Egg-Free flu vaccine tested in kids: could it be just as good?
NCT ID NCT05513391
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study compared a newer recombinant flu vaccine (RIV4, also called Supemtek or Flublok Quadrivalent) to the standard egg-based flu vaccine in 366 children aged 3 to 8 years. The goal was to see if the recombinant vaccine produced a similar immune response and was as safe. The trial was terminated early, so the full results are not available.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Recombinant influenza vaccine (RIV4, Supemtek/Flublok Quadrivalent)
What this could lead to
If successful, this could offer a flu vaccine option for young children that is not made with eggs, potentially improving immune response and supply flexibility.
What could go wrong
The trial was terminated early, so results are limited. It was a non-inferiority study, meaning it aimed to show the new vaccine is as good as the existing one, not necessarily better. Early termination may reduce confidence in findings.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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AMR - Newton Site Number : 8400021
Newton, Kansas, 67114, United States
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Alliance for Multispecialty Research Syracuse Site Number : 8400027
Syracuse, Utah, 84075-9645, United States
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Birmingham Pediatric Associates Site Number : 8400023
Birmingham, Alabama, 35205, United States
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California Research Foundation Site Number : 8400003
San Diego, California, 92123-1881, United States
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Coastal Carolina Research Center Site Number : 8400022
North Charleston, South Carolina, 29405, United States
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Coastal Pediatric Research Charleston Site Number : 8400005
Charleston, South Carolina, 29414, United States
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Investigational Site Number : 6160001
Warsaw, 02-647, Poland
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Investigational Site Number : 6160003
Bydgoszcz, 85-796, Poland
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Investigational Site Number : 6160005
Siemianowice Śląskie, Silesian Voivodeship, 41-103, Poland
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Investigational Site Number : 6160006
Tarnów, 33-100, Poland
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Investigational Site Number : 6160007
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-079, Poland
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Investigational Site Number : 6160010
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-048, Poland
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Investigational Site Number : 6160012
Wroclaw, 53-149, Poland
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Investigational Site Number : 7240001
Móstoles, 28938, Spain
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Investigational Site Number : 7240004
Madrid, 28041, Spain
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Investigational Site Number : 7240005
Málaga, 29015, Spain
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Investigational Site Number : 7240007
Seville, 41014, Spain
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Investigational Site Number : 7240014
Madrid, Madrid, Comunidad de, 28046, Spain
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Investigational Site Number : 7240018
Madrid, 28660, Spain
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J. Lewis Research Site Number : 8400017
Salt Lake City, Utah, 84109, United States
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JBR Clinical Research Site Number : 8400001
Salt Lake City, Utah, 84107, United States
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Kentucky Pediatrics / Adult Research Site Number : 8400010
Bardstown, Kentucky, 40004, United States
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Meridian Clinical Research Site Number : 8400006
Binghamton, New York, 13905, United States
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Meridian Clinical Research- Sioux City Site Number : 8400007
Sioux City, Iowa, 51106, United States
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Ohio Pediatric Research Site Number : 8400020
Dayton, Ohio, 45414, United States
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Rainbow Pediatrics Site Number : 8400014
Barnwell, South Carolina, 29812, United States
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The Children's Clinic Of Jonesboro PA Site Number : 8400025
Jonesboro, Arkansas, 72401, United States
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Velocity Clinical Research Lincoln Site Number : 8400013
Lincoln, Nebraska, 68510, United States
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Velocity Clinical Research Omaha Site Number : 8400009
Omaha, Nebraska, 68134, United States
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Velocity Clinical Research Vestal Site Number : 8400016
Vestal, New York, 13850, United States
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Velocity Clinical Research- New Orleans Site Number : 8400012
New Orleans, Louisiana, 70119, United States