COVID-19 antibody drug trial halted early — little data to show

NCT ID NCT05081388

Terminated Disease control Sponsor: Regeneron Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage study tested a new antibody drug (REGN14256) alone or with imdevimab in 25 adults with mild COVID-19 and no risk factors for severe illness. The goal was to check safety and whether the drug could lower virus levels. However, the trial was terminated early, so we have no clear results on how well it worked.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

REGN14256 and imdevimab (antibody drugs)

What this could lead to

If successful, this could provide a treatment option for COVID-19 patients without severe disease risk.

What could go wrong

The trial was terminated early with only 25 participants, so no conclusions can be drawn. Early-phase studies often fail to show benefit.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Coronavinae infectious disease COVID-19

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SARS COV-2

Contacts and locations

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Locations

AGA Clinical Trials

Hialeah, Florida, 33012, United States
Advanced Diagnostics Clinic, River Oaks Hospital and Clinics

Houston, Texas, 77027, United States
Ark Clinical Research

Long Beach, California, 90806, United States
Bio-Medical Research LLC

Miami, Florida, 33184, United States
Carolina Medical Research

Clinton, South Carolina, 29325, United States
Charisma Research and Medical Center

Miami Lakes, Florida, 33014, United States
Chicago Clinical Research Institute

Chicago, Illinois, 60607, United States
Forte Family Practice

Las Vegas, Nevada, 89103, United States
Global Medical Trials

Miami, Florida, 33174, United States
IACT Health

Columbus, Georgia, 31904, United States
NYC H+H / Jacobi Medical Center

The Bronx, New York, 10461, United States
New York Health and Hospitals / Lincoln

The Bronx, New York, 10451, United States
Olive Branch Family Medical Center

Olive Branch, Mississippi, 38654, United States
PNS Clinical Research, LLC

Mission Viejo, California, 92691, United States
PharmaTex Research, LLC

Amarillo, Texas, 79109, United States
Project 4 Research, Inc.

Miami, Florida, 33125, United States
Regeneron Research Site

La Mesa, California, 91941, United States
Regeneron Research Site

Ft. Pierce, Florida, 34982, United States
Regeneron Research Site

Loxahatchee Groves, Florida, 33470, United States
Regeneron Research Site

Winter Park, Florida, 32789, United States
Regeneron Research Site

Ames, Iowa, 50010, United States
Regeneron Research Site

Marrero, Louisiana, 70072, United States
Regeneron Research Site

Wilmington, North Carolina, 28401, United States
Regeneron Research Site

Dayton, Ohio, 45409, United States
Regeneron Research Site

Houston, Texas, 77030, United States
Regeneron Research Site

Houston, Texas, 77093, United States
Triple O Research Institute, P.A.

West Palm Beach, Florida, 33407, United States
Universal Medical and Research Center, LLC

Miami, Florida, 33126, United States