Can a brain scan predict ADHD drug response?
NCT ID NCT04781972
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study uses brain imaging (fMRI and MRS) to see how a single dose of methylphenidate changes brain activity and glutamate levels in 30 adults with ADHD. Participants will receive both the drug and a placebo in a double-blind crossover design. The goal is to find brain-based markers that could predict who will benefit from methylphenidate, helping to develop better treatments in the future.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
methylphenidate
What this could lead to
If successful, this could help identify brain-based markers that predict who will respond to methylphenidate, potentially guiding more personalized ADHD treatment.
What could go wrong
This is a small, early-phase imaging study with only 30 participants. It measures short-term brain changes after a single dose, not long-term treatment outcomes. Results may not translate to clinical practice.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Johns Hopkins School of Medicine
RECRUITINGBaltimore, Maryland, 21205, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••