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Pediatric GVHD drug combo trial ends early after enrolling just 2 kids

NCT ID NCT03721965

Terminated Disease control Sponsor: Incyte Corporation Source: ClinicalTrials.gov ↗

First seen Nov 05, 2025 · Last updated May 13, 2026 · Updated 23 times

Summary

This study tested a drug called itacitinib combined with steroids to treat acute graft-versus-host disease (aGVHD) in children. aGVHD is a serious complication after a stem cell transplant where donor cells attack the child's body. The trial was stopped early after only 2 participants enrolled, so we have very limited information on how well the treatment works.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • AOU Citta della Salute e della Scienza di Torino - Ospedale Regina Margherita

    Torino, 10126, Italy

  • Azienda Ospedaliero Unversitatia Policlinico - Vittorio Emanuele - Presido Ospedaliero G. Rodolico

    Catania, 95123, Italy

  • Birmingham Childrens Hospital

    Birmingham, B4 6NH, United Kingdom

  • Bristol Royal Hospital for Children

    Bristol, BS2 8BJ, United Kingdom

  • CHRU Nancy

    Vandœuvre-lès-Nancy, 54500, France

  • CHU Nancy

    Vandœuvre-lès-Nancy, 54500, France

  • CHU de Grenoble

    Grenoble, 38043, France

  • CHU de Grenoble

    Grenoble, 38403, France

  • Central Manchester University Hospital - Royal Manchester Children's Hospital

    Manchester, M13 9WL, United Kingdom

  • Centre Hospitalier Universitaire de Rennes

    Rennes, Cedex 2, 35203, France

  • Children's Hospital Colorado - Center for Cancer and Blood Disorders

    Aurora, Colorado, 80045, United States

  • Children's Hospital of Philadelphia - Center for Childhood Cancer Research

    Philadelphia, Pennsylvania, 19104, United States

  • Childrens Hospital of Orange County

    Orange, California, 92868, United States

  • City of Hope National Medical Center

    Duarte, California, 91010, United States

  • Doernbecher Children's Hospital - Division of Pediatric Hematology

    Portland, Oregon, 97239, United States

  • Duke University Medical Center

    Durham, North Carolina, 27710, United States

  • Fondazione MBBM

    Monza, 20900, Italy

  • Fred Hutchinson Cancer Research Center

    Seattle, Washington, 98109-1024, United States

  • Great Ormond Street Hospital for Children

    London, WC1N 3JH, United Kingdom

  • Hopitaux Universitaires De Strasbourg

    Strasbourg, Cedex, 67098, France

  • Hopitaux Universitaires De Strasbourg

    Strasbourg, 67098, France

  • Hospital Clinico de Santiago de Compostela

    Santiago de Compostela, 15706, Spain

  • Hospital Universitari i Politecnic La Fe

    Valencia, 46026, Spain

  • Hospital Vall D Hebron

    Barcelona, 08035, Spain

  • Leeds Teaching Hospitals NHS Trust

    Leeds, LS13EX, United Kingdom

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Nemours/A.I. duPont Hospital for Children

    Wilmington, Delaware, 19803, United States

  • Nicklaus Children's Hospital

    Miami, Florida, 33155, United States

  • Ospedale Pediatrico Bambino Gesu

    Roma, 00165, Italy

  • Policlinico S. Orsola-Malpighi

    Bologna, 40138, Italy

  • Robert Debre Hospital

    Paris, 75019, France

  • Royal Marsden Hospital - Surrey

    Surrey Quays, SM2 5PT, United Kingdom

  • Sarah Cannon Research Institute, LLC

    Nashville, Tennessee, 37203, United States

  • Universitaetsklinikum Aachen, AoeR

    Aachen, 52074, Germany

  • Universitatsklinikum Jena, Klinik fur Kinder und Jugendmedizin

    Jena, 07747, Germany

  • University Hospitals Cleveland Medical Center - Rainbow Babies and Children's Hospital

    Cleveland, Ohio, 44106, United States

  • University of Minnesota Medical Center

    Minneapolis, Minnesota, 55454, United States

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232-6868, United States

Conditions

Explore the condition pages connected to this study.

ACUTE GRAFT-VERSUS-HOST DISEASE