Nasal spray could be new weapon against COVID-19

NCT ID NCT05109611

Terminated Prevention Sponsor: Sanotize Research and Development corp. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a nitric oxide nasal spray could prevent COVID-19 in people at risk of exposure. About 1,400 adults used the spray or a placebo for 28 days. The trial was terminated early, so final results are not available.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: nitric oxide nasal spray
What this could lead to: If it worked, this could provide a simple, over-the-counter nasal spray to help prevent COVID-19 infection.
What could go wrong: The study was terminated early, so we don't have clear evidence it works. It was also tested against earlier virus strains, so results may not apply to newer variants.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

COVID-19 prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SARS-COV-2 INFECTION

Contacts and locations

Locations

Colombo North Teaching Hospital,

Ragama, Sri Lanka
Karapitiya teaching Hospital,

Galle, Sri Lanka
Medical Trust Clinics , Inc

Oshawa, Ontario, L1G 4T3, Canada
National Institute of Infectious Diseases Hospital, Angoda

Angoda, Sri Lanka
Peradeniya Teaching Hospital,

Peradeniya, Sri Lanka
Puttalam Base Hospital,

Puttalam, Sri Lanka

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