Experimental CAR T-Cell therapy targets rare B-Cell cancers
NCT ID NCT05537766
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 study tested a treatment called brexucabtagene autoleucel, a CAR T-cell therapy made from a patient's own immune cells, for four rare B-cell cancers: Waldenstrom macroglobulinemia, Richter transformation, Burkitt lymphoma, and hairy cell leukemia. The trial enrolled 19 adults whose cancers had returned or stopped responding to standard treatments. The study was terminated early, so the full effectiveness and safety are not yet clear.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- brexucabtagene autoleucel (a CAR T-cell therapy made from the patient's own immune cells)
- What this could lead to
- If successful, this could offer a new treatment option for people with rare B-cell cancers that have not responded to standard therapy.
- What could go wrong
- The trial was terminated early with only 19 participants, so results are limited. CAR T-cell therapy can cause serious side effects like cytokine release syndrome and nervous system problems.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for RELAPSED/REFRACTORY BURKITT LYMPHOMA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
ASST Grande Ospedale Metropolitano Niguarda
Milan, 20162, Italy
-
Azienda Ospedale di Perugia - Ospedale S. Maria della Misericordia
Perugia, 06132, Italy
-
Centre hospitalier de Toulouse - Hematology department
Toulouse, 31059, France
-
City of Hope (City of Hope National Medical Center)
Duarte, California, 91010, United States
-
Colorado Blood Cancer Institute
Denver, Colorado, 80218, United States
-
Georgetown University Medical Centre
Washington D.C., District of Columbia, 20037, United States
-
Hackensack University Medical Center
Hackensack, New Jersey, 07601, United States
-
Hopital de la Pitie Salpetriere
Paris, 75013, France
-
Hospital Clinic de Barcelona
Barcelona, 08036, Spain
-
Hospital Universitario Virgen del Rocio
Seville, 41013, Spain
-
Hospital Universitario de Salamanca
Salamanca, 37007, Spain
-
IRCCS Azienda Ospedaliero - Universitaria di Bologna
Bologna, 40138, Italy
-
Istituto Oncologico Della Svizzera Italiana (IOSI)
Bellinzona, 6500, Switzerland
-
MD Anderson Cancer Center
Houston, Texas, 77030, United States
-
Medical University of Vienna, Department of Internal Medicine I, Div. of Hematology
Vienna, 01090, Austria
-
Radboud University Nijmegen Medical Centre
Nijmegen, 6525 GA, Netherlands
-
Stanford Cancer Institute
Stanford, California, 94305, United States
-
Tennessee Oncology, PLLC
Nashville, Tennessee, 37203, United States
-
The Ohio State University Wexner Medical Center - James Cancer HospitalS
Columbus, Ohio, 43210, United States
-
UPMC Hillman Cancer Center
Pittsburgh, Pennsylvania, 15232, United States
-
Universitatsklinikum Heidelberg
Heidelberg, 69120, Germany
-
Universitatsklinikum Koln
Cologne, 50937, Germany
-
Universitatsklinikum Ulm
Ulm, 89081, Germany
-
University of Iowa
Iowa City, Iowa, 52242, United States
-
Vanderbilt University
Nashville, Tennessee, 37232, United States
-
Washington University School of Medicine
St Louis, Missouri, 63110, United States