New inhaled therapy for tough fungus infections falls short in trial

NCT ID NCT05238116

Terminated Disease control Sponsor: Pulmocide Ltd Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 25 times

Summary

This study tested whether adding an inhaled antifungal drug (PC945) to standard treatment could help people with a serious lung fungus infection that wasn't getting better. The trial was stopped early, so we don't have clear proof it works. About 85 adults with proven or probable invasive pulmonary aspergillosis took part.

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Contacts and locations

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Locations

Clinical R Site

Los Angeles, California, 90095, United States
Clinical Research Site

La Jolla, California, 92037, United States
Clinical Research Site

Los Angeles, California, 90048, United States
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Sacramento, California, 95817, United States
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Jacksonville, Florida, 32224, United States
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Baltimore, Maryland, 21287, United States
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Ann Arbor, Michigan, 48109, United States
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Minneapolis, Minnesota, 55455, United States
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St Louis, Missouri, 63110, United States
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The Bronx, New York, 10467, United States
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Philadelphia, Pennsylvania, 19014, United States
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Pittsburgh, Pennsylvania, 15213, United States
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Madison, Wisconsin, 53792, United States
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Caba, Buenos Aires, C1199ABB, Argentina
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La Plata, Buenos Aires, B1900, Argentina
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Caba, Buenos Aries, C1118AAT, Argentina
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Rosario, Santa Fe Province, S2000CVB, Argentina
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Mendoza, M5500, Argentina
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Melbourne, Victoria, 3004, Australia
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Parkville, Victoria, 3050, Australia
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Graz, Styria, 8036, Austria
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Vienna, 1090, Austria
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Brussels, B-1070, Belgium
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Brussels, B-1200, Belgium
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Leuven, B-3000, Belgium
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Curitiba, Paraná, 80060-900, Brazil
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Curitiba, Paraná, 81520060, Brazil
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Passo Fundo, Rio Grande do Sul, 99010260, Brazil
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Porto Alegre, Rio Grande do Sul, 90035903, Brazil
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Santa Maria, Rio Grande do Sul, 97105900, Brazil
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Jaú, São Paulo, 17210-080, Brazil
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Santos, São Paulo, 11075101, Brazil
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Hamilton, Ontario, L8V 1C3, Canada
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Toronto, Ontario, M5G 2C4, Canada
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Toronto, Ontario, M6G2N2, Canada
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Valparaíso, 2570017, Chile
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Montería, Departamento de Córdoba, 230002, Colombia
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Cali, Valle del Cauca Department, 760032, Colombia
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Paris, 75015, France
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Strasbourg, 67091, France
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Würzburg, Bavaria, 97080, Germany
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Frankfurt am Main, Hesse, 60590, Germany
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Athens, 11527, Greece
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Thessaloniki, 57010, Greece
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Bengaluru, Karnataka, 560034, India
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Hyderabad, Telangana, 500082, India
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New Delhi, 110017, India
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Haifa, 3109601, Israel
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Ramat Gan, 5266202, Israel
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Brescia, Lombardy, 25123, Italy
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Monza, 20900, Italy
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Naples, 80131, Italy
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Rome, 00168, Italy
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Siena, 53100, Italy
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Daejeon, 35015, South Korea
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Incheon, 21565, South Korea
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Seoul, 02841, South Korea
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Seoul, 06273, South Korea
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Seoul, 06351, South Korea
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Seoul, 06591, South Korea
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Córdoba, Andalusia, 14004, Spain
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Barcelona, Catalonia, 08035, Spain
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Barcelona, Catalonia, 08036, Spain
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Majadahonda, Madrid, 28222, Spain
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Granada, 18014, Spain
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Valencia, 46026, Spain
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Tapei City, Tapai, 100225, Taiwan
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Kaohsiung City, 807377, Taiwan
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New Taipei City, 220, Taiwan
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New Taipei City, 23561, Taiwan
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Khlong Luang, Changwat Pathum Thani, 12120, Thailand
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Bangkok, 10400, Thailand
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Bangkok, 10700, Thailand
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Khon Kaen, 40002, Thailand
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Harefield, Middlesex, UB9 6JH, United Kingdom
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London, SE5 9RS, United Kingdom
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London, SW17 0QT, United Kingdom
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London, W12 0HS, United Kingdom
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Manchester, M23 9LT, United Kingdom
Clinical Research Site 1

Houston, Texas, 77030, United States
Clinical Research Site 1

Pune, Maharashtra, 411004, India
Clinical Research Site 2

Houston, Texas, 77030, United States
Clinical Research Site 2

Pune, Maharashtra, 411004, India

Conditions

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REFRACTORY IPA