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Chikungunya's lingering curse: joint pain still haunts patients 15 years later

NCT ID NCT04838574

Knowledge-focused Sponsor: Centre Hospitalier Universitaire de la Réunion Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study checks in on 152 people from Reunion Island who had Chikungunya during the 2005-2006 outbreak. Researchers want to classify the types of joint pain and swelling that persist 15 years after infection. Participants undergo a rheumatology exam and questionnaire to see if they meet criteria for specific arthritis conditions. The goal is to better understand the long-term impact of the virus.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could reveal how Chikungunya causes long-term arthritis, guiding future treatments for chronic joint pain after infection.
What could go wrong
This is an observational follow-up, not a treatment trial. It describes what happened, not how to fix it, and results may not apply to other outbreaks or regions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

152 people

The number who actually took part.

Started

Feb 2023

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients previously included in the RHUMATOCHIK study, or diagnosed as Chikungunya-related Rheumatoid Arthritis in the Reunion Island.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients previously included in the RHUMATOCHIK study (N=307), or diagnosed as Chikungunya-related Rheumatoid Arthritis (N=21) after telephonic screening and given their oral consent * Chikungunya infection (positive serology and/or evocative symptoms in the epidemic context) Exclusion Criteria: * Impossible informed consent (cognitive impairment,…). * Lost-to-follow-up patients, refusal to participate. -Pre-existing chronic inflammatory rheumatic disease (prior to CHIKV infection)-

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Conditions

The condition(s) this trial relates to.

chikungunya

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chikungunya

Contacts and locations

Locations

  • CH Ouest Réunion

    Saint-Paul, Reunion

  • CHU La Réunion (Nord)

    Saint-Denis, 97400, Reunion

  • CHU La Réunion (Sud)

    Saint-Pierre, 97448, Reunion

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