Brain zap test may tailor ADHD meds for kids

NCT ID NCT04421248

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study aims to see if two brain measurements taken with Transcranial Magnetic Stimulation (TMS) can help guide ADHD treatment in children aged 8 to 12. Researchers will test these measurements for reliability, how they change with a single dose of methylphenidate (Ritalin), and how they relate to thinking and emotion. The goal is to develop a tool that could lead to more personalized and effective ADHD care.

What this could mean

Our plain-language read of the trial. This is informational only โ€” not medical advice or a prediction.

Active substance
Methylphenidate (Ritalin)
What this could lead to
If successful, this could lead to a brain-based test to help doctors choose the best ADHD treatment for each child, improving outcomes.
What could go wrong
This is an early-phase biomarker study, not a treatment trial. The TMS measures may not reliably predict treatment response, and results may not apply to all children with ADHD.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Cincinnati Children's Hospital Medical Center

    RECRUITING

    Cincinnati, Ohio, 45229, United States

  • Kennedy Krieger Institute

    RECRUITING

    Baltimore, Maryland, 21205, United States

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