Plasma from recovered patients tested against COVID-19 – trial ends early
NCT ID NCT04516811
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether giving plasma (the liquid part of blood) from people who recovered from COVID-19 could help hospitalized patients with moderate to severe COVID-19. The plasma contains antibodies that might fight the virus. The trial planned to enroll many patients but was stopped early after including 102 adults. Participants received either the plasma or a placebo (salt water) along with standard care. The main goal was to see if more patients improved within 28 days.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
COVID-19 convalescent plasma (antibodies from recovered patients)
What this could lead to
If it worked, this could provide a treatment option for hospitalized COVID-19 patients using donated antibodies.
What could go wrong
The trial was terminated early with only 102 participants, so results are limited. Convalescent plasma carries risks like allergic reactions or lung injury.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Mitchells Plain Hospital
Cape Town, Western Cape, 7786, South Africa
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Universitas Hospital
Bloemfontein, Free State, 9301, South Africa