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Polio Survivors' hope dashed: trial of immune treatment halted early

NCT ID NCT02176863

Terminated Disease control Sponsor: Instituto Grifols, S.A. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a blood product called immune globulin (Flebogamma) in 191 people with post-polio syndrome, a condition causing new muscle weakness years after polio. The goal was to see if it could improve walking distance and reduce pain. The trial was terminated early, so we don't have clear answers on whether it works.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
immune globulin (Flebogamma 5% DIF)
What this could lead to
If it worked, this could point toward a treatment to improve walking ability and reduce pain in people with post-polio syndrome.
What could go wrong
The trial was terminated early, so results are limited. It was a mid-stage study, and the treatment may not prove effective or safe for wider use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

postpoliomyelitis syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POST-POLIO SYNDROME

Contacts and locations

Locations

  • Aarhus Universitets Hospital-Neurologisk Forskning

    Aarhus N, 8200, Denmark

  • Academisch Medisch Centrum Amsterdam UMC, Locatie AMC

    Amsterdam, 1105 AZ, Netherlands

  • Azienda Ospedaliera Universitaria Integrata Verona (Ospedale Borgo Roma)

    Verona, 37124, Italy

  • Charité Campus Mitte

    Berlin, 10117, Germany

  • Clinical Research Center Sp. z o.o.

    Poznan, 60-848, Poland

  • Hannover Medical School

    Hanover, 30625, Germany

  • Hospital Universitari Vall d'Hebron

    Barcelona, 08035, Spain

  • Institut Guttman

    Badalona, 08916, Spain

  • Klinik für konservative Orthopädie und des Poliozentrums

    Koblenz, 56073, Germany

  • MedTrials

    Krakow, 31-436, Poland

  • Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226-3596, United States

  • Montreal Neurological Institute Clinical Research Unit, McGill University

    Montreal, Quebec, H3A 2B4, Canada

  • Rigshospitalet

    København Ø, 2100, Denmark

  • SUNY Upstate Medical University

    Syracuse, New York, 13210, United States

  • Samodzielny Publiczny Centralny Szpital Kliniczny

    Warsaw, 02-097, Poland

  • Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie

    Lublin, 20-954, Poland

  • Thomas Jefferson University Hospital

    Philadelphia, Pennsylvania, 19107, United States

  • Thomayerova nemocnice, Klinicko-farmakologická jednotka

    Prague, 4, Czechia

  • Universitätsklinikum Jena

    Jena, 07747, Germany

  • Washington University

    St Louis, Missouri, 63110, United States

  • Westfälische Wilhelms-Universität Münster

    Münster, 48149, Germany

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