Promising fungal infection treatment study halted early

NCT ID NCT05238116

Terminated Disease control Sponsor: Pulmocide Ltd Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding an inhaled medication (PC945) to standard antifungal drugs could help people with a severe, hard-to-treat lung fungal infection called invasive pulmonary aspergillosis. The trial aimed to see if the combination improved survival and response by day 84. Unfortunately, the study was stopped early, so we have limited information on its effectiveness.

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Conditions

The condition(s) this trial relates to.

invasive aspergillosis Invasive Pulmonary Aspergillosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

REFRACTORY IPA

Contacts and locations

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Locations

Clinical R Site

Los Angeles, California, 90095, United States
Clinical Research Site

La Jolla, California, 92037, United States
Clinical Research Site

Los Angeles, California, 90048, United States
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Sacramento, California, 95817, United States
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Jacksonville, Florida, 32224, United States
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Baltimore, Maryland, 21287, United States
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Ann Arbor, Michigan, 48109, United States
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Minneapolis, Minnesota, 55455, United States
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St Louis, Missouri, 63110, United States
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The Bronx, New York, 10467, United States
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Philadelphia, Pennsylvania, 19014, United States
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Pittsburgh, Pennsylvania, 15213, United States
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Madison, Wisconsin, 53792, United States
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Caba, Buenos Aires, C1199ABB, Argentina
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La Plata, Buenos Aires, B1900, Argentina
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Caba, Buenos Aries, C1118AAT, Argentina
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Rosario, Santa Fe Province, S2000CVB, Argentina
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Mendoza, M5500, Argentina
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Melbourne, Victoria, 3004, Australia
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Parkville, Victoria, 3050, Australia
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Graz, Styria, 8036, Austria
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Vienna, 1090, Austria
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Brussels, B-1070, Belgium
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Brussels, B-1200, Belgium
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Leuven, B-3000, Belgium
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Curitiba, Paraná, 80060-900, Brazil
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Curitiba, Paraná, 81520060, Brazil
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Passo Fundo, Rio Grande do Sul, 99010260, Brazil
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Porto Alegre, Rio Grande do Sul, 90035903, Brazil
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Santa Maria, Rio Grande do Sul, 97105900, Brazil
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Jaú, São Paulo, 17210-080, Brazil
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Santos, São Paulo, 11075101, Brazil
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Hamilton, Ontario, L8V 1C3, Canada
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Toronto, Ontario, M5G 2C4, Canada
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Toronto, Ontario, M6G2N2, Canada
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Valparaíso, 2570017, Chile
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Montería, Departamento de Córdoba, 230002, Colombia
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Cali, Valle del Cauca Department, 760032, Colombia
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Paris, 75015, France
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Strasbourg, 67091, France
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Würzburg, Bavaria, 97080, Germany
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Frankfurt am Main, Hesse, 60590, Germany
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Athens, 11527, Greece
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Thessaloniki, 57010, Greece
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Bengaluru, Karnataka, 560034, India
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Hyderabad, Telangana, 500082, India
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New Delhi, 110017, India
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Haifa, 3109601, Israel
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Ramat Gan, 5266202, Israel
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Brescia, Lombardy, 25123, Italy
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Monza, 20900, Italy
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Naples, 80131, Italy
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Rome, 00168, Italy
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Siena, 53100, Italy
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Daejeon, 35015, South Korea
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Incheon, 21565, South Korea
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Seoul, 02841, South Korea
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Seoul, 06273, South Korea
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Seoul, 06351, South Korea
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Seoul, 06591, South Korea
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Córdoba, Andalusia, 14004, Spain
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Barcelona, Catalonia, 08035, Spain
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Barcelona, Catalonia, 08036, Spain
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Majadahonda, Madrid, 28222, Spain
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Granada, 18014, Spain
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Valencia, 46026, Spain
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Tapei City, Tapai, 100225, Taiwan
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Kaohsiung City, 807377, Taiwan
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New Taipei City, 220, Taiwan
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New Taipei City, 23561, Taiwan
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Khlong Luang, Changwat Pathum Thani, 12120, Thailand
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Bangkok, 10400, Thailand
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Bangkok, 10700, Thailand
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Khon Kaen, 40002, Thailand
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Harefield, Middlesex, UB9 6JH, United Kingdom
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London, SE5 9RS, United Kingdom
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London, SW17 0QT, United Kingdom
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London, W12 0HS, United Kingdom
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Manchester, M23 9LT, United Kingdom
Clinical Research Site 1

Houston, Texas, 77030, United States
Clinical Research Site 1

Pune, Maharashtra, 411004, India
Clinical Research Site 2

Houston, Texas, 77030, United States
Clinical Research Site 2

Pune, Maharashtra, 411004, India