Nasal spray could be new weapon against COVID-19
NCT ID NCT05109611
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether a nitric oxide nasal spray could prevent COVID-19 in people at risk of exposure. About 1,400 adults used the spray or a placebo for 28 days. The trial was terminated early, so final results are not available.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
nitric oxide nasal spray
What this could lead to
If it worked, this could provide a simple, over-the-counter nasal spray to help prevent COVID-19 infection.
What could go wrong
The study was terminated early, so we don't have clear evidence it works. It was also tested against earlier virus strains, so results may not apply to newer variants.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Colombo North Teaching Hospital,
Ragama, Sri Lanka
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Karapitiya teaching Hospital,
Galle, Sri Lanka
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Medical Trust Clinics , Inc
Oshawa, Ontario, L1G 4T3, Canada
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National Institute of Infectious Diseases Hospital, Angoda
Angoda, Sri Lanka
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Peradeniya Teaching Hospital,
Peradeniya, Sri Lanka
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Puttalam Base Hospital,
Puttalam, Sri Lanka