COVID-19 drug trial halted early: what happened with ensovibep?
NCT ID NCT04828161
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a single dose of ensovibep, a lab-made protein, in 407 adults with mild COVID-19 symptoms. The goal was to see if it could lower the amount of virus in the body and reduce hospitalizations. The trial was stopped early, so we don't have complete answers on how well it works.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ensovibep (a lab-made protein designed to block the coronavirus)
What this could lead to
If it worked, ensovibep could have provided a new treatment option to reduce hospitalizations and speed recovery for people with mild-to-moderate COVID-19.
What could go wrong
The trial was terminated early, so we don't have full results on whether it works. It was also tested in a specific group of symptomatic adults, so findings may not apply to everyone.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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1960 Family Practice, PA
Houston, Texas, 77090, United States
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AdventHealth Tampa
Tampa, Florida, 33613, United States
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All India Institute of Medical Sciences - Nagpur
Nagpur, Maharashtra, 441108, India
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Ascada Research
Fullerton, California, 92835, United States
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BAPS Pramukhswami Hospital
Surat, Gujarat, 395009, India
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Benchmark Southern California
Colton, California, 92324, United States
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Bio-Medical Research, LLC
Miami, Florida, 33184, United States
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Boward Infectious Disease and Primary Care
Margate, Florida, 33063, United States
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Centennial Medical Group - Research Department
Elkridge, Maryland, 21075, United States
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Clinical Research of Rock Hill
Rock Hill, South Carolina, 29732, United States
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Clinresco Centres (Pty) Ltd
Kempton Park, 1619, South Africa
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DJW Navorsing
Krugersdorp, 1739, South Africa
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Debreceni Egyetem
Debrecen, 4031, Hungary
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Dr JM Engelbrecht Trial Site
Somerset West, Western Cape, 7130, South Africa
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Durgabai Deshmukh Hospital & Research Centre
Vidyānagar, Hyderabad, 500044, India
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Enhancing Care Foundation
Durban, 4052, South Africa
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Epic Medical Research
Red Oak, Texas, 75154, United States
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FARMOVS (Pty) Ltd
Bloemfontein, Free State, 9301, South Africa
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Fairway Medical Clinic
Houston, Texas, 77087, United States
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Family Practice Center
McAllen, Texas, 78501, United States
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Future Innovative Treatments
Colorado Springs, Colorado, 80907, United States
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George Provincial Hospital
George, Western Cape, 6529, South Africa
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Government Medical College
Aurangabad, Maharashtra, 431001, India
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Government Medical College and Hospital
Nagpur, Maharashtra, 440003, India
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Grant Medical College & Sir J. J. Group of Hospitals
Mumbai, Maharashtra, 400008, India
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Great Lakes Clinical Trials
Chicago, Illinois, 60640, United States
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Gwinnett Research Institute
Buford, Georgia, 30519, United States
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IACT Health
Columbus, Georgia, 31904, United States
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Jasper Summit Research, LLC
Jasper, Alabama, 35501, United States
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Jefferson City Medical Group
Jefferson City, Missouri, 65109, United States
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Jongaie Research
Pretoria, 183, South Africa
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King George Hospital
Visakhapatnam, Andhra Pradesh, 530002, India
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Life Spring Research Foundation
Miami, Florida, 33155, United States
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Monroe Biomedical Research
Monroe, North Carolina, 28112, United States
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Pacific Neuropsychiatric Specialists
Mission Viejo, California, 92691, United States
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Palm Beach Research Center
West Palm Beach, Florida, 33409, United States
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Panax Clinical Research, LLC
Miami Lakes, Florida, 33014, United States
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Providence Family Medical Center
Redondo Beach, California, 90277, United States
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Sandton Medical Research Centre
Sandton, Gauteng, 2196, South Africa
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Shetty's Hospital
Bengaluru, Karnataka, 560068, India
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St. Theresa's Hospital
Hyderabad, Telangana, 500018, India
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Suncoast Research Group, LLC
Miami, Florida, 33135, United States
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UMC Utrecht
Utrecht, 3584 CW, Netherlands
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VHS-Infectious Disease Medical Centre
Chennai, Tamil Nadu, 600113, India
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VitaLink Research
Greenville, South Carolina, 29615, United States
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Wilmington Health
Wilmington, North Carolina, 28412, United States
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Wits Clinical Research
Soweto, 2013, South Africa
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Zion Urgent Care Clinic
Katy, Texas, 77494, United States