Sanofi's COVID vaccine trial ends early – what we know

NCT ID NCT04904549

Terminated ⭐️ VACCINE ⭐️ Sponsor: Sanofi Pasteur, a Sanofi Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 study tested two Sanofi COVID-19 vaccines (one targeting the original virus, another targeting two variants) in about 24,000 adults. The goal was to see if they could prevent COVID-19 safely. The trial was terminated early, so final results are limited, but the data may still help improve future vaccines.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

SARS-CoV-2 adjuvanted recombinant protein vaccine (monovalent and bivalent)

What this could lead to

If successful, this could provide a new option for COVID-19 vaccination, potentially offering protection against multiple variants.

What could go wrong

The trial was terminated early, so data may be incomplete. As a Phase 3 study, it was large but results may not apply to newer variants.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

COVID-19 prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID-19

Contacts and locations

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Locations

AES - DRS - Simon Williamson Clinic, PC - Birmingham- Site Number : 8400004

Birmingham, Alabama, 35211, United States
AES Austin- Site Number : 8400003

Austin, Texas, 78744, United States
AES Salt Lake City- Site Number : 8400016

Murray, Utah, 84123, United States
AES St. Petersburg- Site Number : 8400017

Pinellas Park, Florida, 33781, United States
American Indian Clinical Trials Research Network Site Number : 8400025

Rapid City, South Dakota, 57701, United States
Coastal Carolina Research Center - N Charleston- Site Number : 8400022

North Charleston, South Carolina, 29405, United States
Investigational Site Number : 1700001

Bogotá, 111611, Colombia
Investigational Site Number : 1700002

Barranquilla, 080020, Colombia
Investigational Site Number : 1700003

Soledad, 083001, Colombia
Investigational Site Number : 1700004

Floridablanca, 681004, Colombia
Investigational Site Number : 1700005

Cali, 76001, Colombia
Investigational Site Number : 1700006

Chía, 0000, Colombia
Investigational Site Number : 1700007

Girardot, 252431, Colombia
Investigational Site Number : 1700008

Barranquilla, 080020, Colombia
Investigational Site Number : 1700009

Meta, 0000, Colombia
Investigational Site Number : 1700010

Aguazul, 856018, Colombia
Investigational Site Number : 1700015

Quindío, 630001, Colombia
Investigational Site Number : 2880001

Navrongo, 114, Ghana
Investigational Site Number : 2880002

Kintampo, P. O. Box 200, Ghana
Investigational Site Number : 2880003

Kumasi, 00000, Ghana
Investigational Site Number : 3400001

Municipio Del Distrito Central, 11101, Honduras
Investigational Site Number : 3400002

San Pedro Sula, 21104, Honduras
Investigational Site Number : 3560001

Jaipur, 302039, India
Investigational Site Number : 3560002

Ambawadi, 380015, India
Investigational Site Number : 3560003

Punjagutta, 500082, India
Investigational Site Number : 3560004

Patna, 801507, India
Investigational Site Number : 3560005

Kanpur, 208002, India
Investigational Site Number : 3560006

Tamilnadu, 603203, India
Investigational Site Number : 3560007

Belagavi, 590002, India
Investigational Site Number : 3560009

Nagpur, 440001, India
Investigational Site Number : 3560010

Ajmer, 305001, India
Investigational Site Number : 3560011

Odisha, 751003, India
Investigational Site Number : 3920001

Kyobashi Chuo-ku, Tokyo, 104-0031, Japan
Investigational Site Number : 3920002

Ohta-ku, Tokyo, 143-0015, Japan
Investigational Site Number : 3920003

Kouenji minami,Suginami-ku, Tokyo, 166-0003, Japan
Investigational Site Number : 3920004

Haramachi,Shinjuku-ku, Tokyo, 162-0053, Japan
Investigational Site Number : 3920005

Chiyoda-ku,, Tokyo, 101-0041, Japan
Investigational Site Number : 4040001

Nairobi, 00100GPO, Kenya
Investigational Site Number : 4040002

Kisumu, 40100, Kenya
Investigational Site Number : 4040003

Kisumu, 40100, Kenya
Investigational Site Number : 4040004

Kericho, 00200, Kenya
Investigational Site Number : 4040006

Eldoret, 30100, Kenya
Investigational Site Number : 4040007

Nairobi, 00100, Kenya
Investigational Site Number : 4040008

Mombasa, 80107 Ganjoni, Kenya
Investigational Site Number : 4040009

Thika, 00202 Kiambu, Kenya
Investigational Site Number : 4040011

Butere, 50101, Kenya
Investigational Site Number : 4040012

Kisumu, 40123 Kisumu, Kenya
Investigational Site Number : 4840002

Veracruz, 91910, Mexico
Investigational Site Number : 4840003

Guadalajara, Jalisco, 44280, Mexico
Investigational Site Number : 4840004

Acapulco de Juárez, Guerrero, 39670, Mexico
Investigational Site Number : 4840005

León, Guanajuato, 37000, Mexico
Investigational Site Number : 4840006

Temixco, 62587, Mexico
Investigational Site Number : 4840008

Cuernavaca, Morelos, 62290, Mexico
Investigational Site Number : 4840009

Mexico City, Mexico City, 04530, Mexico
Investigational Site Number : 5240001

Nepalgunj, 21900, Nepal
Investigational Site Number : 5240002

Dhulikhel, 45200, Nepal
Investigational Site Number : 5240003

Kathmandu, 44600, Nepal
Investigational Site Number : 8000001

Kampala, 0, Uganda
Investigational Site Number : 8000002

Entebbe, 0, Uganda
Investigational Site Number : 8000003

Kampala, 42 Nakasero Road, Uganda
Investigational Site Number : 8000004

Kampala, Plot 101, Lubowa, Uganda
Investigational Site Number : 8000005

Entebbe, 0, Uganda
Investigational Site Number : 8000007

Kampala, 23491, Uganda
Investigational Site Number : 8000013

Kampala, 10101, Uganda
Investigational Site Number : 8000014

Lira, 10101, Uganda
Investigational Site Number : 8040001

Kyiv, 03037, Ukraine
Investigational Site Number : 8040002

Kiev, 04210, Ukraine
Investigational Site Number : 8040003

Kyiv, 02002, Ukraine
Investigational Site Number : 8040004

Kyiv, 01023, Ukraine
Optimal Research Alabama- Site Number : 8400019

Huntsville, Alabama, 35802, United States
Optimal Research, LLC-Melbourne- Site Number : 8400002

Melbourne, Florida, 32934, United States
Peninsula Research Associates, Inc.- Site Number : 8400021

Rolling Hills Estates, California, 90274, United States
Rochester Clinical Research, Inc.- Site Number : 8400023

Rochester, New York, 14609, United States
Synexus Akron- Site Number : 8400009

Akron, Ohio, 44311, United States
Synexus Clinical Research Anderson- Site Number : 8400007

Anderson, South Carolina, 29621, United States
Synexus Clinical Research Chicago- Site Number : 8400012

Chicago, Illinois, 60602, United States
Synexus Clinical Research Evansville- Site Number : 8400008

Evansville, Indiana, 47714, United States
Synexus Clinical Research US, Inc. - Atlanta- Site Number : 8400005

Atlanta, Georgia, 30328, United States
Synexus Clinical Research US, Inc. - Cincinnati- Site Number : 8400010

Cincinnati, Ohio, 45236, United States
Synexus Clinical Research US, Inc. - Henderson- Site Number : 8400018

Henderson, Nevada, 89052, United States
Synexus Clinical Research US, Inc. - Orlando- Site Number : 8400020

Orlando, Florida, 32806, United States
Synexus Clinical Research US, Inc. - San Antonio- Site Number : 8400015

San Antonio, Texas, 78229, United States
Synexus Clinical Research US, Inc. Site Number : 8400013

Centennial, Colorado, 80112, United States
Synexus Dallas- Site Number : 8400014

Dallas, Texas, 75231, United States
Synexus St. Louis- Site Number : 8400006

St Louis, Missouri, 63141, United States
Synexus US Columbus- Site Number : 8400011

Columbus, Ohio, 43212, United States