Specific developmental disorder

This phase 3 trial tests whether solriamfetol, taken once daily, can reduce ADHD symptoms in children aged 6 to under 12. Over 6 weeks, researchers compare the drug against a placebo using a standard rating scale. The goal is to see if solriamfetol is a safe and effective treatme…

This study tests whether solriamfetol, a medication taken once daily, can reduce symptoms of attention deficit hyperactivity disorder (ADHD) in adolescents aged 12 to 18. Over six weeks, participants receive either solriamfetol or a placebo to compare changes in ADHD symptoms. Th…

This trial tests whether a visual biofeedback method, delivered online, can help children aged 8 to 17 who struggle with the /s/ sound. Participants see a real-time visual display of their speech and are guided to match a target pattern for correct /s/ production. After a baselin…

This study follows 300 adults with Parkinson's disease, essential tremor, or dystonia who receive deep brain stimulation (DBS). DBS uses a device implanted in the chest to send electrical pulses to brain areas controlling movement. Researchers will track symptom severity, medicat…

This study tests whether a computerized brain-training program, called central executive training, can improve attention and behavior in young children with ADHD. Researchers will compare this training to standard behavioral parent training, and then test a combination of both. T…

This trial tests whether a high-intensity speech therapy program—five 30-minute sessions per week—works better than the traditional low-intensity approach of two sessions per week for children aged 4 to 12 with phonological speech sound disorders. The study will measure improveme…

This study tests whether a gentle electrical current applied to the scalp during reading lessons can improve reading skills in children aged 7 to 17 with dyslexia or reading difficulties. Half the participants receive active stimulation, while the other half receive a sham (place…

This trial tests whether combining aerobic exercise with a targeted reading therapy, called Phono-Motor Therapy, can improve reading skills in people who have reading difficulties after a stroke. Participants will receive both interventions, and researchers will measure changes i…

This study compares obstacle course training and neuromotor task training in 28 children aged 7-10 with developmental coordination disorder (DCD). Both programs run twice a week for 9 weeks and aim to improve motor planning and functional mobility. Researchers will measure skills…

This trial tests whether adding metacognitive training—exercises that help people think about their own thinking—to standard word-finding rehabilitation can improve language skills in people with chronic aphasia after a stroke. The study involves 18 participants who will receive …

This trial investigates whether combining two medications—reboxetine and methylphenidate—can reduce PTSD symptoms by improving attention and emotional regulation. Adults with PTSD will receive either the drug combination or a placebo for about a month, and researchers will measur…

This trial tests whether methylphenidate, a standard ADHD medication, can reduce attention and hyperactivity problems in children and adolescents with KBG syndrome, a rare genetic condition often accompanied by ADHD-like symptoms. Participants receive alternating blocks of the dr…

This phase 2 trial is testing whether an experimental tablet called ALKS 7290 can reduce ADHD symptoms in adults. About 312 adults with ADHD will take either the drug or a placebo daily for 4 weeks. Researchers will measure changes in symptom scores and watch for side effects to …

This trial compares two parenting programs for caregivers who have depression and are seeking help for their child's emotional or behavioral difficulties. The experimental program, ADAPT, is designed to address the unique emotional needs of depressed parents, while the control is…

This trial investigates an unapproved medical device designed to help control a specific disease. Participants receive the device to see if it can reduce symptoms or manage the condition. The study focuses on safety and effectiveness in people with the disease.

This study tests whether playing action video games can improve reading in children with dyslexia by training their visual attention. About 76 Cantonese-speaking children with dyslexia will be randomly assigned to play either an action game or a non-action game for 12 hours. Rese…

This study will test a traditional Chinese herbal formula called Pei Tu Ning Feng Tang in 60 children aged 4 to 15 with Tourette syndrome. Researchers will measure changes in tic severity, brain activity using a special light-based scanner, and markers in blood and stool. The goa…

This trial investigates whether a non-invasive brain stimulation technique called tACS, applied during speech therapy, can help people recover language abilities after a stroke. The study includes 120 adults who have had a left-hemisphere stroke and experience aphasia (difficulty…

This study tests whether giving choline supplements to pregnant women who drink heavily can reduce the negative effects of alcohol on their baby's growth and brain development. Choline is an essential nutrient that supports cell membranes and brain function. The trial compares da…

This study tests whether a group-based parenting program called the Chicago Parent Program can improve executive function—skills like self-control and focus—in 4- and 5-year-olds from low-income families. Children and their parents will be randomly assigned to the program or a co…

This study tests whether adding team-building tools—like team charters, communication handoffs, and performance monitoring—to an existing school-based ADHD program (the Collaborative Life Skills Program) makes it work better. Researchers will compare the enhanced program to the s…

This study is testing whether a cochlear implant is safe and effective for infants and toddlers who are deaf in one ear. Sixty children will receive the implant and be followed until age 5. Researchers will compare their hearing abilities to children with normal hearing and to th…

This study tests whether adding a gentle magnetic brain stimulation (TMS) to a standard behavioral therapy (CBIT) can help teens and young adults with chronic tics or Tourette syndrome better control their tics. About 60 participants aged 12–21 will receive either CBIT alone or C…

This study tests a new type of talking therapy called mentalization-based therapy (MBT) for young people aged 10-17 who struggle with aggressive or violent behavior. The therapy aims to help them understand their own feelings and those of others. Half of the 632 participants will…

This study tests whether a home-based computer cognitive training program (RehaCom) can improve attention and memory in adults with acquired brain injury, including stroke. Thirty participants will either receive the home program plus weekly in-person sessions, or standard in-per…

This pilot study tests a remote monitoring program (RAMP) for children with ADHD living in rural areas. 36 children aged 5-11 who are starting or restarting stimulant medication will be randomly assigned to receive either text-based symptom questionnaires or digital education han…

This early study tests a brain-computer implant that reads brain signals to help people with severe paralysis (from ALS, stroke, or spinal cord injury) communicate. The device aims to decode imagined speech and allow control of computers. Only 2 participants will be enrolled to c…

This study tests whether a common ADHD medication (OROS-methylphenidate) can help prisoners with ADHD manage their symptoms and reduce problem behaviors. About 150 adults in French prisons will receive either the drug or a placebo for several months. Researchers will track change…

This study follows 20 adults with severe, drug-resistant Tourette syndrome who receive deep brain stimulation (DBS) targeting a specific brain region. Researchers will check tic severity, mental health, and quality of life every year for five years after surgery. The goal is to u…

This study tests a stepped care approach for children aged 8-16 who struggle with anger, defiance, or aggression. All families start with a brief online parenting program. If more help is needed, they are randomly assigned to additional options, including virtual reality-assisted…

This study tests whether adding a 16-week cognitive remediation program (brain training using PRESCO® software) to standard ADHD medication (methylphenidate) improves daily functioning in adults with ADHD and at least one addiction. 248 participants will be split into two groups:…

This Phase 2 trial tests whether dexamfetamine, a stimulant used for ADHD, can safely and effectively treat both ADHD and moderate to severe depression in adults. 105 participants will receive either a fast-acting or long-acting version of the drug, or a placebo. The study is cur…

This study tests the safety of an experimental drug called EB-1020, taken once daily, in 180 children and adolescents with ADHD over 52 weeks. Researchers will monitor side effects and how well participants tolerate the medication. The trial is open to those who completed a prior…

This study tests a new medication called EB-1020 for children and teenagers with ADHD. It is a once-daily capsule that aims to reduce symptoms like inattention and hyperactivity. The trial involves 315 participants in Japan and China, comparing two doses of the drug against a pla…

This study compares two common stimulant classes (amphetamine and methylphenidate) and alpha-2 agonists to treat ADHD in 500 children aged 4-17 with autism. The goal is to find which medication works best and reduce the trial-and-error process. Parents and doctors will track symp…

This early study is testing whether a washed fecal transplant (WMT) can improve ADHD symptoms and related issues like sleep problems in children aged 3-17. The idea is that changing the gut bacteria might help the brain via the gut-brain axis. Fifty children will receive the tran…

This early-phase trial tests whether transplanting healthy donor gut bacteria (washed microbiota transplantation) can improve autism and ADHD symptoms in 80 children aged 3-17. The approach targets the 'gut-brain axis,' since many children with autism have gut microbiome imbalanc…

This study is testing a new test called the Five Digits Test (FDT) to see if it can measure a person's ability to stop automatic responses—a skill often affected in ADHD and autism. The FDT does not require reading, making it useful for people with different language backgrounds.…

This study is testing a computer program called DystoniaNet that uses artificial intelligence to help doctors diagnose isolated dystonia, a movement disorder. The trial will enroll 1000 people with dystonia or other conditions that look like it, such as Parkinson's disease or ess…

This study tests whether chewing xylitol gum during pregnancy can reduce the risk of preterm birth and low birthweight. 6,000 pregnant women in Malawi will chew either a high or low dose of xylitol gum or a placebo gum. The goal is to see if improving oral health with xylitol lea…

This study tests different combinations of an online program called CARRII, designed to help Native American women reduce their risk of alcohol-exposed pregnancy. Over 500 participants will be randomly assigned to one of eight versions of the program for three months. The goal is…

This study tests a special therapy for stroke patients in the hospital to help them avoid falls after they go home. Falls are common after a stroke and can cause injuries or fear of falling. The therapy includes extra exercises and education about fall risks. Researchers will tra…

This study tests whether adding extra supports—like telehealth coaching and practical help—to a group parenting program can prevent language delays in young children (12-42 months) of parents with substance use disorders. 244 parents will be assigned to the group program alone or…

This study tests three school-based programs to help high school students who are at risk for behavior problems like conduct disorder. About 120 students will be randomly assigned to a mindfulness program, a mindfulness program with a mobile app, or a life skills program. Researc…

This study tests a new behavioral therapy called PICTURE IT, delivered via telemedicine, to help people with aphasia after a stroke. The therapy uses pictures and spoken words to stimulate the right side of the brain, aiming to improve language skills. Researchers will compare it…

This study tests whether a culturally adapted version of Dialectical Behavior Therapy skills training (DBT-A-ST) helps teens aged 12-18 with emotional disorders like depression, anxiety, or ADHD. Participants are randomly assigned to either the DBT group or a standard support gro…

This study tests a program that offers mental health screening, therapy, and follow-up to pregnant women who are in the hospital for medical complications. About 50 participants will receive brief counseling and symptom tracking during their stay and for three months after. The g…

This pilot study at St. Jude Children's Research Hospital is testing whether a daily dose of extended-release methylphenidate (Ritalin) can safely improve attention, thinking, and school performance in children aged 8 to 17 with sickle cell disease. The trial will enroll 72 parti…

This study is testing whether playing special brain-controlled games at home can help school-aged children (ages 7 to 11) with mild to moderate ADHD pay better attention and feel less hyperactive. About 146 children will play these neurofeedback games over several weeks, and rese…

This pilot study tests whether the Voiceitt app can help people with speech impairments caused by conditions like cerebral palsy, stroke, ALS, or Parkinson's disease communicate more effectively. Participants use the app to see if it improves speech clarity and daily communicatio…

This study tests whether combining home-based brain stimulation (tDCS) with virtual speech therapy can improve communication in adults with primary progressive aphasia, a language disorder often caused by Alzheimer's disease. Eighty participants will receive either active or plac…

This study tests whether escitalopram (Lexapro), a common antidepressant, combined with computer-based naming therapy can improve language recovery in people with aphasia after a stroke. About 88 participants who had a left-hemisphere stroke within the past 5 days will receive ei…

This study tests whether teaching carers of children with global developmental delay to give aromatherapy massages can improve their caregiving experience and reduce stress. Around 30 carers in Hong Kong will attend an 8-hour training session, then give their child a 10 to 15 min…

This study tests whether a gentle brain stimulation technique (tDCS) combined with standard speech therapy can reduce stuttering severity and its negative impact on daily life. Sixteen adults who stutter will receive both treatments, and researchers will measure changes in speech…

This trial tests whether listening to music with embedded binaural beats can improve attention and memory in adults with ADHD. Forty adults will be randomly assigned to either a binaural beats group or a control group, both attending 12 supervised listening sessions over six week…

This study will compare two behavioral programs for children aged 9-12 with ADHD: the OutSMARTers group program and individual counseling. About 100 children will be randomly assigned to one of the programs or a short waitlist. Researchers will measure changes in behavior, emotio…

This study tests whether transcranial alternating current stimulation (tACS) can enhance language abilities in people with aphasia, a language disorder that often follows a stroke. Participants with post-stroke aphasia will receive both real and sham tACS while performing languag…

This study looks at whether reducing ultra-processed foods (like chips, soda, and packaged snacks) can improve thinking skills in children aged 10-15 with ADHD. Over 12 weeks, one group gets weekly online nutrition classes to swap junk food for whole foods, while the other group …

This trial tests whether 5-HTP, a natural chemical that the body turns into serotonin, can reduce distractibility in adults with high levels of ADHD traits. Participants take either 5-HTP or a placebo and then perform tasks that measure eye movements and reaction time to see if t…

This study tests whether the stimulant medication methylphenidate (Ritalin) can improve PTSD symptoms and thinking problems like poor memory and concentration in 70 Veterans. Each participant will switch between the drug and a placebo every 4-5 weeks over 20 weeks, without knowin…

This study tests whether a smartphone-based program is practical and helpful for young adults aged 18-25 who have ADHD and drink heavily. Participants use the app for 31 days to improve awareness and self-control around alcohol. The goal is to see if the app reduces binge drinkin…

This study explores whether hypnosis can help people with stroke, traumatic brain injury, or multiple sclerosis improve their attention and reduce fatigue. About 48 participants will receive hypnosis sessions alongside standard care, while researchers monitor brain activity with …

This trial tests whether daily music training—either piano practice or listening to music—can improve behavior and thinking in children with fetal alcohol spectrum disorder (FASD). Each child will do both activities for 12 weeks each, in a random order, with tests before and afte…

This trial tests whether using a weighted blanket at night and during the day can improve sleep in children aged 5-12 with ADHD who still have sleep problems despite standard care. Half the children will receive a weighted blanket, while the other half gets a non-weighted sham bl…

This study looks at whether a store-bought weighted blanket can help children aged 5-12 with ADHD who have trouble sleeping. 100 kids will use the blanket every night for 4 weeks, and researchers will track their sleep with a wrist monitor. The goal is to see if the blanket incre…

This trial tests a structured, 8-session program designed to help adults who stutter feel less anxious and more confident in job interviews. The program uses techniques like cognitive restructuring, voluntary stuttering, and simulated interviews to gradually reduce fear of negati…

This study tests whether low-intensity focused ultrasound (LIFU), a gentle sound wave technique, can safely improve speech fluency in people who stutter. Twenty adults who stutter will receive LIFU or a sham treatment, and researchers will measure changes in stuttering severity a…

This study tests whether a specialized speech therapy that focuses on word meanings can help people with mild-to-moderate semantic aphasia—a condition where brain damage impairs understanding and use of words. Participants first undergo a control period of standard language exerc…

This study tests whether a virtual reality program can help children with ADHD improve their attention by repeatedly exposing them to distractions in a simulated classroom. The idea is that, like getting used to a loud noise, children may become less reactive to distracting sight…

This study tests a group-based program called GEARS that teaches emotion regulation skills to adults with ADHD. Researchers will compare 150 participants who receive GEARS to those on a waiting list, measuring changes in emotional control, ADHD symptoms, and quality of life. The …

This pilot study tests whether repeated transcranial magnetic stimulation (rTMS) can reduce stuttering in adults. Two participants will receive 10 rTMS sessions, and researchers will measure changes in brain activity and speech. The goal is to see if this non-invasive treatment c…

This study tests whether giving cognitive behavioral therapy (CBT) in person, via video, or a mix of both works best for children aged 5-18 with anxiety or OCD. About 500 kids will be randomly assigned to one of three delivery methods. The goal is to find out which approach impro…

This study tests a smartwatch-based program designed to help people with post-stroke aphasia—a condition that impairs language—improve their ability to name objects. Over six weeks, participants receive daily prompts to name pictures and answer simple yes/no questions about the i…

This phase 2 trial is testing whether the drug lumateperone can reduce stuttering symptoms in adults with moderate to severe childhood-onset stuttering. Participants take either lumateperone (21 mg or 42 mg) or a placebo daily for several weeks. Researchers will measure changes i…

This study tests whether Jornay PM, a stimulant taken at night for ADHD, is safe and helpful for children who also have epilepsy. About 25 kids will take the medication and be monitored for improvements in ADHD symptoms. The goal is to ease attention and hyperactivity without tri…

This trial tests whether a therapy that blends Exposure and Response Prevention (ERP) with Habit Reversal Training (HbRT) can reduce both obsessive-compulsive and tic symptoms in adults with Tourettic OCD — a subtype where OCD and tic disorders overlap. Standard treatments usuall…

This trial tests whether sertraline, a widely used antidepressant, can reduce anxiety in children and teens aged 8 to 17 with neurodevelopmental disorders such as autism, ADHD, Fragile X syndrome, and Tourette syndrome. Participants receive either sertraline or a placebo for seve…

This study tests whether a structured behavioral therapy called CBIT can help children and teens aged 10–17 with chronic tics (Tourette syndrome or persistent tic disorder) gain better control over their symptoms. Participants receive 8 weekly CBIT sessions, learning to replace t…

This trial tests whether six months of group singing can improve mood, quality of life, and language recovery in stroke survivors with aphasia, while also supporting their personal caregivers. Half of the participants will attend weekly singing sessions; the other half will recei…

This study tests whether a short educational program can help adults with ADHD feel more satisfied and confident in managing their condition. The program combines group sessions with digital materials, covering self-help tools and treatment options. Researchers will compare this …

This study tests whether a gentle, non-invasive brain stimulation technique called tDCS can help people recover language abilities after a stroke that causes aphasia. Participants receive 14 sessions of tDCS over 7 days combined with speech therapy. Researchers measure language i…

This study tests whether a device that gently stimulates the forehead during sleep can help children aged 8 to 12 who have ADHD linked to prenatal alcohol exposure. The device, already cleared for general pediatric ADHD, is used at home by parents each night for four weeks. Resea…

This study compares word learning in late-talking toddlers (ages 2–3) who receive a behavioral treatment called VAULT. One group is taught words from categories they already know (like animals), while the other group learns words from less familiar categories. The goal is to see …

This study tests whether playing virtual reality games can improve cognitive skills like attention and memory in children aged 8 to 16 with ADHD. Participants will play four different VR games for 20 minutes a day, five days a week, for four weeks. The trial starts with a pilot p…

This study tests whether a precise form of brain stimulation (TMS) combined with language therapy can improve word-finding in people who have aphasia after a stroke. Fifty stroke survivors will receive either targeted or control stimulation during therapy sessions. The goal is to…

This study tests whether probiotics, a dietary supplement, can improve attention and brain-gut health in children aged 8 to 11 with mild ADHD. Half of the 80 participants will receive probiotics, and half a placebo. The main focus is on changes in attention test scores over time.

This study tests whether atomoxetine, a non-addictive ADHD medication, can improve attention, thinking skills, and quality of life in 160 veterans with PTSD who also have attention problems. Participants will receive either atomoxetine or a placebo for 12 weeks. The goal is to se…

This study tests a program called Invest in Play (iiP) for parents of children aged 6-12 with problem behaviors. About 180 families will be randomly assigned to the program or a control group. Parents will fill out surveys to see if the program reduces challenging behaviors and i…

This study compares two types of speech therapy for people with aphasia, a language disorder often caused by stroke. One therapy, called Semantic Feature Analysis (SFA), helps people name objects by describing their features. The other adds metacognitive strategy training (SFA+MS…

This study is testing a 12-week early intervention program for preschoolers (ages 2 to 5) with developmental disorders like autism or intellectual disability. The program provides 12 hours of therapy each week, either at a center or at home, aiming to improve social communication…

This study tests whether certain supplements—prebiotics, probiotics, omega-3s, and vitamin B1—can reduce ADHD symptoms in children aged 6 to 12. Over 12 weeks, 68 kids will receive either a gut-focused supplement, a brain-focused supplement, a combination, or a placebo. Researche…

This study looks at whether acupuncture can improve symptoms of ADHD in children ages 6 to 12. Researchers will give some kids acupuncture plus herbal medicine, and others just herbs, then compare results using parent surveys and interviews. The goal is to see if adding acupunctu…

This trial tests whether shining a specific type of near-infrared light on the forehead—called transcranial photobiomodulation (tPBM)—can improve attention and reduce impulsivity in adults with and without ADHD. Participants receive either active tPBM or a sham (fake) treatment f…

This study tests a non-invasive light therapy called transcranial photobiomodulation (tPBM) to see if it can improve attention, memory, and brain oxygen levels in adults with ADHD. Researchers will give repeated sessions of infrared light to the forehead area and measure changes …

This study tests whether a non-invasive brain stimulation technique called TMS, combined with language therapy, can improve speech in people who have aphasia after a stroke. Researchers will compare real TMS to a sham (fake) version in 63 participants who had a stroke 2 to 6 week…

This study tests whether a new type of virtual reality therapy can improve arm function in people who had a stroke. Fifty-four participants will try different versions of mirror therapy, some with added attention-focusing techniques. The goal is to see which approach works best f…

This study tests a speech therapy program for bilingual Spanish-English or Spanish-Catalan speakers with primary progressive aphasia, a condition that slowly damages language abilities. Sixty participants will receive personalized script training via video sessions, while 30 othe…

This study tests whether home-based video games can improve speech clarity and arm movement in children with cerebral palsy. Fifteen children aged 8-17 will play specially designed computer games for 30 minutes a day, 5 days a week, for 8 weeks. Researchers will measure changes i…

This study tests an educational support group program for people with progressive aphasia (a language disorder caused by Alzheimer's or other dementias) and their carepartners. The program includes group education, support sessions, and communication skills training. Researchers …

This study tests whether real-time fMRI neurofeedback can help teens aged 10-16 with Tourette Syndrome reduce their tics. Participants learn to control activity in a brain region linked to tics by watching their own brain activity on a screen. The trial compares this to a control…

This pilot study tests whether Tai Chi or exercise can reduce attention problems in college students with ADHD. Researchers will enroll 145 students and measure changes in inattention symptoms. The goal is to see if these non-drug approaches are feasible and worth studying furthe…

This study tests two types of speech therapy for adults with mild-to-moderate primary progressive aphasia, a condition that slowly impairs language. Researchers will compare the therapies in 200 participants to see which better improves communication and reduces caregiver burden.…

This study tests whether combining a gentle, non-invasive brain stimulation technique called rTMS with personalized language training can improve language skills in children aged 2 to 5 with global developmental delay. About 50 children will be split into two groups: one gets bot…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve word-finding in people who have trouble speaking after a stroke. Researchers will use MRI scans to guide the stimulation and see how the brain responds. The trial involves 45 participants …

This Phase 2 trial tests whether a single dose of cannabigerol (CBG), a non-psychoactive cannabis compound, can improve attention and reduce hyperactivity in adults with ADHD. 76 participants will receive either 80mg of CBG or a placebo, then complete computer and paper tasks mea…

This study tests whether a gentle electrical current applied to the brain can make speech therapy more effective for people with chronic aphasia (trouble speaking or understanding language) after a stroke. About 50 adults who had a stroke at least six months ago will receive eith…

This study is testing whether speech amplification devices can help people with Parkinson's disease and related conditions who have a soft, weak voice (hypophonia). Researchers will work with 100 participants to measure how well these devices improve speech loudness, clarity, and…

This study tests whether a personalized brainwave training (neurofeedback) can reduce ADHD symptoms like inattention and hyperactivity in children aged 6-13. Forty children will receive either standard or personalized neurofeedback during school holiday camps. Researchers will ch…

This study tests if trauma-adapted yoga, added to usual care, can improve mental health and quality of life for 180 teens diagnosed with ADHD or PTSD. Participants will be randomly assigned to a yoga group or a waiting list. The study also explores if online yoga is a feasible op…

This study tests whether a cannabis compound called cannabigerol (CBG) can reduce ADHD symptoms like inattention and hyperactivity in teenagers. Sixty adolescents aged 12 to 17 who have not responded well to other treatments will receive either CBG oil or a placebo for 12 weeks. …

This program provides early access to ecopipam for children, teens, and adults aged 6 to 50 with Tourette's disorder. The goal is to see if the drug is safe and tolerable over the long term, while also tracking quality of life. Participants receive the medication under their doct…

This study tests a cognitive behavioral therapy (CBT) program called ADHD&me, designed to improve self-esteem in young people aged 16-25 with ADHD and low self-esteem. Participants will attend seven therapy sessions and complete questionnaires about their self-esteem, masking beh…

This study tests if a digital app called LEXURE can improve language skills in people who have trouble speaking after a stroke (aphasia). About 116 adults who had a stroke at least 3 months ago will either use the app or do workbook exercises. The goal is to see if the app helps …

This study tests whether a non-invasive brain stimulation technique called theta burst rTMS can reduce ADHD symptoms in children aged 9 to 15. Thirty participants with an ADHD diagnosis will receive the treatment, and researchers will measure attention and symptom severity. The g…

This study tests whether a mindfulness-based program can help adults with Tourette syndrome or persistent tic disorders reduce their tics. Participants will either learn mindfulness techniques to manage urges or receive standard relaxation and coping support. The goal is to see w…

This study tests whether virtual reality (VR) games can make speech therapy more fun and improve how often people practice. Researchers will enroll 30 adults with voice disorders at the Glenrose Rehabilitation Hospital. Participants will use VR speech therapy games at home and in…

This study tests whether Ayre's Sensory-Motor Integration Exercises, a type of play therapy, can help children with autism spectrum disorder (ASD) improve their sensory processing and motor skills. The trial will involve 28 children aged 9-11, with half receiving 12 sessions of t…

This study tests whether combining two proven treatments—computer-based working memory training and parenting classes—can improve ADHD symptoms in children ages 8-12. Researchers will enroll 200 kids with ADHD and compare the effects of doing the computer training first, then par…

This study tests a behavioral program called MomMA for pregnant women with ADHD. The program teaches skills to manage ADHD symptoms and related mood issues during pregnancy and after birth. Researchers will compare it to usual care in 80 participants to see if it is acceptable an…

This study tests whether adding a gentle brain stimulation technique (tDCS) to a type of talk therapy (DBT skills training) can improve ADHD symptoms in adults. Sixty adults with ADHD will receive either real or fake tDCS before weekly therapy sessions for 10 weeks. The goal is t…

This study tests whether playful physiotherapy can improve emotional self-regulation and quality of life in children aged 7-12 with ADHD or autism. Twenty-five children will take part in movement- and play-based group sessions. Parents will report changes in behavior and well-bei…

This study is testing whether a web-based platform called Cognishine can help adults with cognitive and speech problems after a brain injury or stroke. Instead of using paper exercises, patients will do therapy on a tablet or computer. The goal is to see if this digital approach …

This study tests a program called Thrive that helps young adults (ages 18-25) with fetal alcohol spectrum disorders (FASD) set personal goals and build support networks. Participants are randomly assigned to start the program right away or after a delay, and then to work individu…

This study is testing whether a liquid form of leucovorin (a type of folate) can improve social communication and language in young children with autism. Researchers will enroll 80 children ages 2.5 to 5 years who have a specific antibody linked to folate transport. The study las…

This study tests Jornay PM, a once-daily ADHD pill taken at night, in 30 adults aged 18-60. The goal is to see if it improves focus, emotional control, and daily function from morning through early evening. Researchers will measure symptom changes over 10 weeks.

Some head and neck cancer survivors develop velopharyngeal dysfunction (VPD), where the soft palate doesn't close properly, causing nasal-sounding speech and trouble swallowing. This study tests a simple injection that plumps up the back of the throat to improve closure. Research…

This study tests a new speech therapy technique for people with aphasia (trouble speaking) after a stroke. Instead of copying a therapist's voice, participants will practice speaking along with an AI-cloned version of their own voice. The goal is to see if this personalized appro…

This study tests a personalized, virtual speech therapy program for people with primary progressive aphasia (a type of dementia that affects language) and their communication partners. The goal is to see if the program improves communication and quality of life. About 30 particip…

This study is testing whether a 10-week music-based program done at home on a tablet can help people recover from a stroke. The program includes rhythm exercises, singing, playing a xylophone, and listening to music. Researchers will compare 100 stroke survivors who do the music …

This small study from Stanford tests whether rapid, non-invasive brain stimulation can reduce the urge to hoard. Ten adults with hoarding disorder will receive the treatment and report changes in their acquiring habits. The goal is to see if this safe, outpatient procedure can ea…

This study tests whether a safe, noninvasive brain stimulation technique called HD-tDCS can reduce stuttering symptoms like repetitions and blocks. Fifty adults who stutter will receive a single session of stimulation and complete speaking tasks before and after. The goal is to s…

This phase 2 trial is testing a topical gel and mouthwash made from olive oil, betaine, and xylitol (XCM-OM118) to see if it can reduce severe oral mucositis (painful mouth sores) in head & neck cancer patients receiving radiation. The study will enroll 63 adults and track how ma…

This study tests three different naming treatments for people with aphasia, a language disorder often caused by stroke. The goal is to see which approach best helps participants remember words and use them in daily life. Thirty adults with chronic aphasia will practice naming pic…

This study tests a program called BRIDGE for mothers with depression and their children aged 3-7 who have attention or behavior problems. The program aims to improve children's self-control and reduce problem behaviors by supporting mothers' mental health. About 60 families will …

This study tests a portable robotic device called PhiCube that helps children aged 4 to 18 with neuromotor disorders (like cerebral palsy) or coordination difficulties improve arm movement. The device uses games to make therapy fun, with 30 sessions over 3 months. Researchers wil…

This study tests a Spanish-language program called Unstuck and On Target for children ages 8-11 with autism and/or ADHD. The program helps kids improve skills like planning and flexibility, and supports their caregivers. About 40 families will either join the program right away o…

This study tests a telehealth program called RELAX that teaches teens with ADHD and their parents skills to manage strong emotions and reduce family conflict. About 60 families will be split into two groups: one gets the RELAX program, the other gets educational materials. A smal…

This study tests whether a safe, non-invasive brain stimulation technique called theta burst stimulation (TBS) can boost language recovery in people with post-stroke aphasia. 45 adults with non-fluent aphasia will receive either real TBS (targeting the left or right brain) or a s…

This study is testing a non-invasive brain stimulation technique called temporal interference stimulation to see if it can safely improve language abilities in people with post-stroke aphasia. The trial will enroll 40 adults who have language problems after a stroke. Researchers …

This study tests whether a mild electrical current applied to the back of the brain (cerebellar tDCS) can boost language therapy for people who have trouble finding words after a stroke. Sixty adults who had a left-hemisphere stroke at least six months ago and still have aphasia …

This study is testing a driving simulator called ADRIS 2.1 for teens aged 13-18 with ADHD. The simulator tracks driving errors like running red lights or speeding, and some participants will get 12 training sessions over 6 weeks. Researchers want to see if the simulator can impro…

This study tests whether a 12-week high-intensity exercise program can improve language, thinking, and physical health in 120 adults with aphasia (trouble speaking or understanding language) after a stroke. Participants are randomly assigned to either high-intensity or low-intens…

This study tests whether adding an AI app to standard behavioral parent training helps families with children aged 5-12 who have disruptive behaviors like irritability or ADHD. Forty parents will either attend 8 weekly online training sessions alone or with 24/7 access to an AI v…

This study tests whether adding hand gestures to standard speech therapy helps Cantonese speakers with aphasia find words more easily. 90 participants will first receive verbal-only therapy, then after a break, switch to therapy that combines gestures with speech. Researchers wil…

This study tests a non-drug device (Monarch eTNS) that gently stimulates a nerve in the face to help ease ADHD symptoms in children and teens aged 7 to 17. About 60 participants will use the real device or a sham (fake) device every night for four weeks. The main goal is to see i…

This study tests a type of talk therapy called Acceptance and Commitment Therapy (ACT) for teenagers who have both social anxiety disorder and oppositional defiant disorder. The therapy aims to help teens become more flexible in their thinking and behavior. Researchers will measu…

This study tests whether combining Transcranial Magnetic Stimulation (TMS) with speech therapy can improve language in people with mild aphasia after a stroke. About 24 adults who had a left-brain stroke at least 6 months ago will receive either real or fake TMS along with 10 day…

This study looks at whether Adderall XR can reduce ADHD symptoms in children and teens (ages 8-18) who also have autism. Participants will take the medication or a placebo for 4 weeks and complete brain scans to measure changes in attention, impulsivity, and memory. The goal is t…

This study tests whether immersive virtual reality (VR) therapy can improve cognitive, motor, and social skills in children aged 8 to 18 with ADHD, autism, or cerebral palsy. Participants will use the CAREN VR system, which provides interactive exercises with visual, sound, and t…

This study tests a computer-based training program called FOCAL+ for teens with ADHD aged 16-19 who have a driver's license. The training teaches them to limit how long they look away from the road while driving. Researchers will measure if the training reduces risky glances duri…

This study tests personalized speech therapy delivered online for people with primary progressive aphasia (PPA), a condition that slowly destroys language skills. Researchers will enroll 30 adults with mild PPA and tailor exercises to their specific variant. The goal is to see if…

This study tests whether a medication called SPN-812 (viloxazine) can safely reduce ADHD symptoms in children aged 4 to 5. About 286 kids will receive either the drug or a placebo for 6 weeks. The goal is to see if the drug improves attention and reduces hyperactivity better than…

This study tests whether virtual reality exercises can improve attention problems in people who have had a brain injury, like a stroke or traumatic brain injury. About 135 participants will either do VR-based cognitive games or standard pen-and-paper exercises for 20 sessions. Th…

This study tests whether the My Health Coach app can improve quality of life and daily functioning for adults with fetal alcohol spectrum disorders (FASD). Two hundred participants will be split into two groups: one gets the app right away, the other waits 12 weeks. Everyone comp…

This study tests whether a gentle electrical current applied to the brain (tACS) during language therapy can help people with post-stroke aphasia name objects more accurately. 64 adults with aphasia will receive either real or sham stimulation while practicing word-naming tasks. …

This study tests whether joining a community choir for 12 weeks can improve communication and quality of life for people with chronic aphasia (trouble speaking or understanding language) after a stroke. Fifty participants will be randomly assigned to either choir sessions plus ho…

This study tests a smartphone app called Zenicom that provides personalized speech therapy exercises for people who have trouble speaking after a stroke (aphasia). Twenty adults with recent stroke and aphasia will either receive standard speech therapy alone or standard therapy p…

This study tests whether virtual reality (VR) simulations can help college students improve their public speaking skills and reduce anxiety. 80 students will be randomly assigned to either a VR training group or a wait-list control group. Researchers will measure speech rate, pau…

This study tests a supplement called Stasis to see if it can reduce side effects like sleep problems, irritability, and brain fog caused by ADHD stimulant medications. About 90 adults aged 18-55 who take stimulants for ADHD will take either the supplement or a placebo for three m…

This study tests a digital health intervention for children aged 8-12 with ADHD. The intervention uses a smartwatch and smartphone app to help children and parents work together to improve self-regulation and reduce ADHD symptoms. Sixty children will be randomly assigned to recei…

This study tests whether a virtual reality headset, combined with focus feedback, can help 252 young adults aged 18-25 with ADHD concentrate better on homework and studying. Participants use a Meta Quest 3 VR headset that blocks distractions, and some also get feedback on their f…

This study is testing a behavioral treatment called CBIT (Comprehensive Behavioral Intervention for Tics) in 200 youth who have tic disorders, such as Tourette's, along with related emotional problems like anxiety or depression. The goal is to see if CBIT can reduce tic severity …

This study at Duke University Hospital tests whether changing the timing of physician rounds improves communication satisfaction for high-risk pregnant patients who need long hospital stays. Currently, patients get two visits: an early morning bedside round and a later team discu…

This study looks at whether omega-3 fatty acids can reduce depression symptoms in young people aged 12-25 with major depressive disorder. Over 12 weeks, 60 participants will take either omega-3 supplements or a placebo. Researchers will track mood changes, gut bacteria, and blood…

This study is testing whether high-dose omega-3 fatty acids can reduce ADHD symptoms like inattention and impulsivity in children and adolescents who are deficient in omega-3. About 100 participants will take omega-3 supplements or a placebo for 12 weeks. The goal is to see if th…

This study tests whether a gentle brain stimulation technique (tDCS) combined with computer-based thinking exercises can improve attention, memory, and problem-solving in children aged 8 to 17 who were exposed to alcohol before birth. About 70 kids will be randomly assigned to re…

This study tests a personalized coaching program for parents and early intervention professionals to reduce problem behaviors like aggression and screaming in children up to 5 years old with developmental delays. Researchers will observe and track changes in behavior during short…

This study tests a personalized, non-invasive brain stimulation technique (TMS) in 60 children aged 5-18 with tic disorders. The goal is to reduce tic severity and understand how the brain changes with treatment. Children also receive behavioral guidance, such as avoiding trigger…

This study tests two support programs for parents with advanced cancer who have children aged 10 to 25. One program provides information and tips; the other adds exercises and emotional support. Researchers want to see which helps parents communicate better and feel more confiden…

This study tests whether immersive virtual reality (VR) training can help children aged 6 to 13 who struggle with handwriting. Researchers will enroll 12 children and use a special tool to measure writing quality before, during, and after VR sessions. The goal is to see if VR mak…

This study tests a new parent support program that uses short educational videos sent via text message. The videos teach strategies to handle difficult situations like transitions or waiting. Researchers want to see if parents find the program helpful and if it improves child beh…

This study compares two non-drug treatments for teens aged 13-17 with ADHD: Organizational Skills Training (OST) and Mindfulness-Based Intervention (MBI). Both involve eight 90-minute sessions. Researchers will measure changes in ADHD symptoms, daily functioning, and emotional co…

This study tests whether using a mild electrical brain stimulation device at home for four weeks can help adults with ADHD. Researchers will compare two different stimulation strengths to see if symptoms and thinking skills improve. The trial involves 60 adults aged 18 to 65 with…

This study tests whether adjusting the timing of speech therapy sessions can help people with aphasia (trouble speaking after a stroke) remember words better and use them in daily life. About 32 adults with chronic aphasia will practice naming pictures using a computer program th…

This pilot study tests whether a non-invasive device that stimulates the vagus nerve through the ear can help people with chronic aphasia (trouble finding words) after a stroke. Thirty-six participants will use the device at home while doing computer-based speech therapy for six …

This small pilot study tests whether a brain-computer interface combined with electrical stimulation can improve swallowing difficulties and language problems in people who had a stroke at least three months ago. Ten participants will use the device for hand rehabilitation while …

This study tests whether a speech therapy that involves parents can improve early social and communication skills in children aged 6 months to 5 years with neurodevelopmental disabilities. One group gets the parent-focused therapy, while the other gets standard speech therapy. Re…

This study tests whether a playful 'Animal Fun' program can improve motor skills in 40 children aged 6 to 12 with developmental coordination disorder (DCD). Kids are split into two groups: one does the Animal Fun activities, the other does daily physical play. After six weeks, re…

This study tests a digital therapy called NDTx-02, designed to help children aged 5 to 12 with ADHD or autism improve their executive function—skills like planning, focus, and self-control. The study will involve 48 participants and compare the digital therapy to standard care. T…

This study tests whether a technique called high-definition transcranial direct current stimulation (HD-tDCS) can improve word-finding difficulties in people who had a traumatic brain injury at least a year ago. The device delivers a very low electrical current through electrodes…

This study tests whether a type of brain stimulation called iTBS can improve working memory and impulse control in 50 adolescents aged 12-18 with ADHD. Participants receive three short sessions of magnetic pulses each day for ten days, targeting either the left DLPFC or right Pre…

This pilot study at Duke University compares two behavioral treatments—organizational skills training (OST) and mindfulness-based intervention (MBI)—for 30 teens aged 13-17 with ADHD. Both treatments involve eight 90-minute sessions. Researchers will measure changes in ADHD sympt…

This study tests a new approach to help children ages 7 to 11 who have trouble saying the /s/ sound (like in "snake"). Participants will do very short 10-minute speech lessons over video chat four times a week for eight weeks. The goal is to see if these brief, frequent sessions …

This study tests a device worn on the forehead during sleep to see if it can reduce ADHD symptoms in children with autism. About 60 children will use the device nightly for 8-12 weeks. Half will start with a real device and half with a fake one; later, those who got the fake one …

This study aims to create a communication device that automatically learns and adapts to each user's physical abilities. It is designed for people with severe motor impairments who cannot use standard keyboards or speech. The system will be tested in 20 adults and children aged 6…

This study in Norway is testing whether nature-based group activities—like outdoor education and therapy—can improve quality of life for 240 children and youth with ADHD, autism, or Tourette's. Participants will take part in 10- to 12-week programs in schools or healthcare settin…

This study tests a 15-week shared reading program called Sit Together and Read (STAR) for children ages 4 to 5 with developmental language disorder. Caregivers are guided to read with their child using specific techniques to build print and letter knowledge. The study also looks …

This study tests whether a gentle, noninvasive electrical current applied to the scalp can improve speech fluency in adults who stutter. Researchers will give 80 participants three sessions of brain stimulation while they read aloud, then measure changes in brain activity and stu…

This study tests a program called Mio-Training for 40 children aged 8–16 with ADHD. The training combines memory exercises, coordination tasks, and questions to improve self-awareness and thinking skills. Researchers will measure changes in metacognitive awareness and executive f…

This study tests whether a behavioral parent education program (PEAK) can help reduce ADHD symptoms in 180 children aged 3 to 5 who show early signs of the condition. Parents will receive the training either face-to-face or online, and researchers will compare outcomes to a waitl…

This study tests whether a virtual reality (VR) game can help children aged 8-12 with ADHD improve their attention, self-control, and executive functions. The game mimics real-life situations, and parents also receive guidance on supporting positive behavior. Researchers will com…

This study tests whether playing a special online game for 20 minutes, four times a week, can improve memory and thinking speed in people with multiple sclerosis. Researchers will compare the game group to a control group receiving standard care. The trial aims to enroll 150 adul…

This study tests whether a gentle electrical current applied to the front of the brain (tDCS) can reduce fatigue and improve language and attention in people who have had a stroke. Sixty participants will receive either real or fake tDCS during 10 sessions of speech therapy. The …

This observational study looks at how the brain responds when watching others perform actions, focusing on the mirror neuron system. Researchers will measure brain activity in healthy adults and infants, including those at risk for developmental delays, using EEG and fNIRS. The g…

This study looks at facial features of males aged 2 to 40 with creatine transporter deficiency (CTD), a genetic disorder that causes intellectual disability, seizures, and behavioral issues. Researchers will examine photos of participants to see if they share common facial traits…

This study aims to find differences between organic tics (related to diagnosed disorders) and functional tics (caused by problems in brain-body communication). Researchers will use sensors to measure muscle activity and brain waves in 75 adults with tics and healthy volunteers. P…

This study looks at how children who stutter process speech sounds compared to children who do not stutter. Researchers will use hearing tests, brain wave recordings (EEG), and brain scans (fMRI) to measure brain activity. The goal is to understand the differences in speech proce…

This observational study aims to understand why some people are more impulsive or compulsive than others. Researchers will use brain scans, genetic tests, and behavioral surveys in 1,100 participants aged 6 to 80, including those with ADHD, OCD, autism, and conduct disorder. The …

This study looks at children and teens ages 7-17 who have severe mood problems like chronic anger, sadness, or irritability, along with extreme tantrums. Researchers will use interviews, tests, and brain imaging to understand what happens in the brain. Up to 2,350 participants wi…

This study looks at how memory, learning, and language differ in adults with aphasia (a language disorder from brain injury) compared to healthy adults and seniors. Researchers will test 600 participants using memory and language tasks. The goal is to better understand these cogn…

This study investigates how children with cleft palate, their parents, and speech-language pathologists perceive high-intensity versus low-intensity speech therapy. High-intensity therapy involves five 30-minute sessions per week over two 2-week periods, while low-intensity thera…

This study screens up to 5,000 healthy volunteers and people at risk for psychiatric or neurodevelopmental disorders like autism. Participants undergo interviews, cognitive tests, and other evaluations to see if they qualify for future research studies at NIH. The goal is to buil…

This study aims to learn more about childhood-onset behavioral, psychiatric, and developmental disorders by observing people of all ages who have these conditions, along with their family members. Researchers will collect medical histories, perform psychiatric assessments, and ma…

This study looks at whether a special syringe called EpiFaith® helps anesthesia residents learn how to place labor epidurals more quickly. 34 residents with little experience will each perform 20 epidural placements using either the standard syringe or the EpiFaith® syringe. Rese…

This trial investigates whether methylphenidate, a common ADHD medication, affects brain circuits differently in adults with ADHD alone, those with ADHD plus mood disorders, and healthy individuals. Using EEG and MRI, researchers will compare brain activity after a single dose of…

This study is collecting blood and other samples from 5,000 children and young adults (under 21) who are already taking certain medications as part of their regular care. The goal is to understand how these drugs move through and affect children's bodies, so doctors can prescribe…

This study gives aripiprazole, a drug that affects dopamine, to 40 adults who stutter to see how it changes brain activity during speech. Researchers use brain scans and audio recordings to measure how the brain processes sound before and during speaking. The goal is to better un…

This study collects medical information and samples from people with hearing, balance, taste, smell, voice, speech, or language disorders. Researchers aim to use this data for future studies and to find candidates for other research. Participants receive standard care, and no exp…

This study explores how the brain learns and remembers speech movements. Researchers will have 330 healthy adults say words while hearing their own voice slightly altered through headphones. The goal is to understand which brain areas help us adapt and retain new speech patterns,…

This study looks at how changing sleep schedules affects attention, mood, and the internal body clock in teens aged 13-17 with ADHD. Over three weeks, participants follow different sleep patterns—including a short-sleep week and a week with extended sleep timed either to match or…

This study tests a new approach called RIGHTimeCPV, designed to help children with poor-prognosis cancer and their families talk more openly with doctors about the future. Participants choose a communication companion and attend a special visit to share their preferences. The goa…

This study tests whether showing an aphasia identification card helps healthy volunteers better understand a person with aphasia. 160 service workers will listen to sentences from a speaker with aphasia, with or without seeing the card first. Researchers will measure comprehensio…

This trial asks whether a gentle electrical current applied to the scalp during language lessons can speed up and improve how adults learn a new language. Healthy adults who are learning or planning to learn a language are randomly assigned to receive either real or sham (placebo…

This study follows 1,000 children who have surgery for a brain tumor in the back part of the brain. Up to 1 in 4 of these children develop a condition called Cerebellar Mutism Syndrome, where they lose the ability to speak. Researchers want to understand why this happens and how …

This study tests a new program for adults in prison who have both ADHD and substance use disorder. The program includes workshops to improve care and support. Researchers will check if the program is acceptable and if it improves quality of life.

This study from Stanford University is looking at how a 6-week math training program changes brain activity and thinking skills in children with math learning disabilities (dyscalculia). About 180 children aged 6-12 will do math problems on a tablet at home and get weekly one-on-…

This study investigates how the gut-brain axis—the communication network between gut bacteria and the brain—might be involved in pediatric obsessive-compulsive disorder (OCD). Researchers will compare gut microbiome, blood metabolites, brain imaging, and EEG data from children wi…

This study looks at how six short, 15-minute self-regulation techniques — like exercise, breathing, aromatherapy, music, virtual reality, and tapping — affect the body and brain of one woman with ADHD and stabilized bipolar disorder. Researchers will measure heart rate, brain wav…

This study follows pregnant women and their children from the first trimester through toddlerhood to explore how stress, early social experiences, and genetics interact. Using simple at-home activities like questionnaires, video recordings, and cheek swabs, researchers will look …

This study examines the prevalence of neurodevelopmental disorders like ADHD and autism among youth who have committed crimes. Researchers will analyze records from juvenile offenders to explore how these conditions relate to the types and frequency of criminal behavior. The goal…

This study looks at how the brain processes and controls speech in healthy adults. Researchers want to understand how people notice their own speech mistakes and learn new sounds. About 117 English-speaking adults with normal hearing and no neurological conditions will take part.…

This study explores whether a gentle, non-invasive brain stimulation technique called transcranial alternating current stimulation (tACS) can help improve language recovery in people who have lost speech abilities after a stroke. Researchers will also test the same stimulation in…

This study interviews bereaved parents and oncologists to understand how they discussed uncertainty during a child's cancer treatment. The goal is to find better ways for doctors and families to communicate about what the future may hold. Participants include parents whose child …

This study looks at how the brain processes auditory feedback during speech in people with aphasia, a communication disorder often caused by stroke. Researchers will test 50 adults with aphasia and 50 healthy adults using speech tasks, EEG, and fMRI. The goal is to find brain mar…

This trial tests whether training novice bronchoscopists using computer-generated 'digital twin' models of real patient airways — showing a wide range of normal anatomical variations — can help them learn the procedure faster than traditional training with a single, uniform airwa…

This study looks at how the brain uses feedback to control speech in 90 adults aged 18-50, including people who stutter, have dyslexia, and those with typical speech. Participants will do speech tasks, have an MRI scan, and receive mild brain stimulation to see how different brai…

This study tracks how tic symptoms change in 30 youth aged 12-17 with Tourette syndrome or chronic tic disorders. Participants receive 8 sessions of behavioral therapy (CBIT) and complete daily surveys, wear a device to track physiology, and perform weekly tasks. The goal is to i…

This study aims to understand how the brain learns and remembers new ways of speaking. Researchers will use brain scans (fMRI) and magnetic pulses (TMS) to see which brain areas are involved. 50 healthy, right-handed, fluent English speakers with normal hearing will participate. …

This study tests a web-based decision-support tool designed to help families and doctors make shared decisions about whether a child should go on chronic home ventilation. Half of the participating families use the tool, while the other half receive usual care. Researchers then m…

This study records brain activity from people with movement disorders like Parkinson's disease, essential tremor, and dystonia. Researchers use scalp electrodes or existing deep brain stimulators to measure electrical signals. The goal is to find patterns linked to symptoms, whic…

This study aims to see if a communication skills training program designed for rehabilitation professionals (like physical and speech therapists) is practical and helpful. About 25 staff members at St. Jude Children's Research Hospital will take part. The goal is to boost their c…

This study uses transcranial magnetic stimulation (TMS) to investigate how the brain processes language in people who have had a stroke and developed aphasia, as well as in healthy volunteers. Participants receive targeted magnetic pulses to specific brain areas while performing …

This study tests whether a special training program called mastery learning can improve how anesthesiology residents handle difficult conversations with patients and families. Residents are randomly assigned to either the mastery training or standard learning. Researchers then me…

This study works with over 126,000 adults and clinic staff to improve how primary care clinics identify and accommodate patients with communication disabilities, such as speech or hearing problems. Researchers will test tools to help clinics record these needs in electronic healt…

This study looks at how genes and brain scans can help predict recovery from aphasia, a language disorder that often follows a stroke. Researchers will enroll 90 adults aged 40-90 who have had a stroke and have trouble speaking or understanding language. By understanding these bi…

This study looks at how men and women differ in voice quality after having their voice box removed (total laryngectomy) and using a special voice prosthesis. Researchers will ask 12 participants to complete surveys and voice tests. The goal is to understand if women have poorer s…

This study looks at whether fidgeting—specifically using a smart fidget ball—can help adults with ADHD pay better attention and manage emotions. Researchers will measure processing speed, memory, and heart rate in 109 adults with ADHD. The goal is to see if simple movements can b…

This study compares three types of exercise programs—traditional physical activity, virtual reality, and video game-based—to see how they affect physical fitness and attention in healthy adolescents aged 10-18. Participants will be split into three groups and follow their assigne…

This pilot study will screen 150 homeless adults in French shelters for autism, ADHD, and intellectual disability using interviews and questionnaires. The goal is to find out how many have these conditions, which may have contributed to their homelessness. Results could help tail…

This study looks at how jaw surgery affects speech in people with bite problems like open bite or underbite. Researchers will record patients' speech and tongue movements before and after surgery to see what changes. The goal is to understand why many jaw surgery patients have sp…

This study looks at whether simple, painless tests of eye movements and heart rate can help predict which children with ADHD will benefit from medication and which will have side effects. Researchers will measure these factors before children start medication and then check how w…

This study adapts PlayReadVIP, a program that coaches parents on positive interactions during reading and play, for use in family child care homes. Researchers will enroll 240 providers to see if the program improves provider confidence and children's literacy behaviors. The goal…

This study follows 50 children and adults with Baker Gordon Syndrome, a rare genetic disorder, to track how the condition changes over time. Participants will undergo brain scans, EEGs, and genetic testing, and complete developmental assessments. The goal is to create better tool…

This early-stage study tests a brain implant called BrainGate in just 3 people with severe paralysis or speech loss from conditions like ALS or spinal cord injury. The goal is to see if the device is safe and can let users control a computer cursor or other tools by thought alone…

This study observes 60 children with severe hearing loss who received cochlear implants before age 2. Researchers will track their speech therapy sessions and language skills over time to see which therapy approaches and how much therapy lead to better language development. The g…

This study looks at people who have changes in a gene called FOXP1, which can cause developmental delays, speech problems, and autism-like traits. Researchers will use interviews, play-based assessments, and genetic tests to better understand these conditions. The goal is to lear…

This study explores whether a gentle electrical current applied to the brain (called transcranial random noise stimulation) can improve how adults learn to connect letters with sounds — a key skill for reading. Researchers will enroll 60 right-handed, German-speaking adults aged …

This study aims to find the best way to train early intervention providers to deliver high-quality services to children under 3 with communication delays or autism. Researchers will compare two training models for a program called Project ImPACT, measuring how well therapists lea…

This observational study will follow 1,460 girls and women (age 10+) with and without ADHD across Canada. Participants complete surveys about their mental health, hormones, and life experiences. The goal is to build a detailed picture of how ADHD affects females over their lifesp…

This study aims to see if two brain measurements taken with Transcranial Magnetic Stimulation (TMS) can help guide ADHD treatment in children aged 8 to 12. Researchers will test these measurements for reliability, how they change with a single dose of methylphenidate (Ritalin), a…

This study explores whether a special MRI technique can help people who have had a stroke improve their reading. Participants will practice controlling their own brain activity using real-time feedback from the MRI scanner. The goal is to retrain the brain's language areas to wor…

This study looks at whether a parent's ability to manage their own emotions can make behavioral training more effective for children with ADHD. Researchers will work with 65 parents and their children (ages 5-12) to see if better parental emotion regulation leads to fewer behavio…

This study records brain activity from epilepsy patients who already have electrodes implanted for medical reasons. While listening to sentences and stories, their neural signals are analyzed to map how the brain processes language. The goal is to understand the brain's language …

This study tests a smartphone app called Footsteps that helps school aides track behaviors of children aged 4-17 with conditions like autism, ADHD, or oppositional defiant disorder. The goal is to see if the app improves how consistently and accurately aides record data, and whet…

This study tests whether virtual reality-based assertiveness training can strengthen communication skills in oncology nurses. Sixty nurses working in oncology clinics for at least six months will participate. The training includes sessions on assertiveness techniques, handling cr…

This study explores whether artificial intelligence can simplify the language used in informed consent forms for clinical trials. Researchers will test AI tools like ChatGPT and NotebookLM to rewrite these forms and see if people understand them better. The study involves 230 par…

This study follows 140 adults with Tourette syndrome for two years to see how stress from life events impacts tic severity, depression, anxiety, and quality of life. Participants complete interviews and questionnaires about their tics, mood, and daily functioning. The goal is to …

This study tests whether a computer model can predict which reading treatment works best for people who developed dyslexia after a stroke. Twelve participants will each try two different therapies—phonomotor treatment and semantic feature analysis—for 60 hours each. The goal is t…

This study looks at sleep and internal body clocks in 250 children aged 6-9 with ADHD. Researchers will use wearable sensors, parent surveys, and a lab test measuring melatonin (a sleep hormone) to see how sleep patterns relate to thinking skills and mental health. The goal is to…

This study looks at whether a gentle, non-invasive brain stimulation technique can temporarily change brain activity linked to working memory in teens aged 12-18 with ADHD. Researchers will measure brain waves during memory tasks before and after stimulation. The goal is to under…

This study uses brain scans (fMRI) to compare brain activity when adults who stutter produce stuttered versus non-stuttered speech. Researchers aim to understand which brain circuits are involved. Fifty adults aged 18-65 who stutter will participate. This is not a treatment study…

This study records brain activity from epilepsy patients who already have electrodes implanted for seizure monitoring. While they perform thinking tasks like memory and attention games, researchers watch how different brain areas talk to each other. The goal is to better understa…

This study involves 136 children with ADHD who also have high levels of irritability or aggression. Researchers will measure tiny brain signals (called ERPs) while children do tasks, then see if those signals can predict which kids get the most benefit from stimulant medication. …

This study uses fMRI brain scans to understand how the brain works in teenagers with borderline personality disorder (BPD). Researchers will compare brain activity in teens with BPD, teens with ADHD, and healthy teens. The goal is to learn more about the brain areas involved in s…

This study is collecting information from 80 adults who have both ADHD and an addiction. Researchers will track their symptoms and daily functioning over 12 months to better understand how these conditions affect each other. The goal is to gather data that could improve future tr…

This study looks at how 8-month-old babies' brains process speech sounds, using a non-invasive EEG cap. Researchers want to see if differences in brain activity can predict language skills at 18 months, especially in infants with a family history of language or learning disorders…

This study follows 120 children aged 3-6 who stutter or have typical speech, to learn why some recover naturally. Kids complete speech tests, wear brain-monitoring caps, and speak in virtual reality classrooms. Researchers track brain activity, heart rate, and skin responses to f…

This study aims to better understand how children aged 8 to 16 with neurodevelopmental disorders (like autism or ADHD) process social information. Researchers will use a new set of tests to measure skills like recognizing emotions and understanding others' thoughts. The goal is t…

This study tests a two-week online program designed to help kindergarten and elementary school teachers better support autistic children and those with developmental delays. About 70 public school teachers will either take the program or receive standard materials. Researchers wi…

This study aims to develop and test a new scale that measures how well people with aphasia communicate in everyday life, not just in lab tasks. Researchers will enroll 50 Italian-speaking adults with language disorders after a stroke. The goal is to create a tool that considers g…

This study tests whether speech therapy delivered via video call works as well as traditional in-clinic therapy for people with aphasia, a language disorder caused by stroke. One hundred adults who had a stroke at least a year ago will receive either remote or in-person therapy. …

This study looks at language difficulties in people with psychosis, including those at risk, experiencing a first episode, or diagnosed with schizophrenia. Researchers will give a full language test to 90 patients and compare results with a healthy control group. The goal is to b…

This study uses magnetoencephalography (MEG), a non-invasive brain scan, to compare brain signals in 1,500 children with neurodevelopmental disorders (like epilepsy, autism, ADHD) and healthy children. The goal is to improve diagnosis and understanding of these conditions. No tre…

This study tests whether teaching parents to talk more with their babies during regular well-child visits can improve language development. Researchers will enroll 400 parent-child pairs and compare those who receive the 'Talk With Me Baby' coaching to those who get standard care…

This study looks at how children aged 7 to 17 with developmental coordination disorder (DCD) walk while also doing a thinking task or a moving task. Researchers will compare their walking patterns to those of typically developing children. The goal is to gather detailed movement …

This study looks at 60 adults with severe hoarding disorder who are already in contact with social services in Copenhagen. Researchers want to find out how many also have other serious mental health conditions and test a new approach: a team of doctors and social workers who reac…

This study is creating a shared database of children who have received deep brain stimulation (DBS) for movement disorders like dystonia, epilepsy, or Tourette syndrome. By pooling data from multiple hospitals, researchers hope to answer key questions about who benefits most and …

This study follows 30 people aged 12 to 21 with chronic tic disorders as they go through 8 sessions of CBIT, a well-established behavioral therapy. Researchers will track tic severity, controllability, and other factors to see what predicts a good response. The goal is to underst…

This study looks at how daridorexant, a sleep medication that blocks the brain chemical orexin, affects emotional processing and learning in 62 healthy adults. Participants take a single dose of the drug or a placebo and then complete tasks that measure emotional responses and le…

This study tests a new method to help prisoners better understand what they are agreeing to when joining a research study. Researchers will compare an enhanced 'teach-to-goal' consent process with the standard one in 100 adults with ADHD in prison. The goal is to improve ethical …

This study looks at whether creating a personalized profile for children with disruptive behavior and their parents can help predict which treatment will work best. About 200 children and their parents will take part. The goal is to see if matching therapy to a child's specific e…

This study looks at how the brain makes sense of sentences. Researchers will record brain activity from electrodes already placed in the brains of people with epilepsy for medical reasons. Participants read or listen to sentences word by word and pick a picture that matches. In s…

This study aims to better understand sensory symptoms in adults with Tourette syndrome or chronic tic disorders. About 214 participants will fill out yearly questionnaires about urges, attention, mood, and quality of life. The goal is to gather information, not to test a treatmen…

This study looks at how two brain areas—the subthalamic nucleus and the ventral intermediate nucleus of the thalamus—help us learn and produce speech. Researchers will temporarily turn deep brain stimulation (DBS) on or off in 80 people with Parkinson's disease or essential tremo…

This study investigates whether brain surface recordings can decode Mandarin Chinese speech, including tones, from imagined speech. About 50 participants with brain tumors or epilepsy will have temporary electrodes placed during surgery, and 10 people with severe speech loss will…

This study looks at how sleep, physical activity, and daily rhythms relate to ADHD symptoms and brain function in 200 children. Kids wear a wristband for two weeks and complete cognitive tests and MRI scans. The goal is to better understand why ADHD affects people differently and…

This study tests whether combining a one-time session of brain stimulation (rTMS or electrical scalp stimulation) with emotion regulation training helps people with mood, anxiety, or related disorders better control their emotions. 240 participants will learn either cognitive res…

This study looks at how often people with Tourette syndrome have trouble being assertive and managing emotions. About 350 adults with Tourette syndrome will fill out online surveys about their symptoms, quality of life, and mood. The goal is to better understand these challenges,…

This study follows 500 people with primary progressive aphasia, a condition that slowly damages the brain's language areas. Researchers will use brain scans and language tests to map how the disease progresses over time. The goal is to better understand the disease, not to test a…

This observational study looks at how acquired brain injury affects speech and breathing in adults with dysarthria. About 100 participants will have their voice recorded and take breathing tests. The goal is to find better ways to identify the severity and type of dysarthria, hel…

This study looks at why people move their eyes differently when searching for something. Researchers will measure attention and self-control skills in 225 healthy adults aged 18-65, then see how these skills relate to eye movement patterns. The goal is to understand individual di…

This study looks at 500 Polish children aged 3 to 6 to understand what factors are linked to developmental delays. Researchers will test thinking, language, and social-emotional skills, and ask parents about their child's behavior. The goal is to find patterns that could help ide…

This study looks at how the brain learns and remembers new ways of speaking. Researchers will use brain stimulation and brain scans in 160 healthy adults to see which brain areas are important for speech motor learning and retention. The goal is to better understand the basic sci…

This study aims to understand which parts of the brain help us learn and remember new ways of speaking. Researchers will use brain scans and magnetic pulses to observe brain activity in 120 healthy adults. The goal is to learn more about how speech motor learning works, not to te…

This study looks at 50 people with OCD or Tourette syndrome to find clear differences between compulsions and tics. Participants wear a smartwatch and a portable brain-wave recorder at home and in the lab. The goal is to help doctors choose the right treatment by using objective …

This study uses high-resolution 7-Tesla MRI to examine how a part of the brain called the mediodorsal thalamus supports flexible thinking and decision-making. One hundred healthy adults will perform computer tasks while their brain activity is scanned. The goal is to understand w…

This study looks at how to help pediatric primary care offices better use a proven program called DOCC for children with behavior problems and ADHD. The program involves counseling and support for families. Researchers will compare different strategies to help clinic teams adopt …

This study looks at whether a substance called PlGF in the umbilical cord and placenta can act as an early warning sign for brain damage in babies whose mothers drank alcohol during pregnancy. Researchers will compare PlGF levels between 60 pairs of mothers and babies—some with a…

This study tests whether a special eye-tracking device (Gaize) can identify changes in eye movement patterns caused by long-term use of psychiatric medications. Researchers will observe 50 adults with conditions like ADHD, depression, or anxiety who have been on medication for ov…

This study looks at how a brain area called the pre-SMA affects impulse control in teens with ADHD. Researchers will use a non-invasive technique called TMS to stimulate this area and measure brain activity. The goal is to better understand ADHD, not to provide treatment. 40 teen…

This research study collects health information from 10,000 people with brain inflammation conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to find disease subtypes and…

This study investigates how attention influences the brain's ability to inhibit or stop actions. Researchers will test 120 participants, including healthy volunteers and people with conditions like ADHD or stroke-related neglect, using computer-based tasks that measure eye and ha…

This study looks at how children and adults with Developmental Coordination Disorder (DCD) sense touch and body position, and how they update their body image when using tools. Researchers will compare 280 participants with and without DCD to see if sensory deficits explain motor…

This study looks at how the brain works in people who have attempted suicide compared to those who have only thought about it. Researchers will use simple computer tasks to measure things like impulse control and attention. The goal is to find patterns that might help predict who…

This study tests a virtual training program called ABCs that teaches healthcare providers how to have better conversations with patients about serious illness. The program includes online modules and live workshops. Researchers will compare providers who receive the training righ…

This study looks at whether mothers who have fibromyalgia and also care for a child with ADHD experience a higher disease burden. Researchers will compare 50 such mothers with 50 mothers who have fibromyalgia but whose children have no psychiatric conditions. The goal is to under…

This study watches how babies move in their first months to see if it predicts their development later. Researchers will video-record preterm and full-term infants and score their movements. When the children turn 18 and 36 months old, parents will fill out a questionnaire about …

This study looks at whether a regular beat in music helps children with cerebral palsy and typical development learn dance moves. Researchers will teach 68 kids a short dance with and without a steady rhythm, then check how well they remember it. The goal is to understand if rhyt…

This study is testing different types of computer-based brain training in 780 teenagers, some with ADHD and some without. The goal is to find out which training methods—like adding game elements or varying the number of tasks—work best for improving memory and focus. Participants…

This study looks at how hearing sensitivity (hyperacusis) might help language skills in children and adults with Williams syndrome. Researchers will use EEG and NIRS brain scans along with questionnaires to compare participants with Williams syndrome, Down syndrome, and typical d…

This study looks at whether using a preferred communication method (like a touch talker or picture cards) helps people with intellectual or developmental disabilities maintain positive behavior changes and avoid relapse. Researchers will compare two groups: one starting with a pr…

This study tests whether cognitive remediation—brain exercises with coaching—can improve thinking skills and reduce aggression in 30 forensic inpatients with conditions like psychosis, ADHD, or substance use. Participants will do exercises and be compared to an active control gro…

This study watches 80 children (ages 8-15) with ADHD and emotional or behavioral problems to see how standard treatments like medication and group therapy affect their symptoms. Researchers compare treated kids to those on a waiting list, using questionnaires, computer tests, and…

This study looks at how teaching children to recognize and play with sounds in words (phonological awareness) can boost their reading and spelling skills. Researchers will compare two teaching approaches in 720 prekindergarten and kindergarten children who are behind in sound awa…

This study surveys 160 French dentists and dental trainees to understand how 'attentional tunneling' (focusing too much on one detail) can cause errors in dental care. Researchers will use questionnaires to measure knowledge of this bias and identify risk factors. The goal is to …

This study explores whether a child's genetic makeup influences how well they respond to the ADHD medication methylphenidate. Researchers will track symptom changes and side effects in 400 participants aged 6-24 across Western Canada. The goal is to find genetic markers that coul…

This study observes how preschool boys with and without motor difficulties catch a moving pendulum. Researchers measure movement timing and accuracy to understand how children plan and adjust their actions. The goal is to improve early diagnosis and support for kids with coordina…

This study tests a dual executive function training program for 288 primary school children aged 6-12 with ADHD, dyslexia, or autism. The program includes weekly group sessions to improve thinking, emotional control, and behavior. Researchers will measure changes in memory, atten…

This study tests a brain implant that reads signals from the brain to help people who have lost the ability to speak fluently communicate through a computer just by trying to talk. It involves up to 2 participants with conditions like spinal cord injury or ALS. The main goal is t…

This study tracks 250 teens with ADHD aged 16-17 over two years using smartphone apps and a Fitbit. The goal is to understand what changes happen during this transition and what predicts negative outcomes. Researchers will then co-design a smartphone app with teens to help them m…

This study aims to learn more about sensory and movement difficulties in adolescents with tic disorders, like Tourette syndrome. Researchers will compare teens with and without tics using questionnaires, brain wave tests, and motor tasks. The goal is to identify factors that affe…

This study uses advanced brain scans, including a special PET tracer called AV-1451, to track changes in the brains of 50 people with progressive apraxia of speech (a disorder that affects the ability to coordinate speech movements). Researchers at Mayo Clinic will compare these …

This study looks at how drinking alcohol and the way couples talk about sex can lead to sexual violence between partners. Researchers will bring in 240 couples from the Denver area to a lab, where some will drink alcohol and others won't, and then test their reactions. The goal i…

This study looks at how children with developmental language disorder (DLD) learn patterns in speech and grammar. Researchers want to see if a general difficulty with learning sequences links problems with sounds and sentence structure. The goal is to create better, earlier tests…

This study follows 1,000 people who have certain genetic changes (hnRNP and others) that may cause developmental delays, autism, seizures, or muscle problems. Researchers collect medical records, school reports, and questionnaires to see how these gene variants affect behavior, t…

This study tests whether adding working memory training to math tutoring helps first graders at risk for math disabilities more than math tutoring alone. 300 children will be randomly assigned to one of three groups: combined memory and math training, math with reading instructio…

This registry enrolls 5,000 pregnant women aged 18-45 who take psychiatric medications like antidepressants or ADHD drugs. Researchers track infant health for one year after birth to see if these medications increase the risk of major birth defects. The goal is to provide better …

This study looks at how children who stutter perform on rhythm tasks compared to children who don't stutter. Researchers will test rhythm perception and production once a year for three years in 500 children. The goal is to understand how rhythm skills might be linked to brain ac…

This study collects medical information and biological samples (like blood or tissue) from up to 12,000 people with leukodystrophies—rare disorders that damage the brain's white matter. Researchers will use this data to find new genetic causes, develop biomarkers for future trial…

This study uses brain imaging (fMRI and MRS) to see how a single dose of methylphenidate changes brain activity and glutamate levels in 30 adults with ADHD. Participants will receive both the drug and a placebo in a double-blind crossover design. The goal is to find brain-based m…

The Dragonfly study is an international observational project tracking the development of 250 children and adults with CTNNB1 neurodevelopmental syndrome. Researchers will collect medical history, perform neurological exams, and use questionnaires to understand how symptoms and a…

This study looks at how children with and without Developmental Coordination Disorder (DCD) learn balance tasks using virtual reality. Researchers will measure movement patterns and brain activity during a 30-minute session and again after one week. The goal is to understand diff…

This study looks at whether how a child stands and walks can help predict ADHD. Researchers will measure foot pressure and posture in 100 middle school students, half with ADHD symptoms and half without. They will use machine learning to see if these physical measurements can acc…

This study is testing whether a non-invasive brain stimulation technique called tDCS can improve executive functions—like working memory, attention, and decision-making—in people with conditions such as traumatic brain injury, depression, bipolar disorder, schizophrenia, ADHD, bo…

This registry will enroll 450 adults with tic disorders to study how tic severity relates to quality of life, and whether this relationship differs between men and women. Participants will complete questionnaires about tics, mood, and daily functioning. The goal is to better unde…

This study looks at how a new type of partial denture made from titanium using digital design and milling affects speech. Twelve people with missing teeth will get these dentures, and researchers will measure how clear and understandable their speech is. The goal is to see if tit…

The purpose of this study is to understand how transcranial magnetic stimulation affects how quickly, easily, and accurately a person read. Transcranial magnetic stimulation is a technique that uses magnetic fields to briefly affect how well certain brain regions function. The in…