Specific developmental disorder

This trial tests whether a smartphone app can enhance parent management training (PMT) for children aged 8 to 13 with disruptive behavior disorders, such as conduct disorder or ADHD. Parents receive 12 weekly PMT sessions, and half also use a digital tool with videos, a resource …

This study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…

This study tests a brain-computer interface called BrainGate2 in people with expressive aphasia, a condition where stroke damage makes it hard to speak. Researchers place small sensors in the brain areas that control speech, then record brain activity while participants try to sp…

This trial tests whether combining a gentle brain stimulation technique called tDCS with reading and fine motor training can improve reading skills in 9-year-old boys with developmental dyslexia. The study targets two brain areas involved in reading and hand movements, and partic…

This trial is testing whether an experimental medication called centanafadine, taken once daily as extended-release capsules, can help adults with attention-deficit/hyperactivity disorder (ADHD) who also experience emotional dysregulation—difficulty managing emotions like irritab…

This phase 2 trial explores whether fecal microbiota transplantation (FMT) is safe, tolerable, and practical for adolescents aged 13–17 with ADHD. Participants receive oral FMT capsules after bowel prep, alongside antibiotics, to see if changing gut bacteria can influence ADHD sy…

General anesthesia in early childhood may raise the risk of ADHD-like behaviors and learning problems later on. This trial tests whether a non-invasive device delivering synchronized 40-Hz light and sound can help restore brain function after surgery. Researchers will monitor bra…

This trial tests a 12-week home-based program called SPRINT for infants aged 7-15 months who were born preterm or have a family history of conditions like ADHD, autism, or developmental delay. Parents use an app to guide daily play activities aimed at improving parenting skills a…

This study tests whether Foquest, a once-daily extended-release methylphenidate capsule, is safe and effective for treating ADHD in adults aged 65 and older. Participants take the medication for about 10 weeks, starting at 25 mg and adjusting up to 100 mg based on response. The m…

This study tests a fully wireless brain-computer interface (BCI) that aims to decode attempted speech in real time for people with locked-in syndrome (LIS), often caused by ALS or stroke. The implant records brain signals from areas controlling the mouth and throat, then translat…

This study tests a computer-based practice method to help people with aphasia—a language disorder often caused by stroke—retrieve words more easily. Participants practice naming pictures with or without cues and receive feedback, repeating items until they meet a learning goal. T…

This trial tests whether the MIND diet, a brain-healthy eating plan rich in vegetables, berries, nuts, and fish, can reduce ADHD symptoms in children aged 6 to 12 who are not taking medication. Over 12 weeks, half the children follow the MIND diet while the other half receive sta…

This phase 3 trial tests whether viloxazine extended-release capsules, taken once daily, can safely reduce ADHD symptoms in Korean children and adolescents aged 6 to 17. Participants receive either the drug or a placebo for 8 weeks, with doses adjusted based on response. The stud…

This early study tests a small, wireless brain implant designed to help people with severe speech problems communicate by thought. Four adults with conditions like locked-in syndrome or ALS will get the implant and learn to control it. The main goal is to see if the device is saf…

This study tests a special type of talk therapy (cognitive-behavioral therapy, or CBT) designed for adults with ADHD who are in prison. Researchers will compare it to a standard prison program and a waitlist. They want to see if the therapy reduces ADHD symptoms, depression, anxi…

This study looks at whether a special oral nutritional supplement, combined with dietary counseling, can improve growth in children who are not growing as expected. About 216 children will be randomly assigned to receive either the supplement plus counseling or counseling alone. …

This study compares two treatments for teens aged 12-19 with oppositional defiant or conduct disorders. One group gets mentalization-based therapy (MBT), which helps teens understand their own and others' thoughts and feelings. The other group gets standard psychiatric care plus …

Researchers are testing a device called the Virtual Eggs Test (VET) to see if it can measure hand dexterity in children and young adults with cerebral palsy or developmental coordination disorder. The test involves carrying fragile objects across a platform without breaking them,…

This study tests a new system called AHEF designed to help doctors diagnose attention-deficit/hyperactivity disorder (ADHD) in children aged 6 to 12. The trial includes children with possible ADHD symptoms as well as healthy children, and measures how accurate and safe the system…

This study is testing a new cognitive assessment called the ExéSem battery, designed to help doctors tell the difference between language problems caused by memory loss versus those caused by thinking difficulties. Researchers will enroll 140 people, including those with Alzheime…

This study will test a machine-assisted system that uses five simple behavioral tasks—like responding to their name or pointing—to screen toddlers for autism. Researchers will enroll 1,000 children aged 1.5 to 2.5 years, including those with autism, developmental delays, language…

This study compares three types of therapy for children aged 8 to 16.5 with severe irritability. Participants will receive either exposure-based cognitive behavioral therapy, parent management training, or supportive psychoeducation over 12 sessions. The goal is to see which appr…

This study tests whether brief, 1-2 minute videos featuring personal stories from other parents can reduce stigma and improve help-seeking among parents of children aged 6-18 with depression, ADHD, or substance use problems. Researchers will recruit 1,600 parents online and rando…

This trial tests whether a telehealth program called Babble Boot Camp can improve early communication in babies born very preterm (before 32 weeks). Parents in the treatment group join weekly 15-minute coaching sessions with a speech pathologist for six months, learning activitie…

This study tests whether Neuromotor Task Training (NTT) can help autistic children aged 6 to 10 improve a specific motor skill they find difficult in daily life, such as catching a ball or putting on a coat. Each child works with a therapist to practice a chosen skill, with the t…

This pilot study tests a new therapy called Syntactic-Semantic Visual Configuration Intervention (SSVCI) for Urdu-speaking children aged 6 to 12 who struggle to form phrases and sentences. The therapy uses visual cues and structured activities to help children understand and prod…

This study tests whether a gamified virtual reality (VR) program can help children with ADHD improve their social skills. Children aged 6 to 12 will be randomly assigned to either the VR training, traditional social skills training, or a waitlist. Both training groups will attend…

This trial tests whether cognitive behavioural therapy for insomnia (CBT-I), with or without bright light therapy, can improve sleep and other outcomes in adolescents with ADHD who also have insomnia and a late sleep schedule. Participants aged 10-24 will receive CBT-I plus eithe…

This trial tests a five-session psychoeducation program designed to help parents of children with ADHD prepare for and cope with disasters. The program covers disaster preparedness, crisis communication, behavior management, emotional regulation, and post-disaster recovery. Resea…

This study tests whether a home-based music program can improve attention and thinking speed in people who have had a stroke. About 36 Malaysian stroke survivors with mild to moderate cognitive issues will take part. They will use music exercises at home, with help from a caregiv…

This randomized trial tests whether adding animal-assisted therapy (AAT) — structured sessions with a trained dog and/or rabbits — to standard rehabilitation can improve motor abilities, independence, and quality of life in older adults with dementia who are hospitalized in a med…

This trial tests whether a smartphone app called LISTEN can help people with brain tumors who have trouble speaking (aphasia) communicate more easily. The app uses artificial intelligence to adapt to each user's needs and can be used with voice input and output. Researchers will …

This trial tests whether a structured, task-focused occupational therapy program delivered at school can improve handwriting, fine motor skills, and visual-motor integration in second- and third-graders who struggle with these skills. Children will be randomly assigned to either …

This trial tests whether a two-week tongue-strengthening exercise, done with a non-invasive device, can improve speech fluency in people with tongue-tie or slurred speech. The exercise relies on muscle resistance training, not medication or electronics. Researchers will measure c…

This study tests a new, non-drug treatment for veterans with ADHD who still struggle with impulsivity despite medication. The treatment, called intermittent theta-burst stimulation (iTBS), uses magnetic pulses to gently stimulate brain areas linked to self-control. Thirty-five ve…

This study investigates whether a synbiotic supplement—a mix of probiotics and prebiotics—can improve emotion regulation and reduce gastrointestinal problems in adults with ADHD. Participants take either the synbiotic or a placebo capsule daily for 12 weeks. The main focus is on …

This phase 1 trial tests whether low-energy focused ultrasound can safely and temporarily reduce tics in people with Tourette syndrome. Twenty participants aged 16 and older receive ultrasound to deep brain regions or the motor cortex, or a sham treatment, across four sessions. T…

This study tests whether adding electroacupuncture at specific acupoints (Xuanzhong and Tongli) to standard speech therapy improves language recovery in people with post-stroke aphasia. Participants receive daily electroacupuncture sessions for four weeks, plus speech therapy. Th…

This trial tests whether a gentle, non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) can reduce inattention in adults with ADHD. Forty adults with ADHD will receive either real or fake tDCS for five days in a row. Researchers will meas…

This study looks at whether posture and tongue position affect how children pronounce Hebrew sounds. Researchers will test if adding muscle-strengthening exercises to regular speech therapy helps kids learn correct pronunciation faster. About 80 children with and without speech i…

This study will test whether adding music therapy to standard physical therapy helps children with spastic cerebral palsy improve their concentration and walking. Forty children aged 5 to 7 will either receive physical therapy alone or physical therapy combined with rhythmic musi…

This study tests whether a 10-week therapeutic climbing program can improve motor skills and confidence in 16 children with Developmental Coordination Disorder (DCD). The program uses a problem-solving approach called CO-OP and is led by occupational therapists. The goal is to se…

This study tests whether an AI-based app called HiDongDong can improve speech in children aged 2 to 14 who have trouble pronouncing words. Forty-eight children will either use the app at home for 20 minutes a day, five days a week, or receive standard speech therapy. The goal is …

This study will test if acupuncture can reduce tics (uncontrolled movements or sounds) in children aged 5 to 18. Researchers will also use special brain scans to see how acupuncture might affect the brain. The goal is to find a safe, non-drug treatment for tic disorders.

This study tests whether daily iron supplements can improve restless sleep and ADHD symptoms in 70 children with ADHD who have low iron levels. Participants will take either iron or a placebo for 3 months, and their sleep and attention will be measured using motion-sensing leg ba…

This study tests whether intensive music therapy can improve thinking skills like memory, attention, and decision-making in people recovering from a stroke. It will include 36 adults in Malaysia who had a stroke within the last 3 months and have mild to moderate cognitive problem…

This study tests a daily oral medication called SCI-110, made from cannabinoids, to see if it can safely reduce tics in adults with Tourette syndrome. About 164 adults aged 18 to 65 with moderate to severe tics will receive either the drug or a placebo, then switch after 12 weeks…

This study explores whether a non-invasive brain stimulation technique called tDCS can be practically used during routine speech therapy for people who have had a stroke and now have aphasia (trouble speaking or understanding language). Researchers will enroll 30 stroke survivors…

This trial tests whether an intensive, personalized speech therapy program (ICAP) helps people with post-stroke aphasia communicate better and feel better. 334 adults who had a stroke at least 3 months ago will be randomly assigned to either ICAP (100 hours over 4 weeks) or stand…

This study compares two treatments to help 150 children aged 8-11 with developmental language disorder learn passive sentence structures. One treatment uses repetition and listening, while the other teaches grammar rules directly. Children will be tested before, right after, and …

This study tests whether a mild electrical current applied to the scalp (tDCS) can improve naming ability in people who have trouble speaking after a recent stroke. Twenty-eight adults with aphasia will receive either real or sham stimulation over five days. The goal is to see if…

This study looks at whether a therapy called Acceptance and Commitment Therapy (ACT) can help fathers of children with special needs feel more flexible in their thinking and improve their mental health. About 50 fathers will take part, with half getting ACT and the other half rec…

This study aims to see if online speech therapy works as well as face-to-face sessions for children aged 5 to 11 with repaired cleft palate. Sixty-four children will receive 30-minute speech therapy twice a week for 10 weeks, either online or in person. Researchers will measure i…

This study tests whether a virtual reality system (VRRS) can improve executive functions like memory, planning, and attention in 50 children aged 8-12 with ADHD. Kids will do 12 sessions of VR-based cognitive exercises over 6 weeks. Researchers will also check if these skills hel…

This study will test whether adapted karate training can improve self-regulation, daily function, and social participation in children aged 6-12 with ADHD. Fifty-five participants will either receive karate training first or wait, then switch. The training involves two 60-minute …

This study tests whether a non-invasive device that gently stimulates a nerve in the ear can help people over 70 recover swallowing after a stroke. Twenty participants will receive either active or sham stimulation alongside standard speech therapy for three weeks. Researchers wi…

This study tests if a diet rich in fiber and fermented foods can reduce core ADHD symptoms in adults aged 18-50. Two hundred participants will be randomly assigned to either this special diet or standard healthy eating advice for 12 weeks. Researchers will track changes in sympto…

This study tests whether a special type of speech training using five musical tones can help people with aphasia (trouble speaking) after a stroke. Researchers will enroll 120 adults who had a stroke and have non-fluent aphasia. Participants will receive either five-tone therapy …

This study tests whether playing a virtual reality game called Electrical Maze can improve sustained attention in neurodivergent children aged 9 to 18, including those with autism, ADHD, or learning differences. Over 6 weeks, 40 participants will play the VR game twice a week for…

This study compares voice therapy delivered in-person versus via telehealth for adults aged 55 and older with age-related voice problems. Thirty participants will receive four sessions of PhoRTE® voice exercises either face-to-face or through video calls. Researchers will measure…

This study tests a special light therapy (850 nm) on 66 adults who had a stroke within the past year and now have trouble speaking or understanding language (aphasia). The goal is to see if shining this light on the head can improve brain activity and language skills. Participant…

This study compares two medications, methylphenidate and guanfacine, to see which works better for treating ADHD in children ages 3 to 5. About 370 children with moderate to severe ADHD will take one of the drugs, and doctors will rate how much their symptoms improve. The goal is…

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce symptoms of ADHD and autism in children and teens aged 6-19. Participants will receive either real or sham (fake) stimulation over three weeks. The goal is to see if it is safe and if it im…

This study tests whether intensive music-based rhythm training can improve attention, thinking, and reading in children aged 8 to 10 with complex neurodevelopmental disorders (like ADHD plus dyslexia). Six children will take part in a structured program, and researchers will meas…

This Phase 2 pilot study will test whether a single high dose of psilocybin (the active ingredient in magic mushrooms) combined with speech therapy can improve fluency and reduce struggle in 25 adults who stutter. Researchers will measure changes in stuttering severity and brain …

This study looks at whether an 8-week exercise program (balance, strength, and stretching) can improve physical fitness in children aged 7-14 with specific learning disabilities. 18 children will be split into an exercise group and a control group. The goal is to see if regular e…

This study will test a new, non-invasive treatment called transcranial photobiomodulation (tPBM) for children with ADHD. The treatment uses light to stimulate the brain. Researchers will enroll 54 children aged 6 to 18 to see if tPBM can improve ADHD symptoms, sleep, and brain ac…

This study looks at whether children with ADHD and their parents will actually use a digital app called LUSHA for three months. The app is designed as a game to motivate behavior change and improve parent-child interaction. Researchers will track how often families use the app an…

This study tests a shortened version of Parent-Child Interaction Therapy (PCIT) that uses videos and 360-degree virtual reality films to help parents manage disruptive behavior in children aged 2-7. Fifteen families will receive up to 10 therapy sessions. Researchers will measure…

This study tests whether listening to music for 30 minutes a day for 8 weeks can improve attention, language, and quality of life in people with aphasia after a stroke. Researchers will compare music listening to audiobook listening and a control group. The trial involves 45 adul…

This study looks at whether structured breathing exercises can help 12th graders reduce exam anxiety, improve attention, and boost academic performance. Sixty students preparing for university entrance exams will practice specific breathing techniques over several sessions. Resea…

This study looks at brain activity in teenagers aged 10 to 17 with ADHD, OCD, or no diagnosis. Researchers will use EEG, MRI, and MEG to measure brain signals while participants do computer tasks. The goal is to understand how the brain controls thinking and behavior, which may h…

Researchers at Duke University are studying how natural estrogen changes across the menstrual cycle relate to sleep and ADHD symptoms in girls aged 11 to 15. Participants will wear a Garmin device to track sleep, provide hormone samples, and answer quick surveys about mood and fo…

Researchers at Assiut University are asking whether ADHD symptoms in medical students are linked to depression, anxiety, and lower grades. About 52 undergraduate medical students will fill out questionnaires that screen for adult ADHD, depression, and anxiety. The study also coll…

Researchers are studying how stress levels in caregivers of children with ADHD relate to the social support they perceive and the time children spend on screens. The study will include 385 caregivers of children aged 6 to 12 diagnosed with ADHD. Participants will fill out questio…

This study tests two different math training methods—speeded practice and arithmetic strategy training—in children aged 6 to 12, including those with math learning disabilities like dyscalculia. Researchers will measure changes in arithmetic speed, accuracy, and brain activity us…

This study looks at stroke survivors who have mild aphasia—a condition causing language difficulties. Researchers want to see if these individuals also struggle with 'executive control' of language, which helps us manage and switch between words and ideas. By testing 30 participa…

This study looks back at the medical records of 60 adults with head and neck cancer who received radiation therapy, with or without chemotherapy, and used a topical mouth rinse made from olive oil, betaine, and xylitol. The goal is to see how often severe mouth sores (oral mucosi…

This study investigates whether a familiarization session before a treadmill time-to-exhaustion test can reduce learning effects and improve measurement consistency. Healthy, physically active adults will complete a practice trial followed by an experimental trial. Researchers wi…

This study looks at whether using simulation (practicing with mannequins or actors) helps first-year nursing students become better communicators compared to traditional teaching methods like role-play and group discussion. Fifty students will be randomly assigned to either simul…

This study tests a program to help people with certain genetic mutations share their results with at-risk relatives and make informed decisions about genetic testing and care. About 2100 adults in the U.S. who speak English or Spanish will take part. The program provides free gen…

This trial tests an AI-powered teaching platform called iLN, which uses a large language model to help medical students learn about lupus nephritis. Fifty fourth-year medical students are randomly assigned to either use iLN or attend a traditional PowerPoint lecture. The study me…

This study explores whether a flipped learning approach—where students review digital materials before class and use class time for active problem-solving—improves clinical decision-making and academic performance in third-year physiotherapy students. Participants take part in ed…

This observational study looks at whether snack consumption and eating behavior are linked to the severity of ADHD in children aged 6 to 12. Researchers will survey children with ADHD and a control group about their eating habits and snack choices. The goal is to understand if ce…

This study investigates whether one year of boxing training can improve attention in adolescent athletes aged 13-15. Researchers will use the Attention Network Test to measure changes in alerting, orienting, and executive control. The goal is to understand how boxing affects brai…

This study explores whether a full English course built on the DeepSeek artificial intelligence platform can improve orthopedic nurses' professional English skills. Twenty nurses will take an 11-week blended online and offline course covering topics like trauma nursing, joint rep…

This study looks at how common heart problems are in children with ADHD. Researchers will compare 50 children with ADHD who take medication to 50 healthy children. They will use ECG and echocardiograms to check for heart issues.

This study tests whether a simple, non-invasive brain test (EEG) can predict which of two common ADHD medications—methylphenidate or amphetamines—works best for a child. About 220 children aged 7-11 with ADHD will try both medicines in a random order over 7 weeks. The goal is to …

This study looks at whether drinking caffeinated coffee helps professional chess players think faster and make better moves during tournament games. Twelve top-level players (rated 2300-2600 Elo) will play chess after drinking either regular coffee or decaf, without knowing which…

This study will check how often people with ADHD also have fibromyalgia, and vice versa. Researchers will collect blood and urine samples from 100 adults to look for shared biological markers. The goal is to better understand why these two conditions often occur together.

This study looks at how the brain works in 200 children with hard-to-treat epilepsy who are already scheduled for brain monitoring. Researchers will measure brain activity during tasks like learning and decision-making. The goal is to better understand thinking and memory, which …

This study will develop and test an online training program for nurses who give powerful cancer drugs like chemotherapy. About 238 nurses from two cancer centers in Oman will take part. Half will get the e-learning course, and half will continue with usual training. Researchers w…

This study aims to create a therapy program using Acceptance and Commitment Therapy (ACT) for fathers of children with special needs in Hong Kong. Researchers will interview 20 fathers and social workers to understand their challenges and what kind of support would help. The goal…

This study interviews people with learning differences and surveys medical students to understand what future doctors need to learn to provide better care. The goal is to use these insights to create volunteer-led teaching sessions. The study is small, with 15 participants, and a…

This study is looking for early clues—like brain activity, genetics, and environment—that might predict autism, ADHD, and related mental health issues in children and young adults. Researchers will follow 800 participants from infancy through young adulthood across 10 internation…

This study examines how person-centered care affects the health and well-being of older adults and staff in academic nursing homes in Sweden. Researchers will survey 600 participants, including residents and staff, over time. The goal is to understand how to make elderly care mor…

This study looks at how often people develop speech or swallowing problems after a jaw-advancement surgery for obstructive sleep apnea. Researchers will measure nasality, speech, and swallowing in 28 adults before and after surgery at five different times. The goal is to better u…

This study will follow 120 Mandarin-speaking children with autism and typically developing children to understand how speech develops over time. Researchers will use parent reports and play sessions to track language skills. The goal is to create models that help predict speech p…

This study will look at sleep in 34 children with Tourette syndrome, comparing them to children without the condition. Researchers will use a special tic index, a watch-like movement tracker, and overnight sleep recordings to see how tics affect sleep quality. The goal is to bett…

This pilot study will test whether eye-tracking and balance tests can help identify early signs of ADHD in children aged 3 to 5. Researchers will compare 30 children with ADHD symptoms to 30 healthy children of the same age. The goal is to develop a platform for earlier detection…

This study will look at balance, posture, and fine motor skills in 38 children aged 6–18 who have specific learning disabilities. Researchers will use simple tests like standing on a balance beam and picking up small objects. The goal is to better understand the motor challenges …

This study watches real conversations between healthcare staff and people with dementia after hip fracture surgery. The goal is to find which words and phrases work best to encourage patients to stand or walk early. Researchers will record up to 50 care sessions on hospital wards…

This study looks at whether children with ADHD have different levels of inflammation and nutrition markers compared to children without ADHD. Researchers will follow 80 children aged 7 to 17 for one year to see if these markers affect how well they respond to common ADHD medicati…

This study will compare how well an AI program (Blings) measures speech clarity in 40 adults with speech disorders from stroke or other neurological conditions. Two speech therapists will also rate the same speech samples. The goal is to see if the AI can reliably replace or assi…

This study will check how much psychiatric clients know about occupational therapy (OT) and whether their expectations are realistic. It will also evaluate how well OT interns explain health information and conduct interviews. Researchers will develop new tools to measure these s…

This study aims to create a system to assess and improve motor skills in children aged 4 to 12 with neurodevelopmental disorders like ADHD. Researchers will test different exercise programs to see which ones best help these children move better and think more clearly. The goal is…

This study will test whether using a metaverse environment with virtual patients helps nursing students improve their communication skills, stay engaged in learning, and reduce daydreaming. One hundred fourth-year nursing students will be randomly assigned to either metaverse tra…

This study tests a culturally adapted home program for Arab toddlers in Israel. 240 families with children aged 18-36 months will receive either eight weekly sessions teaching parents how to boost language and problem-solving through play and routines, or eight sessions on genera…

This observational study will look at 185 children with epilepsy to find out how many also have ADHD symptoms. Researchers will track changes in ADHD symptoms and quality of life over 12 weeks. The goal is to identify risk factors and understand how ADHD affects epilepsy outcomes…

This observational study will examine the results of genetic testing (karyotyping) in 75 children aged 1 month to 12 years who have both birth defects and developmental delays. Researchers will collect medical histories, perform physical exams, and analyze genetic test results to…

This study tests a training program where pediatricians practice talking about contraception with computer-generated avatars of a teen and her mother. The goal is to see if this boosts doctors' confidence and skills in shared decision-making. The study will enroll 166 medical res…