Kidney transplant patients get extra COVID shot in new trial
NCT ID NCT05220397
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This phase 3 trial tested whether a dose of the Janssen COVID-19 vaccine could boost immunity in kidney transplant recipients who had already received two or three mRNA vaccine doses. The study enrolled 468 participants and also looked at reducing immunosuppression medication. However, the trial was terminated early, so the full results are not available.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Janssen Ad26.CoV2.S vaccine
What this could lead to
If successful, this could show that an extra dose of a different COVID-19 vaccine helps protect kidney transplant patients who had low immunity from mRNA vaccines.
What could go wrong
The trial was terminated early, so results are limited. It is also a small, single-center study, and the vaccine may not work as well in people on strong immunosuppressants.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Mayo Clinic
Phoenix, Arizona, 85054, United States
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Mayo Clinic
Jacksonville, Florida, 32224, United States
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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