Could a cheap arthritis drug replace harmful steroids for transplant patients?

NCT ID NCT04932564

First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 29 times

Summary

This study tested leflunomide, a drug used for rheumatoid arthritis, as a first treatment for musculoskeletal graft-versus-host disease (GVHD) — a condition where donor cells attack a patient's joints and muscles after a stem cell transplant. The goal was to see if leflunomide could control the disease with fewer side effects than standard steroid therapy. Only one person enrolled before the study was stopped early.

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Contacts and locations

Locations

  • Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer

    Navi Mumbai, Maharashtra, 410210, India

Conditions

Explore the condition pages connected to this study.