Experimental cancer drug trial ends early

NCT ID NCT04272034

Terminated Disease control Sponsor: Incyte Corporation Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage study tested an experimental drug called INCB099318 in people with advanced solid tumors that had stopped responding to standard treatments. The main goal was to check the drug's safety and how the body processes it. The study was terminated early, so results are limited.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

anal carcinoma anus neoplasm basal cell carcinoma cervical cancer cutaneous neuroendocrine carcinoma endometrium neoplasm esophageal squamous cell carcinoma mesothelioma nasopharyngeal carcinoma Neoplasm Metastasis renal cell carcinoma sarcomatoid renal cell carcinoma skin squamous cell carcinoma small cell lung carcinoma squamous cell carcinoma of penis transitional cell carcinoma Uterine Cervical Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMORS ANAL CARCINOMA BASAL CELL CARCINOMA (UNRESECTABLE OR METASTATIC) CERVICAL CANCER CLEAR CELL OVARIAN OR ENDOMETRIAL CARCINOMA CUTANEOUS SQUAMOUS CELL CARCINOMA CYCLIN-DEPENDENT KINASE 12 MUTATED TUMORS DNA POLYMERASE EPSILON MUTATED TUMORS (P286R AND V411L) ESOPHAGEAL SQUAMOUS CELL CARCINOMA MERKEL CELL CARCINOMA MESOTHELIOMA MSI-H/DMMR TUMORS NASOPHARYNGEAL CARCINOMA PD-L1 AMPLIFIED TUMOR (9P24.1) SARCOMATOID RENAL CELL CARCINOMA SMALL CELL LUNG CANCER SQUAMOUS CELL PENILE CARCINOMA UROTHELIAL CARCINOMA, HCC

Contacts and locations

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Locations

Docrates Cancer Center

Helsinki, 00180, Finland
Freeman Hospital Newcastle Upon Tyne Foundation Nhs Trust

Newcastle upon Tyne, NE7 7DN, United Kingdom
Ghent University Hospital

Ghent, 09000, Belgium
Guys and St Thomas Nhs Foundation Trust

London, SE1 9RT, United Kingdom
Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States
Haukeland University Hospital

Bergen, 05051, Norway
Helsinki University Central Hospital

Helsinki, 00029, Finland
Imperial College Healthcare Nhs Trust - Hammersmith Hospital

London, W12 0HS, United Kingdom
Institut Jules Bordet

Brussels, B-1070, Belgium
Karolinska University Hospital Solna

Solna, 17164, Sweden
Oslo University Hospital

Oslo, 00450, Norway
Prisma Health Cancer Institute Faris

Greenville, South Carolina, 29605, United States
Rigshospitalet Uni of Hospital of Copenhagen

Copenhagen, 02100, Denmark
Sahlgrenska University Hospital

Gothenburg, 41345, Sweden
St James University Hospital

Leeds, LS9 7TF, United Kingdom
Tampere University Hospital

Tampere, 33520, Finland
The Royal Marsden Hospital Nhs Trust London

London, SM2 5PT, United Kingdom
Turku University Hospital

Turku, 20520, Finland
Universitair Ziekenhuis Antwerpen (Uza)

Edegem, 02650, Belgium
Universitair Ziekenhuis Brussel

Brussels, 01090, Belgium
Universitaire Ziekenhuis Leuven - Gasthuisberg

Leuven, 03000, Belgium
Uppsala Universitet - Akademiska Sjukhuset

Uppsala, 75185, Sweden
Vanderbilt-Ingram Cancer Center

Nashville, Tennessee, 37232, United States
Western General Hospital

Edinburgh, EH4 2XU, United Kingdom