520 in people with chronic hepatitis B who were already taking standard antiviral medications. The goal was to see if ARC-520 could further lower hepatitis B surface antigen levels. Only 4 people enrolled before the study was stop…

This study tested a drug called itacitinib combined with steroids to treat acute graft-versus-host disease (aGVHD) in children. aGVHD is a serious complication where donor immune cells attack the child's body after a stem cell transplant. The trial was stopped early after enrolli…

This study tested whether HIV patients who already had the virus under control could switch to weekly injections of leronlimab (PRO 140) instead of their usual daily pills. The goal was to see if the drug alone could keep the virus suppressed safely over a longer period. The tria…

This early-stage study tested a new antibody drug (REGN14256) alone or with imdevimab in 25 adults with mild COVID-19 and no risk factors for severe illness. The goal was to check safety and whether the drug could lower virus levels. However, the trial was terminated early, so we…

This early-phase trial tested a new immunotherapy approach for children with DIPG, a rare and aggressive brain stem tumor. After standard radiation and chemotherapy, patients received special vaccines and immune cells designed to attack the tumor. The study was small (11 particip…

This study tested two experimental drugs, budigalimab and ABBV-382, in people with HIV who were stable on standard therapy. Participants stopped their usual HIV medications to see if the new drugs could keep the virus under control. The trial was terminated early, so it's unclear…

This study tested a lab-made antibody called SCTA01 in adults hospitalized with severe COVID-19. The goal was to see if it could help them recover faster. The trial was stopped early, so we don't have clear results on its effectiveness.

This study tested a new treatment called CTX110 for people with B-cell blood cancers that came back or didn't respond to standard therapy. CTX110 uses donor immune cells that are edited with CRISPR technology to target and attack cancer cells. The trial enrolled 93 adults and aim…

This was a small, early-phase study testing an experimental HIV drug called GS-1219 in just 4 people living with HIV-1. The goal was to check the drug's safety and how well it fights the virus. The study was terminated early, so results are very limited.

This study tested a program to help Virginia Medicaid enrollees with HIV fill their antiretroviral prescriptions on time. The program offered support from providers, pharmacies, and community groups, with extra help for those who were very late refilling. Only 4 people enrolled b…

This study looked at the long-term safety of efgartigimod in adults with post-COVID postural orthostatic tachycardia syndrome (POTS), a condition causing rapid heart rate and dizziness upon standing. The trial was an open-label extension for people who completed a previous study.…

This early-phase trial tested whether adding the drug itacitinib to standard immune-suppressing medications could help prevent graft-versus-host disease (GVHD) in people receiving stem cell transplants for blood cancers. The study enrolled 84 participants with leukemia, lymphoma,…

This study tested whether adding an immune-boosting drug (NT-I7) to a standard immunotherapy (atezolizumab) could help people with advanced skin cancers like melanoma, Merkel cell carcinoma, and squamous cell carcinoma. The trial included 31 adults whose cancer had not responded …

This study tested an experimental HIV drug called VH3739937 in 21 adults with HIV who had never taken HIV medication before. The goal was to see how well the drug lowered the virus level in the blood over a short time. The trial was stopped early, and results are limited.

This study tested whether adding itacitinib (an anti-inflammatory drug) to standard steroid treatment could help people with moderate to severe chronic graft-versus-host disease (cGVHD), a complication after stem cell transplants. The trial enrolled 155 participants but was termi…

This Phase 2 trial tested apraglutide, a drug that helps repair the gut lining, in 31 people with severe gastrointestinal graft-versus-host disease (GVHD) after a stem cell transplant. Participants had GVHD that did not respond to steroids. The study aimed to see if apraglutide i…

This study tested a single injection of two lab-made antibodies (casirivimab and imdevimab) in children under 12 who are at high risk for severe COVID-19. The goal was to see how the drug behaves in the body, if it is safe, and if it triggers an immune response. Only 7 children t…

This early-stage study tested an experimental drug called INCB099318 in people with advanced solid tumors that had stopped responding to standard treatments. The main goal was to check the drug's safety and how the body processes it. The study was terminated early, so results are…

This study tested a single dose of casirivimab+imdevimab (REGN-COV2) in children hospitalized with COVID-19. The goal was to see how the drug behaves in the body and whether it is safe. However, the study was terminated early and only enrolled 2 participants, so we have very litt…

This study tested whether a single antibody called PRO 140 could keep HIV under control in 20 adults who had been stable on standard combination therapy. Participants stopped their usual HIV pills and received only PRO 140 infusions. The trial was stopped early, and the main goal…

This study looked at whether adding the immunotherapy drug nivolumab to standard chemotherapy could help people with nasopharyngeal cancer that has returned or spread. The trial was planned for many participants but was stopped early, so only 15 people took part. Because of the e…

This study looked at a new way to prevent severe graft-versus-host disease (GVHD) in children who had a bone marrow transplant for blood cancers. The goal was to see if stopping certain immune-suppressing drugs after day 60 could lower the risk of severe GVHD. Only 3 children too…

This study tested a drug called Cytotect, which contains antibodies against the CMV virus, to prevent CMV infection in people who had a stem cell transplant and developed graft-versus-host disease (GVHD). These patients are at high risk for CMV, and current antiviral drugs often …

This study tested whether infusions of stem cells from donated fat tissue could help people with COVID-19. The trial planned to enroll 48 adults and compare four doses of stem cells against a placebo. The goal was to see if the treatment could reduce inflammation and improve oxyg…

This early-stage trial tested a new drug called GEN3017 in 9 people with CD30-positive lymphomas (Hodgkin and non-Hodgkin) that had returned or stopped responding to standard treatments. The drug was given as a shot under the skin. The main goals were to check safety and find the…

This study tested whether the oral drug midodrine could help people with septic shock stop needing IV blood pressure support sooner. The trial planned to enroll many patients but was stopped early with only 10 participants. Because it was so small, we cannot draw firm conclusions…

This early-phase study tested whether hydroxychloroquine, a drug used for malaria and autoimmune diseases, could reduce the amount of virus in adults with mild COVID-19 not needing oxygen. Only 8 people took part before the trial was stopped early. The study was too small to draw…

This study tested a new pill combining two drugs (albendazole and ivermectin) to treat several types of intestinal worms in children and young adults aged 5 to 18. The goal was to see if the combination worked better than the standard single drug. However, the trial was terminate…

This early-stage trial tested two drugs, isatuximab and cemiplimab, together in 58 people with relapsed or refractory lymphoma. The goal was to see if the combination was safe and could shrink tumors. The study was terminated early, so while some safety and response data were col…

This study tested the antibiotic teicoplanin (taken by mouth twice daily for 7 to 14 days) in 50 adults hospitalized with C. difficile infection causing diarrhea and colitis. The goal was to see if it could stop diarrhea and prevent it from coming back. The trial was terminated e…

This study tested a drug called fosmanogepix in 21 adults with invasive mold infections (like Aspergillus or rare molds) who had few other options. The trial was stopped early, so we have limited data on how well it works or its safety.

This phase 3 trial tested whether a combination inhaler (fluticasone and salmeterol) could improve lung function in children aged 6–17 who had a drop in breathing capacity after a stem cell transplant. The study aimed to prevent bronchiolitis obliterans, a serious lung complicati…

This phase 3 trial tested whether a dose of the Janssen COVID-19 vaccine could boost immunity in kidney transplant recipients who had already received two or three mRNA vaccine doses. The study enrolled 468 participants and also looked at reducing immunosuppression medication. Ho…

This study looked at whether breathing pure oxygen in a pressure chamber (hyperbaric oxygen therapy) can help heal jaw damage caused by radiation treatment for cancer. The trial planned to include 20 people with jaw bone decay, but it was stopped early. The goal was to see if the…

This study tested a nasal spray called AD17002 in 180 adults with mild to moderate COVID-19. Participants received either a low dose, high dose, or placebo spray alongside standard care. The goal was to see if the spray speeds up recovery and improves symptoms. However, the trial…

This study tested leflunomide, a drug used for rheumatoid arthritis, as a first-line treatment for musculoskeletal graft-versus-host disease (GVHD), a complication of bone marrow transplants where donor cells attack the patient's muscles and joints. The goal was to see if lefluno…

This study tested whether a single infusion of stem cells from umbilical cord tissue (ProTrans®) could help hospitalized adults with severe COVID-19 avoid ventilators or death. The trial was stopped early after enrolling only 19 people, so we cannot draw firm conclusions. Both th…

This phase 2 trial tested whether adding trilaciclib (Cosela) to standard chemotherapy and avelumab could help people with advanced bladder cancer by protecting their bone marrow. The study enrolled 92 adults with untreated, locally advanced or metastatic urothelial carcinoma. Un…

This small phase 2 trial tested whether giving hepatitis B antibodies (HBIG) could clear the hepatitis B surface antigen in people with chronic hepatitis B. Only 13 patients were enrolled before the study was terminated. The goal was to see if a 12-week course of injections could…

This study tested a drug called saroglitazar magnesium for nonalcoholic fatty liver disease (NAFLD) in people with HIV. The trial aimed to see if the drug could reduce liver fat over 24 weeks. However, the study was terminated early and only enrolled 4 participants, so no meaning…

This study tested a new imaging tool called multispectral optoacoustic tomography (MSOT) to see if it could safely detect inflammation in people with graft-versus-host disease, Crohn's disease, or colitis. The device uses light and sound to create images of inflamed areas. The tr…

This Phase II study tested a radioactive tracer called 68GaNOTA-Anti-MMR-VHH2 to see if it can light up certain immune cells (macrophages) on PET scans. The trial included 29 people with head and neck cancer, lymphoma, atherosclerosis, or sarcoidosis. The goal was to see if the t…

This study looked at using a fast, point-of-care COVID-19 test to help doctors quickly decide how to treat patients with serious heart or breathing problems. It involved 66 adults who already tested positive for COVID-19. The goal was to find the best way to collect samples (nose…

This study explored whether analyzing sweat from fingerprints using a special camera could quickly detect COVID-19. Researchers enrolled 66 adults who had tested positive or negative for COVID-19 within the past week. Participants provided a fingerprint sweat sample and a blood s…

This study looked at whether changes in gene activity in blood cells can help doctors tell the difference between a normal inflammatory response after major surgery and a serious infection. Researchers planned to enroll 61 adults undergoing high-risk noncardiac surgery. The study…

This study tested whether a one-minute sit-to-stand test could help emergency doctors decide if COVID-19 patients need hospital care. The test measures oxygen levels and breathing effort during repeated standing from a chair. The trial aimed to reduce unnecessary hospital stays b…

This study tested whether a special PET scan using a tracer called 68Ga-PentixaFor could predict how well patients with central nervous system lymphoma respond to chemotherapy. The plan was to scan patients before, during, and after treatment and see if the scan results matched t…

This study tested whether using stitches coated with an antibacterial agent (triclosan) could reduce infections after cesarean delivery. Over 1,100 women were planned to take part, but the trial was stopped early. Because it was terminated, we cannot draw firm conclusions about w…

This study tested whether Alkagin paste could prevent skin damage in patients receiving radiation for anal, rectal, or gynecological cancers. Only 2 people enrolled before the trial was stopped early. Because of this, we cannot draw any reliable conclusions about the paste's effe…

This study tested a once-monthly pill called islatravir to prevent HIV infection in cisgender men and transgender women who have sex with men and are at high risk. About 494 participants were enrolled, but the trial was terminated early. The main goal was to check safety and see …

This study tested a special multi-line device (Edelvaiss Multiline NEO) to see if it could prevent bloodstream infections in very premature infants (24-29 weeks) who need IV medications and nutrition. The device was compared to standard infusion sets. Unfortunately, the trial was…

This study explored whether giving the HPV vaccine in the emergency department (ER) could help protect adults aged 18-45 who haven't been fully vaccinated. Researchers enrolled 34 participants and offered the vaccine during their ER visit, with follow-up doses at 2 and 6 months. …

This study tested a mobile-friendly tool that helps young Black men and transwomen who have sex with men or transwomen pick the best HIV testing method for them, such as self-testing or clinic testing. The goal was to see if this personalized recommendation could increase how oft…

This pilot study tested the blood pressure drug telmisartan (Micardis) to prevent acute graft-versus-host disease (GVHD) in people receiving a stem cell transplant for blood cancers. The trial aimed to enroll 60 participants but was terminated early with 32. Researchers tracked s…

This study tested whether breathing in nitric oxide gas could prevent healthcare workers from catching COVID-19. The plan was to enroll 470 workers, but the trial was stopped early with only 24 participants. Workers in the treatment group inhaled the gas at the start and end of e…

This trial tested a method to control mosquito-borne diseases like dengue, Zika, and chikungunya by releasing male Aedes aegypti mosquitoes infected with Wolbachia bacteria. These males mate with wild females, causing their eggs to die, which reduces the mosquito population. The …

This study tested a program to help HIV-negative transgender women and men who have sex with men who also have a substance use disorder stick with PrEP, a daily pill or shot that prevents HIV. Participants received counseling and text support, with extra help for those who strugg…

This study tested a new monthly pill (islatravir) to see if it could prevent HIV infection better than a daily pill in 730 women at high risk. The trial was stopped early, so results are limited. The goal was to offer a more convenient prevention option.

This study aimed to see if a single dose of the BCG vaccine could prevent tuberculosis infection in healthy adults traveling to countries with high TB rates. Participants were randomly assigned to receive either BCG or a placebo. The study was terminated early and enrolled only 1…

This study tested whether a high-dose flu vaccine works better than the standard dose in preventing the flu in children aged 6 to 35 months. About 100 children took part, receiving either the high-dose or standard-dose shot. The study was stopped early, so results are limited.

This study tested whether a combination of antibodies (casirivimab+imdevimab) could prevent COVID-19 in people with weakened immune systems, such as transplant recipients or cancer patients. Participants received either the antibodies or a placebo as a shot under the skin. The tr…

This study tested whether a nitric oxide nasal spray could prevent COVID-19 in people at risk of exposure. About 1,400 adults used the spray or a placebo for 28 days. The trial was terminated early, so final results are not available.

This study compared a high-dose flu vaccine to the standard-dose shot in over 33,000 adults aged 65 and older. The goal was to see if the high-dose version could better prevent hospitalizations for heart and lung problems. The trial was terminated early, so the full picture is no…

This study tested whether adding vaccine discussions to routine behavioral health visits could reduce hesitancy and increase COVID-19 and flu shots among Latinx adults with mental illness. Clinicians used motivational interviewing and could offer a warm handoff to a nurse for vac…

This study tested whether a daily pill used for HIV (TAF/FTC) could prevent COVID-19 in healthcare workers at high risk of exposure. Over 1,300 workers were randomly assigned to get the drug or a placebo for 12 weeks. The trial was stopped early, so it's unclear if the drug had a…

This study compared a newer recombinant flu vaccine (RIV4, also called Supemtek or Flublok Quadrivalent) to the standard egg-based flu vaccine in 366 children aged 3 to 8 years. The goal was to see if the recombinant vaccine produced a similar immune response and was as safe. The…

This study tests whether the drug pregabalin, alone or with a rehabilitation program, can reduce chronic fatigue in people with post-COVID syndrome. Participants are adults aged 18 to 65 who had COVID-19 at least six months ago and still feel very tired. The trial compares four g…

This study tested an oral antiviral drug called obeldesivir in children from birth to under 5 years old who had RSV infection. The goal was to see if the drug is safe and helps reduce symptoms faster. However, the trial was stopped early and only enrolled 4 participants, so the r…

This study tested whether a group therapy program, led by trained youth leaders, could improve mental health and help young people with HIV stick to their medication. About 484 youth in low-resource settings took part. The program used trauma-informed counseling adapted to local …

This study looked at whether giving vitamin C to elderly patients hospitalized with pneumonia could improve their breathing and daily function. Only 9 people took part before the study was stopped early. Because it was so small, we can't say if vitamin C helps or not.

This study tested a smartphone app that teaches mindfulness meditation to help Black and Latino adults with anxiety during the COVID-19 pandemic. About 400 participants were assigned to one of two mindfulness programs or a waitlist. The trial was terminated early, so we don't hav…

This study tested whether the steroid methylprednisolone could improve memory and thinking in people with long COVID. About 96 adults with ongoing memory problems were to receive either the drug or a placebo for six weeks. The trial was terminated early, so we don't know if the t…

This study aimed to see if acceptance and commitment therapy (ACT), a type of talk therapy, could help HIV-positive men with mental health issues like stress and anxiety. Only one person enrolled before the study was stopped early. Because of this, no meaningful results were obta…

This study looked at whether a special protocol used by community pharmacists in France can help women with simple bladder infections (cystitis) get relief more quickly. The goal was to reduce symptoms and avoid unnecessary trips to the doctor or emergency room. The study include…

This study tested whether rinsing the nose and gargling with salt water could help people with suspected or confirmed COVID-19 feel better faster. Only 16 adults in the UK took part before the study was stopped early. The goal was to see if this simple home remedy could reduce ho…

This study tested whether a simple, 5-minute daily breathing exercise using a handheld device, combined with a personalized exercise plan, could improve heart health and fitness in people who have survived lymphoma. Only one person enrolled before the study was stopped, so no mea…

This study tested a cream called dermaprazole (a form of esomeprazole) to see if it could prevent or reduce skin burns caused by radiation therapy in women who had mastectomy for breast cancer. Only 3 women were enrolled before the trial was stopped early. The goal was to check s…

This study tested whether a gas sedative (isoflurane) could help patients with septic shock wake up and get off a breathing machine faster than standard IV sedation (midazolam). The goal was to reduce complications from long-term sedation and ventilation. Only one patient was enr…

This study tested whether synthetic cannabidiol (CBD) could help people living with HIV who have a condition called alexithymia, which makes it hard to recognize and describe emotions. Participants took either CBD or a placebo for 4 weeks. The goal was to see if CBD could improve…

This study tested an experimental drug called BI 1839100 in adults with idiopathic pulmonary fibrosis (IPF) or progressive pulmonary fibrosis (PPF) who have a chronic cough. Participants took different doses of the drug or a placebo for 12 weeks. The goal was to see if the drug c…

This study tested whether adding physical rehabilitation and personalized nutrition to standard care helps patients with infective endocarditis (a serious heart infection) feel better during their hospital stay. The goal was to improve mental health and quality of life. The study…

This small pilot study tested whether a traditional Chinese medicine called Xuanfei Baidu granules is safe and acceptable for people with mild to moderate COVID-19. Only 10 adults were enrolled before the study was stopped early. The main goal was to see how many people would agr…

This study aimed to see if taking NSAIDs (like naproxen) on a regular schedule could reduce arthritis symptoms and prevent long-term joint problems in people with Lyme disease. Only 3 participants were enrolled before the study was stopped, so no clear conclusions can be drawn. T…

This study looked at whether using the Calm meditation app could help medical residents and fellows at Banner University Medical Center Phoenix feel less stressed, anxious, or burned out during the COVID-19 pandemic. Only 7 people signed up, and the study was stopped early, so we…

This study compared two standard drugs—olanzapine and dexamethasone—for preventing nausea and vomiting caused by chemotherapy. Researchers wanted to see if olanzapine could work as well as the steroid dexamethasone, potentially allowing patients to avoid steroid side effects. The…

This study tested a small device that stimulates a nerve in the ear to see if it can reduce nausea and vomiting caused by chemotherapy in children, teens, and young adults. The device, called IBStim, was compared to a sham (fake) device. The trial was terminated early and include…

This study looked at whether a supervised exercise and pulmonary rehabilitation program could help people with Long COVID feel better and move more easily. Researchers measured changes in aerobic capacity, fatigue, and quality of life in 21 adults who had COVID at least 12 weeks …

This study tested a monthly solution called Tangible Boost that is meant to restore a special coating on contact lenses. The goal was to see if it could improve comfort and vision in people with severe dry eye from Stevens-Johnson syndrome, Sjogren's syndrome, or graft-versus-hos…

This study compared signs of aging in 123 HIV-infected adults to the general population. Researchers measured bone density, muscle strength, skin changes, and thinking abilities. The goal was to understand if HIV speeds up aging in these areas. No new treatment was tested; it was…

This study aimed to see if COVID-19 vaccines cause more side effects in cancer patients receiving immunotherapy. Researchers planned to track 125 patients from several hospitals in France, recording any local or systemic side effects. The study was terminated early, so the full r…

This study investigated whether polyomaviruses (a type of common virus) are found more often in people with autoimmune thyroiditis or goiters. Researchers compared virus presence in blood, urine, and thyroid tissue from 49 patients undergoing thyroid surgery. The goal was to see …

This study collected blood, urine, stool, and respiratory samples from 615 COVID-19 patients and caregivers at Bordeaux University Hospital. The goal was to build a biobank for research on the virus and disease. The study was terminated early, but the samples may still help scien…

This study looked for hidden brain damage in 38 hospitalized COVID-19 patients. Instead of using standard MRI scans, researchers used electrical tests to check how well the brainstem was working. The goal was to find subtle nervous system problems that might not show up on regula…

This study aimed to see if skipping a type of muscle relaxant during general anesthesia could lower the risk of serious lung complications in high-risk surgery patients. The trial was terminated early after enrolling only 3 participants, so no meaningful conclusions can be drawn.…

This study tested a web-based guide to help people have conversations about COVID-19. It enrolled 30 adults who spoke English or Spanish. The guide offered virtual conversations tailored to different concerns. The study was terminated early, so results are limited.

This study aimed to find the best dose of the antibiotic ceftriaxone for adults with urinary tract infections in the emergency department. Researchers measured how the drug behaves in the body to ensure it stays at effective levels long enough to kill bacteria. The study was stop…

This study looked at whether a weak immune response to bacteria in COPD patients leads to more lung infections and flare-ups. Researchers collected sputum, blood, and nasal swabs from 23 hospitalized COPD patients during a flare-up and again 8 to 16 weeks later. The goal was to m…

This study looked at whether a newer, low-dose X-ray system (EOSedge) produces images good enough for planning hip replacement or revision surgery, compared to standard digital X-rays. About 97 adults who needed hip surgery X-rays took part. The goal was to see if using just one …

This study looked at whether matching donor breast milk to a mother's secretor type could improve gut bacteria in very preterm infants. Researchers planned to compare matched versus standard donor milk in babies born before 34 weeks. The study was stopped early and included only …

This study followed 83 people with advanced non-small cell lung cancer who were starting standard treatments. The goal was to collect information to help develop a digital tool that can spot early signs of pneumonitis/ILD, a serious lung inflammation that can occur as a side effe…

This study looked at how the mpox virus spreads and how the immune system responds in people with advanced HIV. Researchers tracked the virus in different body samples and measured immune markers to better understand severe illness. The goal is to use these findings to improve tr…

This study tested a software platform called ICU Cockpit that collects and displays vital signs and other data from brain-injury patients in the intensive care unit. The goal was to help doctors make faster, better decisions and to predict complications like strokes or unstable c…

This was a first-in-human study to check the safety and how the body processes a single dose of GSK3494245, a potential treatment for leishmaniasis. It involved 59 healthy adults who received up to three increasing doses of the drug or a placebo. The study was terminated early, s…

This study used artificial intelligence to analyze electronic health records from 100,000 COVID-19 patients across multiple hospitals. The goal was to identify factors that predict whether a patient would be hospitalized, need ICU care, or die. The study was terminated early, so …

This study tested a web-based program to help Black women in Texas use HIV and STI home tests and connect to treatment or PrEP. The program included five sessions with goal-setting and action plans. Only 31 women enrolled before the study was stopped early, so the findings are li…

This study aimed to check how accurate several COVID-19 antibody tests are. Researchers used blood samples from 101 adults, including some taken before the pandemic and some from people with other infections. The goal was to see which tests best detect past COVID-19 infection.

This study looked for new markers in blood and joint fluid to help doctors tell the difference between septic arthritis (a joint infection) and juvenile idiopathic arthritis (an inflammatory condition) in children. Researchers planned to analyze samples from 100 children under 15…

This study looked at how the hepatitis B vaccine triggers immune cells called B cells to form germinal centers, where antibodies become stronger. Researchers wanted to understand if memory B cells return to these centers after a booster shot. The goal was to learn how to design b…

This study aimed to describe the features and natural history of idiopathic interstitial pneumopathy, a group of rare lung diseases, in both children and adults. Researchers planned to collect data from 1,600 participants, including medical history, imaging, and genetic tests, to…

This study aimed to see if a tiny camera on a thin tube (bronchoscopy) could help doctors diagnose diffuse lung diseases without needing a surgical lung biopsy. The camera takes live microscopic images of the air sacs. The study was stopped early, but it involved 38 adults with c…

This study tested whether raising the blood pressure target from 65 mmHg to 85 mmHg in patients with septic shock could help prevent kidney injury. Researchers used a drug called norepinephrine to adjust blood pressure and monitored kidney function. The trial was stopped early an…

This study tested a special vest that tracks health data like heart rate and breathing in people hospitalized with COVID-19. The goal was to see if the vest could help doctors spot worsening symptoms early. Only 15 adults took part before the study ended early.

This study looked at how immunosuppressive medications used for rheumatoid arthritis and spondyloarthritis affect the body's ability to fight COVID-19. Researchers measured viral load and immune responses in 150 patients and their infected family members. The goal was to understa…

This study looked at whether certain genetic differences in the immune system make some people more likely to develop severe bloodstream infections from E. coli or Staphylococcus aureus bacteria. Researchers planned to analyze blood samples from 60 patients to find mutations link…

This study looked at 500 patients with breast abscesses to see which first treatment works best: draining with a needle (aspiration) or making a small cut (incision and drainage). The goal was to find risk factors that lead to needing more than one treatment. The study was stoppe…

This study examined whether ride-sharing services like Uber and Lyft are linked to fewer alcohol- and drug-related car accidents and sexual assaults. Researchers collected data from trauma registries, transportation departments, and crisis centers in the Dallas area. The study wa…

This pilot study tested a new brain PET-MR scanner to see if it can capture clear images of brain metabolism and blood flow in people who had COVID-19 and those who did not. Only 3 participants were enrolled before the study ended early. The goal was to develop an imaging protoco…

This study aimed to find out whether one or three sessions of hyperbaric oxygen therapy works better to prevent long-term brain damage after carbon monoxide poisoning. Researchers planned to enroll adults with acute poisoning and test their memory, attention, and other thinking s…

This study aimed to find substances in blood and urine that could signal kidney damage earlier than current tests. Researchers compared samples from healthy volunteers, people with low fluid levels, those at high risk for kidney failure, and patients with acute kidney failure. Th…

This study looked at whether using a CPAP machine at night could reduce abnormal acid reflux and lung inflammation in people with idiopathic pulmonary fibrosis (IPF) who also have sleep apnea. Only 7 people enrolled before the study was terminated early. The goal was to measure c…

This study aimed to find a genetic link or family trait that connects people with Hidradenitis Suppurativa (HS), a painful skin condition. Researchers collected blood or saliva samples from 97 participants, including affected individuals and their family members, to analyze DNA f…

This study followed women who previously received 1 to 3 doses of an experimental Group B Strep (GBS) vaccine. The goal was to see how long their immune antibodies lasted by taking yearly blood samples for 2 to 5 years. No new vaccine or treatment was given—only observation.

This observational study aimed to understand why some septic shock patients respond better to the drug vasopressin. Researchers planned to compare blood markers, heart ultrasound images, and tissue oxygen levels between responders and non-responders. However, the study was termin…

This study gave healthy adults nose drops containing a harmless bacteria (N. lactamica) to see how the body's immune system responds. The goal is to learn if the immune response is the same whether the bacteria is cleared after 4 days or 14 days. This information will help design…

This study looked at how mechanical ventilation (breathing machines) affects the energy centers (mitochondria) of immune cells in patients with severe lung infections and acute respiratory distress syndrome (ARDS). Researchers aimed to understand why some patients get worse despi…

This study aimed to compare how the immune system responds to two different seasonal flu vaccines given at the same time. Healthy adults aged 18-49 who had not received a flu shot in at least three years were eligible. The study was terminated early and only enrolled 2 participan…

This pilot study tested several low-cost behavioral nudges, like videos and text messages, to encourage HIV retesting among 98 adults at higher risk of HIV in rural Kenya and Uganda. The goal was to see which approaches were acceptable and feasible, so the best ones could be used…

This study tested whether placing a reminder sticker on the charts of adult hospital patients receiving IV fluoroquinolone antibiotics would encourage doctors to switch them to oral pills sooner. The trial involved 168 patients at a single hospital in Thailand. Unfortunately, the…

This study looked at whether virtual coaching helps rural pharmacists better counsel patients who are hesitant about COVID-19 vaccines. Sixteen pharmacies took part, first receiving standard training and then adding one-on-one video coaching. The main goal was to see if coaching …

This study looked at whether people born with cytomegalovirus (CMV) infection who have hearing loss or balance problems also have a condition called endolymphatic hydrops (fluid buildup in the inner ear). Researchers used a special MRI scan with a contrast dye to check for this f…

This study aimed to see how often people with chronic hepatitis C have a blood condition called monoclonal B-cell lymphocytosis (MBL), and whether treating hepatitis C affects MBL. Researchers planned to enroll 29 participants and compare blood samples before and after hepatitis …

This study looked at how extracorporeal photopheresis (ECP) — a treatment that uses light to modify a patient's own blood cells — affects the immune system in people with chronic graft-versus-host disease (cGVHD), a complication after a stem cell transplant. Only 8 people were en…

This study aimed to understand how COVID-19 affects people with cancer, especially those receiving treatment. Researchers planned to measure how many cancer patients had COVID-19 without symptoms and how their immune systems responded. The study was terminated early, so results a…

This study looked at how certain immune cells, called non-conventional T cells, behave in patients with severe pneumonia and acute respiratory distress syndrome (ARDS). Researchers collected blood and airway samples from 258 intensive care unit patients to track these cells over …

This study followed 80 adults who recovered from COVID-19 to check for heart problems. Participants had heart exams and blood tests one month and one year after recovery. The goal was to understand how often and what kind of heart issues occur after COVID-19, so doctors can bette…

This study aimed to check the safety of a rabies immune globulin shot (HyperRAB) in children who were treated after an animal bite. It included 35 kids aged 17 and under across several emergency rooms. The study was stopped early, so results are limited, but the goal was to see i…

This study aimed to measure how well the 2024-2025 Pfizer COVID-19 vaccine prevents symptomatic infection in people visiting CVS MinuteClinics. Researchers planned to compare vaccinated and unvaccinated patients across age groups and variant periods. However, the study was termin…

This study tested a special band called AirGo to monitor breathing patterns in hospitalized COVID-19 patients with respiratory failure. The goal was to see if the band could detect early signs of worsening breathing, helping doctors decide when to use a breathing tube. The study …

This study followed 190 young women to learn how the body handles new HPV infections. Researchers measured virus levels, immune cells, and other factors over time. The goal was to understand why some infections clear quickly while others persist. No treatment was given; this was …

This study used a special MRI technique with a harmless gas called hyperpolarized xenon-129 to take detailed pictures of lung function in people who had a lung transplant. The goal was to see if this scan could detect early signs of chronic lung allograft dysfunction (CLAD), a co…

This study looked at how much physical activity and sitting time people with HIV in New York City get. Participants wore a small device called an accelerometer for a week to track their movement. The goal was to understand how activity levels relate to overall health. The study w…

This study looked at bone density in HIV-positive men to see if antiretroviral drugs cause bone thinning. Researchers compared men starting HIV treatment with those not yet on therapy over two years. The goal was to understand why bone loss is more common in HIV patients.

This early-phase study tested the safety and tolerability of an experimental drug called iCP-NI in 24 healthy adults. Participants received either the drug or a placebo by intravenous infusion. The trial was terminated, so no conclusions about effectiveness can be drawn.

This study observed over 1,700 adults with chronic hepatitis B in the US and Canada to understand how the disease progresses and how treatments are used in everyday medical practice. Researchers collected data from both academic and community clinics to build a real-world picture…

This study looked at how well the COVID-19 vaccine triggers an immune response in people with autoimmune or inflammatory diseases who take immunosuppressants or biologics. Researchers took blood samples before vaccination and at several points after to measure antibodies and T-ce…

This study tracked how the antibiotic ceftazidime-avibactam is used in real hospital settings in China for serious infections like pneumonia and abdominal infections. Researchers planned to enroll 450 patients but the study was terminated early. The goal was to see how often the …

This study tested a new type of MRI that uses inhaled xenon gas to create detailed images of the lungs. The goal was to see if it could detect early signs of chronic rejection in lung transplant recipients. Only 6 adults who had double lung transplants took part, and the study wa…

This study aimed to collect eye scans from people who had COVID-19 to see if the virus caused damage to the retina, the light-sensitive tissue at the back of the eye. Researchers planned to compare severe and mild COVID-19 cases, but the study was stopped early and only enrolled …