Magic mushroom compound could help people who stutter
NCT ID NCT07296328
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 2 pilot study will test whether a single high dose of psilocybin (the active ingredient in magic mushrooms) combined with speech therapy can improve fluency and reduce struggle in 25 adults who stutter. Researchers will measure changes in stuttering severity and brain activity. The goal is to see if this approach is safe and worth studying further.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- psilocybin
- What this could lead to
- If it works, this could point toward a new way to reduce stuttering severity and struggle by combining a psychedelic drug with speech therapy.
- What could go wrong
- This is a very small, early pilot study with only 25 people and no placebo group. The results may not apply to everyone who stutters, and psilocybin can cause intense psychological effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
NYU Langone Health
New York, New York, 10016, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Facing the fear: could desensitization training unlock job interview success for people who stutter?
- Brain scans and speech tasks aim to unlock the secrets of stuttering
- Sound waves aim to ease stuttering in early trial
- Brain zaps aim to smooth stuttering speech
- Brain zaps + speech therapy: new hope for stuttering?
- Can rhythm tasks unlock secrets of childhood stuttering?