Kidney transplant study tests Once-Daily pill to replace Twice-Daily dosing
NCT ID NCT04773392
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether a once-daily extended-release form of tacrolimus (Envarsus XR) combined with azathioprine could work as well as the standard twice-daily tacrolimus plus mycophenolate in preventing kidney transplant rejection. The trial planned to enroll 20 adults receiving a first kidney transplant, but it was terminated early. Because of the small size and early stop, no firm conclusions can be drawn about the safety or effectiveness of the simplified regimen.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- tacrolimus (Envarsus XR and immediate-release forms), azathioprine, mycophenolate mofetil/mycophenolic acid, basiliximab, rabbit anti-thymocyte globulin
- What this could lead to
- If successful, this could simplify post-transplant medication by using a once-daily pill instead of twice-daily, potentially improving convenience and adherence.
- What could go wrong
- The trial was terminated early and enrolled only 20 people, so results are very limited. It is not known if the simplified regimen is as safe or effective as the standard approach.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for KIDNEY TRANSPLANT REJECTION are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Southern California
Los Angeles, California, 90033, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can your gut bacteria change how transplant drugs work?
- Your gut bacteria might predict transplant rejection
- AI may spot hidden kidney transplant rejection
- A drug given to organ donors may help kidneys work faster after transplant
- Which diuretic protects a new kidney best? a Head-to-Head trial puts furosemide and mannitol to the test
- Blood test clues could make antifungal dosing safer for transplant patients