Chikungunya vaccine shows promise for teens in landmark trial

NCT ID NCT04650399

Completed ⭐️ VACCINE ⭐️ Sponsor: Butantan Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a single-dose chikungunya vaccine (VLA1553) in about 750 teenagers aged 12 to 17. The goal was to see if the vaccine safely produces enough antibodies to protect against the virus. Participants received either the vaccine or a placebo, and their immune responses were tracked for a year.

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Conditions

The condition(s) this trial relates to.

chikungunya prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHIKUNGUNYA

Contacts and locations

Locations

Associação Obras Sociais Irmã Dulce / Centro de Pesquisa Clínica - CPEC

Salvador, Estado de Bahia, 40415-180, Brazil
CECOR - Centro Oncológico de Roraima

Boa Vista, Acre, 69304-015, Brazil
Centro de Estudos do Instituto de Infectologia Emílio Ribas

São Paulo, 01246-900, Brazil
Centro de Pesquisa Clínica da Faculdade de Medicina da Universidade Federal de Mato Grosso do Sul - UFMS

Campo Grande, 79070-900, Brazil
Centro de Pesquisa e Desenvolvimento de Fármacos (CPDF) - Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas

Belo Horizonte, Minas Gerais, 31270-010, Brazil
Centro de Pesquisas Clínicas Universidade Federal Sergipe

Aracaju, Sergipe, 49100-000, Brazil
Faculdade de Medicina de São José do Rio Preto - FAMERP

São José do Rio Preto, São Paulo, 15090-000, Brazil
Fundação de Medicina Tropical Dr. Heitor Vieira Dourado

Manaus, Amazonas, 69040-000, Brazil
Núcleo de Medicina Tropical - Universidade Federal do Ceará

Fortaleza, Ceará, 60020-181, Brazil
Real Hospital Português de Beneficência em Pernambuco

Recife, Pernambuco, 52010-075, Brazil

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