Wolbachia-Infected mosquitoes released to fight dengue, zika, and chikungunya

NCT ID NCT06595745

Terminated Prevention Sponsor: Michigan State University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial tested a method to control mosquito-borne diseases like dengue, Zika, and chikungunya by releasing male Aedes aegypti mosquitoes infected with Wolbachia bacteria. These males mate with wild females, causing their eggs to die, which reduces the mosquito population. The study took place in Merida, Mexico, and involved over 15,000 residents. Unfortunately, the trial was terminated early, so its full impact is unknown.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Wolbachia-infected male Aedes aegypti mosquitoes
What this could lead to: If successful, this approach could provide a sustainable, chemical-free way to reduce or eliminate mosquito-borne diseases like dengue, Zika, and chikungunya in affected regions.
What could go wrong: The trial was terminated, so results are incomplete. Effectiveness in real-world settings remains unproven, and scaling up may face logistical or ecological challenges.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chikungunya prevention target dengue disease prevention target Zika virus infectious disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHIKUNGUNYA DENGUE ZIKA

Contacts and locations

Locations

Laboratorio para el Control Biolo´gico de Aedes aegypti (LCB-UADY), Universidad Autónoma de Yucatán

Mérida, Yucatán, 97160, Mexico

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