Xenon gas MRI could spot lung transplant rejection early

NCT ID NCT05550662

Terminated Knowledge-focused Sponsor: The Hospital for Sick Children Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tested a new type of MRI that uses inhaled xenon gas to create detailed images of the lungs. The goal was to see if it could detect early signs of chronic rejection in lung transplant recipients. Only 6 adults who had double lung transplants took part, and the study was stopped early. The approach is still experimental.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Hyperpolarized xenon gas
What this could lead to: If successful, this imaging method could help doctors spot early signs of lung transplant rejection without invasive biopsies.
What could go wrong: This was a very small, early feasibility study with only 6 participants and was terminated early, so results are limited and may not apply broadly.

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Conditions

The condition(s) this trial relates to.

bronchiolitis obliterans syndrome transplant rejection transplant-related bronchiolitis obliterans

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUNG TRANSPLANT REJECTION

Contacts and locations

Locations

Hospital for Sick Chilldren

Toronto, Ontario, M5G 1X8, Canada
The Hospital for Sick Children

Toronto, Ontario, M5G 1X8, Canada

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