New shingles vaccine Z-1018 takes on shingrix in Head-to-Head trial
NCT ID NCT06569823
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a new shingles vaccine called Z-1018 in about 764 healthy adults aged 50 and older. It compares Z-1018 to the current vaccine, Shingrix, to see if it is safe and triggers a strong immune response. The trial is in early phases (1 and 2), so the main focus is on safety and how well the body responds.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Z-1018 (investigational shingles vaccine)
What this could lead to
If successful, this could lead to a new, potentially more effective or safer shingles vaccine for older adults.
What could go wrong
This is an early phase 1/2 trial, so safety and effectiveness are not yet proven. The new vaccine may not work as well as Shingrix or could have unexpected side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Canopy Clinical Northern Beaches
Brookvale, New South Wales, 2100, Australia
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Canopy Clinical Wollongong
Wollongong, New South Wales, 2500, Australia
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Doherty Clinical Trials Limited
East Melbourne, Victoria, 3002, Australia
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Emeritus Research
Botany, New South Wales, 2019, Australia
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Emeritus Research
Camberwell, Victoria, 3124, Australia
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Innovate Clinical Research
Waitara, New South Wales, 2077, Australia
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Momentum Clinical Research Kapiti
Wellington, 5036, New Zealand
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Momentum Wellington
Wellington, 0621, New Zealand
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New Zealand Clinical Research
Christchurch, 8011, New Zealand
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Optimal Clinical Trials Ltd - Central
Auckland, 1010, New Zealand
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Optimal Clinical Trials Ltd - North
Auckland, 0632, New Zealand
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Paratus Clinical Research Brisbane
Herston, Queensland, 4006, Australia
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Paratus Clinical Research Central Coast
Kanwal, New South Wales, 2259, Australia
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Paratus Clinical Research Western Syndney
Blacktown, New South Wales, 2148, Australia
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Sutherland Shire Clinical Research
Miranda, New South Wales, 2228, Australia
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Veritus Research
Bayswater, Victoria, 3153, Australia