MRNA shingles vaccine trial ends early – what we know

NCT ID NCT05703607

Terminated ⭐️ VACCINE ⭐️ Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested several experimental mRNA vaccines against shingles in healthy adults aged 50 to 85. The goal was to check safety and immune response compared to the current shingles vaccine, Shingrix. The trial was terminated early, so results are limited, but the data may help develop future shingles vaccines.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: mRNA vaccine against varicella zoster virus
What this could lead to: If successful, this could lead to a new mRNA-based shingles vaccine that is easier to produce and store than current options.
What could go wrong: The trial was terminated early, so we have limited data. It is still in early phases (1/2), meaning safety and effectiveness are not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chickenpox human disease herpes zoster prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HERPES ZOSTER INFECTION HUMAN SHINGLES

Contacts and locations

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Locations

Accellacare - Wilmington

Wilmington, North Carolina, 28401, United States
Acevedo Clinical Research Associates

Miami, Florida, 33142, United States
Associates in Cardiology, PA

Silver Spring, Maryland, 20910, United States
Aventiv Research Inc.

Mesa, Arizona, 85206, United States
C.S. Mott Clinical Research Center (CRC)

Detroit, Michigan, 48201, United States
CTI Clinical Research Center

Cincinnati, Ohio, 45212, United States
Centennial Medical Group

Columbia, Maryland, 21045, United States
Centricity Research Columbus Ohio Multispecialty

Columbus, Ohio, 43213, United States
Clinical Trials of Texas, LLC

San Antonio, Texas, 78229, United States
Clinical Trials of Texas, LLC dba Flourish Research

San Antonio, Texas, 78229, United States
Columbus Cardiovascular Associates, Inc.

Columbus, Ohio, 43213, United States
Diablo Clinical Research, Inc.

Walnut Creek, California, 94598, United States
Dynamed Clinical Research, LP d/b/a DM Clinical Research

Tomball, Texas, 77375, United States
East-West Medical Research Institute

Honolulu, Hawaii, 96814, United States
GW Medical Faculty Associates

Washington D.C., District of Columbia, 20037, United States
GW Vaccine Research Unit

Washington D.C., District of Columbia, 20037, United States
Henry Ford St. John Hospital

Grosse Pointe Woods, Michigan, 48236, United States
IMA Clinical Research

Albuquerque, New Mexico, 87109, United States
IMA Clinical Research San Antonio

San Antonio, Texas, 78229, United States
Icahn School of Medicine at Mount Sinai

New York, New York, 10029, United States
Johnson County Clinical Trials

Lenexa, Kansas, 66219, United States
NYU Langone Health

New York, New York, 10016, United States
Proactive Clinical Research,LLC

Fort Lauderdale, Florida, 33308, United States
Quality Clinical Research

Omaha, Nebraska, 68114, United States
Rochester Clinical Research, LLC

Rochester, New York, 14609, United States
Solaris Clinical Research

Meridian, Idaho, 83646, United States
South Jersey Infectious Disease

Somers Point, New Jersey, 08244, United States
Stanford University Medical Center

Palo Alto, California, 94304, United States
Tisch Hospital

New York, New York, 10016, United States
Tri-City Cardiology

Gilbert, Arizona, 85233, United States
University of Iowa

Iowa City, Iowa, 52242, United States
University of Nevada School of Medicine - Reno

Reno, Nevada, 89557, United States
Velocity Clinical Research, Norfolk

Norfolk, Nebraska, 68701, United States
West Valley Cardiology Services

Meridian, Idaho, 83642, United States
Wilmington Health, PLLC (Cardiologist)

Wilmington, North Carolina, 28401, United States

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