New cancer drug BBI-355 trial halted early – what we know
NCT ID NCT05827614
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase trial tested a new oral drug called BBI-355, alone or with other targeted therapies, in people with advanced solid tumors that had extra DNA (oncogene amplifications). The study aimed to find the safest dose and check for side effects. It was terminated early, so full results are not available.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- BBI-355 (a CHK1 inhibitor drug)
- What this could lead to
- If successful, this could point toward a new treatment option for certain advanced cancers that have extra DNA in their cells.
- What could go wrong
- This was a very early (Phase 1/2) study that was terminated, so results are limited. The drug may not prove safe or effective, and it was tested only in people who had already tried all standard treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
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Dana Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Florida Cancer Specialists
Lake Mary, Florida, 32746, United States
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HealthONE
Denver, Colorado, 80218, United States
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MD Anderson Cancer Center
Houston, Texas, 77054, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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NEXT Oncology
San Antonio, Texas, 78229, United States
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NEXT Oncology
Fairfax, Virginia, 22031, United States
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NEXT Oncology - Dallas
Irving, Texas, 75039, United States
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SCRI Oncology Partners
Nashville, Tennessee, 37203, United States
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START Midwest
Grand Rapids, Michigan, 49546, United States
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Sarcoma Oncology
Santa Monica, California, 90403, United States
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The University of Kansas
Fairway, Kansas, 66205, United States
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UCLA Medical Center
Los Angeles, California, 90095, United States
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University of Washington, Fred Hutchinson Cancer Center
Seattle, Washington, 98109, United States
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University of Wisconsin
Madison, Wisconsin, 53792, United States
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