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Bladder cancer trial halted: could trilaciclib have saved bone marrow?

NCT ID NCT04887831

Terminated Disease control Sponsor: G1 Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This phase 2 trial tested whether adding trilaciclib (Cosela) to standard chemotherapy and avelumab could help people with advanced bladder cancer by protecting their bone marrow. The study enrolled 92 adults with untreated, locally advanced or metastatic urothelial carcinoma. Unfortunately, the trial was terminated early, so we don't have complete data on whether trilaciclib improved outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Trilaciclib (Cosela) given with chemotherapy (gemcitabine plus cisplatin or carboplatin) and avelumab (Bavencio) maintenance therapy

What this could lead to

If it worked, trilaciclib might help protect bone marrow during chemotherapy, potentially allowing more effective cancer treatment with fewer side effects.

What could go wrong

This trial was terminated early, so we don't have full results. It's a phase 2 study, meaning it's still early and may not lead to a new standard treatment.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

chemotherapy-induced toxicity stage IVb bladder cancer transitional cell carcinoma urinary bladder carcinoma Urinary Bladder Neoplasms urothelial carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BLADDER CANCER CHEMOTHERAPY INDUCED NEUTROPENIA METASTATIC BLADDER CANCER MYELOSUPPRESSION ADULT UROTHELIAL CARCINOMA

Contacts and locations

Locations

  • ALTHAIA, Xarxa Assistencial Universitiria de Manresa

    Manresa, Barcelona, 08243, Spain

  • Beacon Cancer Center PLLC

    Coeur d'Alene, Idaho, 83814, United States

  • Centre Léon Bérard - Département d'oncologie médicale

    Lyon, 69373, France

  • Florida Cancer Specialists - North

    St. Petersburg, Florida, 33705, United States

  • Florida Cancer Specialists - South

    Fort Myers, Florida, 33901, United States

  • Fundación Instituto Valenciano de Oncología

    Valencia, 46009, Spain

  • H.U. V. de las Nieves

    Granada, 18014, Spain

  • High Technology Hospital MedCenter LTD

    Batumi, Adjara, 6010, Georgia

  • Hopitaux Universitaires de Strasbourg - Service Oncologie et Hématologie

    Strasbourg, Bas-Rhin, 67091, France

  • Hospital Clinic de Barcelona - Servicio de Oncología Médica

    Barcelona, 08036, Spain

  • Hospital Politecnic Universitari La Fe

    Valencia, 46026, Spain

  • Hospital Universitario Lucus Augusti

    Lugo, 27003, Spain

  • Hospital Universitario Puerta de Hierro Majadahonda

    Majadahonda, Madrid, 28222, Spain

  • Hospital Universitario Vall d´Hebron

    Barcelona, 08035, Spain

  • Hospital de la Santa Creu i Sant Pau

    Barcelona, 08041, Spain

  • Hôpital Européen Georges Pompidou - Service d'Oncologie Médicale

    Paris, 75015, France

  • Institut Bergonié - Oncologie Médicale et Pédiatrique

    Bordeaux, Gironde, 33076, France

  • Institut Català d'Oncologia-Hospital Universitari Germans Trias i Pujol

    Badalona, Barcelona, 08916, Spain

  • Institut de Cancérologie de Lorraine

    Vandœuvre-lès-Nancy, 54519, France

  • Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz - Rendeloint

    Szolnok, Jász-Nagykun-Szolnok, H-5000, Hungary

  • LTD "Multiprofile Clinic Consilium Medulla"

    Tbilisi, 186, Georgia

  • Montefiore Medical Center

    The Bronx, New York, 10461, United States

  • National Center of Urology Named after Laur Managadze

    Tbilisi, 0144, Georgia

  • New York Oncology Hematology, P.C.

    Albany, New York, 12206, United States

  • Northwest Cancer Specialists, P.C.

    Tigard, Oregon, 46241, United States

  • Országos Onkológiai Intézet

    Budapest, 1122, Hungary

  • Rocky Mountain Cancer Centers

    Littleton, Colorado, 80120, United States

  • Tennessee Oncology, PLLC

    Nashville, Tennessee, 37203, United States

  • The Harry and Jeanette Weinberg Cancer Institute

    Baltimore, Maryland, 21237, United States

  • The Oncology Institute of Hope and Innovation

    Whittier, California, 90603, United States

  • University of North Carolina at Chapel Hill

    Chapel Hill, North Carolina, 27599, United States

  • Uzsoki Utcai Kórház

    Budapest, H-1145, Hungary

  • Valkyrie Clinical Trial

    Los Angeles, California, 90067, United States

  • Woodlands Medical Specialists

    Pensacola, Florida, 32503, United States