Substance dependence

This study tested whether offering hepatitis C (HCV) treatment right at methadone clinics helps more people get cured compared to sending them to outside specialists. Over 600 adults on opioid addiction therapy took part across 13 clinics in Ukraine. Some clinics provided simplif…

Researchers are testing whether two dose combinations of metyrapone and oxazepam can help adults with cocaine addiction. The study enrolls 45 people aged 18 to 50 who want treatment and have cocaine in their system. Participants take the drugs or a placebo twice daily for six wee…

This study tests a structured, 8-week smoking cessation program delivered via weekly video group sessions. It enrolls adults addicted to nicotine who want to quit. Researchers track whether participants stay smoke-free six months after the program ends, and how their anxiety and …

Researchers are testing a Spanish version of CANreduce, a web-based self-help program that uses cognitive behavioral therapy and motivational interviewing to help people reduce their cannabis use. The trial compares three groups: one gets the program plus psychological support, o…

This study tests a program called MIAPP that adds a patient navigator, smartphone check-ins, and small rewards to usual care for people who start buprenorphine for opioid use in the hospital and also use methamphetamine. The goal is to help them connect to outpatient treatment wi…

This study tests different ways to bring mental health treatment into methadone clinics in Ukraine. 1,350 patients from 12 clinics are taking part. Some clinics get extra training and financial rewards to help screen and treat depression. The goal is to see if these strategies im…

This study tested whether giving rewards like gift cards can help Native American women quit smoking and lose weight. 125 women who smoked daily and were overweight or obese took part. They earned prizes for staying smoke-free and losing a half to one pound per week. The goal was…

This study tests whether referring Veterans in early recovery from substance use disorder to work-focused programs (like supported employment) helps them stay sober and function better. About 100 Veterans will be randomly assigned to get the work referral or usual treatment alone…

This study tests whether gabapentin, an FDA-approved medication, can help restore the balance of key brain chemicals (GABA and glutamate) in people with bipolar disorder who also use cannabis. Participants are randomly assigned to receive either gabapentin or a placebo for 17 day…

This trial tests whether regular checkups after release from jail can help people with opioid use disorder stay in treatment. Researchers will compare standard re-entry care with two versions of a Recovery Management Checkups program, one with monthly meetings for three months an…

This study tests a non-invasive brain stimulation technique called targeted temporal interference stimulation (tTIS) aimed at the caudate nucleus. The goal is to reduce drug cravings and improve decision-making in 60 adults with methamphetamine use disorder. Participants will rec…

This study tests a smartphone app called Re-Connect that locks access to fun apps like social media and games. To unlock them, you must pass a breath test showing you haven't smoked recently. Researchers want to see if this reward system is easy to use, acceptable, and helps peop…

This study tested a mobile phone-based wellness program (WISH) to help veterans with HIV quit smoking. 234 participants were split into two groups: one received the WISH program, the other got standard care (quitline and text support). The goal was to see if the wellness program …

This trial tests a digital program designed to help people quit tobacco. Over 2,200 participants will use the program or receive usual care. The main goal is to see if the program helps people stop using their primary tobacco product for at least 30 days.

This study tests whether a rotigotine skin patch (Neupro), already approved for Parkinson's disease, can help people with cocaine use disorder cut back on cocaine use when combined with behavioral therapy. Forty adults aged 25 to 70 with moderate to severe cocaine use disorder wi…

This trial tests whether a monthly injection of extended-release buprenorphine (Sublocade) helps people with opioid use disorder who use fentanyl reduce their opioid use more than the standard daily sublingual buprenorphine pills. Adults aged 18 to 65 with moderate to severe opio…

This study tests a refined computer alert that prompts emergency room doctors to order a consultation with an addiction counselor for patients with opioid use disorder. Researchers will enroll 300 adults with moderate to severe opioid use disorder who visit the ER. The goal is to…

This study tests whether a smartphone app can help people with opioid use disorder stay drug-free. Participants use the app to submit video-recorded saliva drug tests, earn rewards for staying abstinent, complete therapy modules, and get support from a peer. The study involves 25…

This study looked at whether e-cigarettes or nicotine lozenges help people on methadone switch from smoking tobacco. 183 smokers were randomly assigned to use either JUUL e-cigarettes or nicotine lozenges for 6 weeks. Researchers measured nicotine exposure, lung function, and smo…

This early-phase study tested whether adding a medication called Auvelity (a combination of dextromethorphan and bupropion) to standard buprenorphine treatment is safe and might help reduce cravings, withdrawal, and negative feelings in people with opioid use disorder. 18 adults …

This study tests whether an app that gives financial rewards for drug-negative saliva tests works for older adults with opioid, cocaine, or methamphetamine use disorder. Researchers will compare results between older and younger participants to see if age affects how well the app…

This trial tests whether guanfacine-ER, a medication currently used for ADHD, can help people with cannabis use disorder reduce their cannabis use. Participants will receive either guanfacine-ER or a placebo daily for several weeks, and their cannabis use will be tracked through …

This study tests whether the nicotine concentration in vape pods affects how well smokers can quit. 312 adult smokers who want to quit will use either low or high nicotine salt e-liquids for three months, plus receive counseling. The goal is to see if higher nicotine levels lead …

This trial tests whether letting smokers adjust their own nicotine patch dose—based on their smoking history and withdrawal symptoms—helps them stay smoke-free longer than the standard fixed-dose patch. Adult smokers who smoke at least 10 cigarettes a day and are motivated to qui…

This trial tests whether a 'learning health system'—a structured partnership between juvenile justice agencies and community mental health centers—can improve the full continuum of substance use care for youth involved in the justice system. The approach uses local data to identi…

This study tested a remote video monitoring system to help people with opioid use disorder safely take their methadone at home. Fifteen adults already on methadone treatment used a smartphone or computer camera to record each dose. The goal was to see if this method could track a…

This pilot study tests whether combining ketamine injections with talk therapy is a safe and acceptable way to treat moderate-to-severe methamphetamine use disorder in 17 publicly insured patients, some of whom have or are at risk for HIV. Participants receive three monitored ket…

This study tested whether N-acetylcysteine (NAC), an over-the-counter supplement, can help people who use both tobacco and cannabis quit both substances. Fifty-nine regular smokers who also used cannabis took either NAC or a placebo for 8 weeks. Researchers tracked how often they…

This study tests whether adding the sleep medication suvorexant to standard buprenorphine treatment can improve sleep and medication adherence in people with opioid use disorder who have recently used fentanyl. Participants first stay in a residential setting for five days to sta…

This trial tests whether video-based teleconsultation counseling can help people stop smoking as effectively as traditional face-to-face clinic visits. About 68 adults who smoke will receive either teleconsultation or in-person counseling, with researchers tracking quit rates, cr…

This study tests a staged approach to help addiction treatment programs in Washington State increase their use of medications for opioid use disorder (MOUD). Clinics start with simple feedback reports and, if needed, move to more intensive support like workshops and coaching. The…

This study tests whether offering financial incentives through a mobile phone app can help low-income adults quit smoking. 532 participants will receive either standard care (phone counseling and nicotine patches/gum) or standard care plus mobile rewards for verified abstinence. …

This trial uses brain scans to see whether 8 weeks of mindfulness-based group therapy changes how the brain processes reward, craving, and self-control in people with heroin addiction. About 157 adults on medication for opioid use disorder will be randomly assigned to mindfulness…

This study tests whether a virtual reality program, based on the transtheoretical model of behavior change, can help university students quit smoking. Participants will use VR goggles to practice coping skills in realistic scenarios. The goal is to see if this training boosts the…

This study tests a home-based parenting program called BRIGHT for pregnant women receiving treatment for opioid use disorder. The program starts in the third trimester and continues for six months after birth, focusing on the parent-child relationship, mental health, and infant d…

This study tests a smoking cessation program designed for adults with serious mental illness. Participants receive a combination of videogame-based physical activity, smoking cessation counseling, and the medication bupropion. The goal is to see if this approach is feasible and a…

This study tests two approaches to help people recently involved with the justice system start HIV prevention or treatment and substance use care. One group gets standard patient navigation; the other can choose from a menu of services including in-person clinics, a mobile health…

This study tests a care model where hospitalized adults with opioid use disorder and a serious infection receive long-acting injectable buprenorphine from their infectious disease doctors, alongside infection treatment. The goal is to keep patients on effective medication for opi…

This study tests a mobile app called KIOS that gives personalized advice and support to people receiving medication-assisted treatment for opioid use disorder. Over 12 weeks, 116 participants will either use the app plus standard counseling or just standard counseling. The goal i…

This study tested whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can reduce methamphetamine use in people already receiving methadone maintenance therapy. Fifty-five adults with both opioid and methamphetamine use dis…

This study tests whether offering peer support, small incentives, telehealth visits, or prepaid phones helps people with hepatitis C and substance use disorders get linked to medical care. Participants are adults in Appalachia who have tested positive for hepatitis C and have a h…

This study tests a text-message-based cognitive behavioral therapy (CBT) program called imFREE to help adults with opioid use disorder stick with their buprenorphine treatment and reduce opioid use. Participants receive daily text messages with CBT skills and relapse prevention t…

This study tests a 6-week group program called Indigenous Recovery Planning (IRP) for American Indian adults with alcohol or drug use disorder. The program is led by trained community members and includes culturally adapted exercises to prevent relapse. Researchers want to see if…

This study tested a treatment called CPT-SMART that combines PTSD therapy, smoking cessation counseling, medication, and financial incentives to help veterans quit smoking. 120 veteran smokers with PTSD were randomly assigned to either the full program or a control group. The goa…

This study tested a program to help people with opioid use disorder stay on their medication after being hospitalized for serious infections like endocarditis or bone infections. Forty adults took part to see if the program was practical and helpful. The goal is to improve long-t…

This study tests a small ear device that gently stimulates nerves to see if it helps people with both PTSD and opioid use disorder stay on buprenorphine therapy. Twenty participants will use either the active device or a placebo for 12 weeks. Researchers will check if they keep t…

This study tested whether offering smokers more frequent and personalized outreach, plus more treatment choices like nicotine patches and text support, helps more people quit compared to standard care. Over 12,000 adult smokers from 10 primary care clinics took part. The goal was…

This study tested whether giving buprenorphine treatment in group medical visits (instead of one-on-one) helps people with opioid use disorder stay abstinent and remain in treatment. Eighteen adults already on buprenorphine but still using opioids took part in weekly 90-minute gr…

This completed trial tested a new approach for opioid use disorder: shining a specific type of near-infrared light on the scalp for just 4 minutes. The idea is to stimulate a healthier side of the brain to reduce addiction. Researchers compared the active light treatment to a sha…

This study tested whether text message reminders and rewards could help people who smoke to stick with their quitline counseling and take their medication. Twenty adults who smoked daily took part. They received a prescription for a stop-smoking drug and were referred to a quitli…

This study tested whether offering small gift cards for quitting smoking helps low-income smokers stay smoke-free. 320 uninsured or Medicaid patients received either standard care (counseling and medication) or standard care plus financial rewards for verified abstinence. The mai…

This study tested different ways to help daily smokers quit by comparing two medications (varenicline and nicotine patches/lozenges), how long to take them before quitting, how long to continue after quitting, and the level of counseling. Over 500 smokers from primary care partic…

This phase 2 trial tested whether cannabidiol (CBD) can reduce craving and anxiety in 76 adults with opioid use disorder who were already on opioid agonist therapy (like methadone). Participants took CBD or a placebo twice daily for 4 weeks, then all took a higher dose of CBD for…

This study tests whether measuring tobacco smoke exposure in children, using a simple blood test, can help parents quit smoking. About 865 parents of young children (12 or younger) who smoke will be enrolled. The goal is to see if this approach, combined with support, leads to mo…

This study tests whether a 15-week aerobic exercise program at the YMCA can help smokers who are highly sensitive to stress quit smoking. Participants work with a personal trainer three times a week and also receive support from a national quitline. The goal is to see if exercise…

This study tested whether a mobile health unit that offers HIV prevention, treatment, and medication for opioid use disorder all in one place helps people who inject drugs stay on treatment. About 447 adults with opioid use disorder took part. The goal was to see if this approach…

This trial tests whether a team-based approach, including a dedicated nurse care manager, can help primary care clinics provide medication treatment for opioid use disorder. The study involves 12 clinics across five U.S. states, with half using the new approach and half continuin…

This study tested a device called the Bridge, which uses mild electrical pulses to ease opioid withdrawal symptoms. 36 adults with opioid addiction were randomly assigned to get the active device, withdrawal medication (lofexidine), or a placebo. The goal was to see if the device…

This study tested whether a once-monthly injection of buprenorphine works as well as daily pills to treat opioid use disorder in 140 pregnant women. The goal was to see if the monthly shot could reduce illicit opioid use during pregnancy and after birth. Results help doctors choo…

This study tested two different approaches to help people recently released from jail or prison get connected to care for HIV, hepatitis C, STIs, and opioid use disorder. Over 600 adults took part. The goal was to see which method worked better for starting and staying on treatme…

This study tested three different ways to help people living with HIV stop smoking. Over 670 patients from 13 HIV clinics in Hanoi took part. Nurses either referred patients to a quitline, provided counseling, or offered counseling plus nicotine gum. The goal was to see which met…

This study looked at different ways to help people with opioid use disorder start treatment. It compared usual care, patient navigation (help from a guide), and patient navigation plus starting buprenorphine right away. The goal was to see which approach gets more people into tre…

This study looked at whether giving a special research e-cigarette to people who are stable on medication for opioid use disorder and smoke daily could help them smoke fewer regular cigarettes. 41 adults who weren't ready to quit smoking were randomly assigned to get the e-cigare…

This study looked at whether adult smokers who switch to heated tobacco products have lower levels of harmful chemicals in their bodies compared to those who keep smoking regular cigarettes. Over 900 healthy smokers aged 22 to 65 took part. Researchers measured various biomarkers…

This study tested a web-based addiction treatment program that was culturally adapted for American Indians and Alaska Natives. 53 adults in outpatient treatment used the program for 12 weeks. The goal was to see if it helped them stay away from drugs and alcohol and to decide if …

This study tested whether offering medication for opioid use disorder (MOUD) via telehealth to women in jail helps them start treatment after release. 900 women across 9 Kentucky jails took part. Some also got a peer navigator for support. The goal was to see if these services in…

This study tested whether psilocybin, the active ingredient in magic mushrooms, could help people reduce or stop using cocaine. Forty adults who wanted to quit cocaine were given either psilocybin or a placebo (diphenhydramine, an antihistamine) in a controlled setting. Researche…

This study tested whether giving pregnant smokers cigarettes with very low nicotine (0.4 mg per gram of tobacco) helps them smoke less over 12 weeks. Thirty women were randomly assigned to either their usual brand or the low-nicotine cigarettes. The main goal was to see if they s…

This study tested whether offering financial incentives through a smartphone app could help pregnant women stop smoking. 150 women who smoked were randomly assigned to either earn rewards for submitting breath and saliva tests showing no smoking, or to receive standard care. The …

This study tested a program called the Transitions Clinic Network (TCN) for people leaving jail with opioid addiction. The program combines primary care, medication options, and a community health worker to address social needs. Researchers compared this to standard care and foll…

This study tested a smartphone app called TECH designed to help court-involved teens reduce or stop using marijuana. The app is a private online community where teens can support each other anonymously. Researchers enrolled 60 teens aged 14-18 who had used marijuana in the past y…

This early-stage study tested a new implant that slowly releases naltrexone, a medication used to treat opioid use disorder. The implant is placed under the skin and left for three months. The trial involved 16 healthy adults to check safety and how the drug enters the bloodstrea…

This study tested whether a once-monthly injection (XR-BUP) works as well as daily pills (SL-BUP) for treating opioid use disorder in rural settings. 140 adults with moderate to severe opioid use disorder took part. The goal was to see if the injection is practical and acceptable…

This study tested whether people with opioid use disorder and severe injection-related infections can be safely treated at home with antibiotics and buprenorphine (a medication for opioid use disorder). 71 participants were enrolled. The goal was to see if this integrated approac…

This study tested whether adding a support person—like a family member or friend—to standard buprenorphine treatment helps people with opioid addiction stay in treatment longer. 439 patients and their support persons took part. The support persons learned CRAFT, a counseling prog…

This completed phase 4 pilot trial tested whether varenicline (Chantix) works better than nicotine patches and lozenges for helping smokers quit. Over 600 smokers who smoked at least 5 cigarettes daily took part. The study measured how many people stayed smoke-free for 7 days, ve…

This early-stage trial tested whether a drug called STP7 (mavoglurant) can safely reduce the physical and psychological effects of cocaine in 21 adults who use cocaine but are not seeking treatment. Participants received either STP7 or a placebo, then were given intravenous cocai…

This study tested whether giving people with alcohol dependence a one-month course of diazepam (40 mg per day) after detoxification could reduce the chance of relapsing into drinking within the next three months. The standard detoxification treatment is usually about one week. Th…

This study tested whether cannabidiol (CBD) can reduce cravings and prevent relapse in people with opioid use disorder who are already taking standard medications like buprenorphine or methadone. Thirty-five participants received either CBD or a placebo for 28 days while in resid…

This study looked at whether switching from regular cigarettes to either low or high wattage e-cigarettes changes smoking behavior and reduces exposure to harmful chemicals. 372 daily smokers who were not planning to quit were given e-cigarettes to use freely for 12 weeks, then c…

This study tested a smartphone app designed specifically for women to help them stay engaged with their medication for opioid use disorder. 39 women who had recently started medication treatment were randomly assigned to use the app plus standard care, or standard care alone. Res…

This study tested a comprehensive program to help women involved in the criminal justice system start and stay in opioid addiction treatment. The program included peer support, housing help, overdose training, and transportation or childcare. Half of the 42 women also joined a tr…

This study tested whether a pharmacist-led program could help people leaving jail get treatment for opioid use disorder and prevent overdoses. Participants received overdose training, Narcan nasal spray, counseling, and referrals to medication treatment after release. The goal wa…

This study tested a collaborative care model for people with opioid use disorder and depression, anxiety, or PTSD. 567 adults received medication (buprenorphine-naloxone or naltrexone) along with therapy and support from a primary care team. The goal was to reduce opioid use and …

This study tested a mobile app (uMAT-R) designed to help pregnant and postpartum women with opioid use disorder stay on their medication and treatment. 125 women participated in a pilot trial to see if the app was easy to use and helped reduce cravings and improve attitudes towar…

This study tested a 12-month telephone-based nurse care program for 805 adults with depression and signs of opioid use disorder. Participants were randomly assigned to receive nurse support or usual care. The goal was to see if the program could improve treatment for opioid use a…

This study tested whether adding mindfulness-based relapse prevention (MBRP) to standard care helps people with opioid use disorder stay on their medication (extended-release naltrexone) and avoid drug use after leaving a residential treatment program. About 105 participants were…

This early-stage study tested whether a brief therapy program plus a mobile app could help pregnant and postpartum women stay on their buprenorphine medication for opioid use disorder. Fifteen pregnant women took part, attending therapy sessions and using the app for up to 9 mont…

This study tested two long-acting injectable medications, aripiprazole and paliperidone, in 165 people who use stimulants and have psychosis. The goal was to see if these drugs could better manage psychosis and prevent progression to chronic schizophrenia compared to standard tre…

This study tested a program called RIMO that helps people who recently survived an opioid overdose get into medication-assisted treatment (MAT). The program uses motivational interviewing and support to encourage people to start and stay on MAT. Researchers worked with first resp…

This completed Phase 4 trial tested a new way to start oral opioid addiction therapy for people who use fentanyl. Participants received medically supervised IV fentanyl until comfortable, then were given tailored doses of methadone or slow-release oral morphine. The study enrolle…

This study tested a new injectable medication called INDV-6001 in 123 adults with moderate to severe opioid use disorder. The goal was to see how the drug moves through the body, if it is safe, and how well people tolerate it. Participants received multiple doses, and researchers…

This study tested whether giving adults with chronic pain discounted vouchers for medical cannabis soft-gel capsules could help them reduce their opioid painkiller use. 270 participants were randomly assigned to receive vouchers for placebo or cannabis capsules with different THC…

This pilot study tested a program called 'Nudges to Quit' that sends encouraging messages to people with serious mental illness who smoke. The goal was to see if these messages could help them start smoking cessation treatments like counseling or medication. The study involved 59…

This completed study tested deep brain stimulation (DBS) in just one person with severe, treatment-resistant opioid use disorder. The goal was to see if stimulating brain reward areas could reduce opioid use and improve safety. Because only one participant was enrolled, the resul…

This study looked at whether giving doctors a simple urine drug test in their office helps people stay on buprenorphine treatment for opiate addiction. About 42 patients starting buprenorphine with their family doctor took part. The goal was to see if these tests improve treatmen…

This study tested a simple, low-cost program to help adults stop using tobacco in busy community health centers in Mumbai, India. Nearly 4,700 participants received either brief advice from trained health workers or usual care. The program used a mobile app and WhatsApp to suppor…

This study tested whether a smartphone app designed for people with serious mental illness can help them quit smoking better than standard methods. Researchers enrolled 343 adults with conditions like bipolar disorder or schizophrenia who wanted to quit. Participants used either …

QuitBet is a digital social game that helps people stop smoking by letting them bet $30 of their own money. Players submit daily breath tests to prove they haven't smoked. Those who succeed split the pot of money from those who fail. This study tested QuitBet in 245 adults who sm…

This pilot study tested a program where trained peer recovery specialists meet regularly with patients starting medication for opioid use disorder. The goal was to see if the program is practical and acceptable to patients. 13 adults took part, and the results will help design a …

This study compared four different smoking cessation programs to see which one works best for underserved smokers who are getting lung cancer screening. Over 3,200 participants from four U.S. health systems took part. The goal was to help them quit smoking for at least six months…

This study tested a mobile app designed to help nursing students who smoke change their attitudes and reduce their smoking. Forty-three students used the app, which sent reminders and educational content. Researchers measured changes in smoking intention, attitudes, and decision-…

This study looked at whether smokers who want to cut down can switch to a special research e-cigarette and smoke fewer regular cigarettes. Over 12 weeks, researchers tracked how many cigarettes people smoked and if any quit completely. The goal was to see if e-cigarettes are a he…

This study tested a program called CareConnect that uses automated phone calls to help cancer patients stop smoking. About 400 cancer patients who smoked took part. The program gave them educational messages and connected them to resources like quitlines or websites. The goal was…

This study looked at whether smokers who quickly respond to nicotine alternatives (like patches, e-cigarettes, or pouches) can keep smoking less or stop entirely for 6 months. 150 healthy adult smokers who reduced their smoking by at least half within 2 weeks were followed. The g…

This study tested two different doses (100 mg vs 300 mg) of a monthly buprenorphine injection in 785 adults with moderate to severe opioid use disorder. The goal was to see which dose helped people stay in treatment and reduce opioid use. The study also compared a faster versus s…

This study looked at whether adding computer-based cognitive behavioral therapy (CBT4CBT) and peer recovery coaching to standard buprenorphine treatment helps reduce illicit drug use. 92 adults with opioid use disorder were randomly assigned to receive buprenorphine alone, bupren…

This study looked at 240 prisoners with opioid addiction to see if getting a long-acting naltrexone shot at home after release works better than going to a clinic. Participants got one shot in prison and six monthly shots either at a clinic or at their home. The goal was to see i…

This study tested whether ibudilast, a drug that reduces brain inflammation, can help people addicted to methamphetamine. 176 participants took either ibudilast or a placebo for 6 weeks. Researchers used brain scans and thinking tests to see if the drug improved brain function an…

This study tested an enhanced tobacco cessation program for retired FDNY firefighters who smoke. The program automatically enrolled participants in counseling, tailored the advice based on their lung scans and breathing tests, and started a quit-smoking medication (varenicline) e…

This study tested different combinations of counseling, rewards, and text reminders to help people on methadone therapy reduce methamphetamine use and improve HIV outcomes. 667 participants from methadone clinics in Vietnam took part. The goal was to find the best approach to sup…

This study tested whether a low dose of cariprazine, a medication used for bipolar disorder, could help people with both opioid and cocaine use disorders reduce cocaine use. Participants were already stable on buprenorphine-naloxone for opioid use. The trial lasted about 11 weeks…

This small pilot study tested whether a type of brain stimulation called transcranial magnetic stimulation (TMS) could help people with methamphetamine use disorder. Nineteen participants received daily TMS sessions for two weeks, then three times a week for two more weeks, while…

This study tested a pill called cytisinicline, made from a plant compound, to see if it helps adults stop using nicotine e-cigarettes. 160 daily vapers took either the drug or a placebo for 12 weeks, along with brief counseling. The main goal was to see if more people could quit …

This pilot study looked at whether giving free e-cigarettes to smokers who hadn't quit after lung cancer screening could help them smoke fewer regular cigarettes. Fifteen people who smoked at least 5 cigarettes a day were given NJOY ACE e-cigarettes for 4 weeks and asked to switc…

This study tested a mindfulness program designed for women in residential treatment for substance use disorders. The program, called Mindfulness-Based Relapse Prevention for Women (MBRP-W), teaches stress management skills to help women stay in treatment and avoid relapse. Resear…

This study tested a smartphone app that combines therapy, brain training, and rewards to help people with methamphetamine addiction. 360 adults in community rehab used the app or received standard care. The main goal was to see if the app could reduce cravings triggered by drug-r…

This study tested different ways to help people living with HIV quit smoking. Participants received nicotine replacement therapy (like patches or gum), the medications varenicline or bupropion, and financial rewards for staying smoke-free. The goal was to see if these approaches …

This study tested whether peer recovery coaches in emergency departments can help people with substance use disorders connect to treatment and support. 144 adults were randomly assigned to get in-person coaching, coaching via video call, or just a list of resources. Researchers f…

This study looked at whether giving buprenorphine treatment directly at syringe exchange programs helps people with opioid addiction more than sending them to a community health center. About 100 syringe exchange participants in New York City took part. The goal was to see if sta…

This study tested whether a once-monthly injection of extended-release buprenorphine helps hospitalized patients with moderate to severe opioid use disorder stay in treatment better than usual care (like daily pills or methadone). Over 300 adults were randomly assigned to receive…

This study tested a program to help people with mental illness quit smoking. The program included brief advice from their mental health provider and phone calls offering support. Researchers enrolled 94 daily smokers from community mental health centers and measured how many quit…

This study tested a personalized approach to help people quit smoking by matching medication to their nicotine metabolism. 606 adults on Medicaid or Medicare who smoked daily took part. The goal was to see if tailoring treatment improves quit rates.

This pilot study tested two behavioral programs to help people with opioid use disorder take their medication as prescribed. One group could win gift cards when their urine tests showed they were taking their medicine. The other group had one-on-one sessions to set goals, find fu…

This study tested a computer program called C-Raven that uses an interactive avatar to help people quit smoking. Participants used an iPad for two 20-minute sessions and could get nicotine replacement therapy and support from a community health worker. The study was small (18 peo…

This study tested a telephone program called Be Smoke Free that uses guided imagery (a relaxation technique) to help people stop smoking. Over 1,200 daily smokers from Arizona, New York, and West Virginia took part. Participants received coaching calls and were checked at 3 and 6…

This study tested whether delivering pre-made meals to the homes of people in treatment for opioid use disorder could help with food insecurity. Fifty adults were split into two groups: one got nutrition education and community resources, while the other also received weekly meal…

This study tested a program that provides dedicated care navigation to people with methamphetamine use disorder. The goal was to help them enter and stay in addiction treatment, and to prevent overdoses. 192 adults from the Denver Health system who had a methamphetamine-related v…

This study tested whether training people on methadone to become peer educators could help their friends who inject drugs and have HIV get into treatment. The peer educators talked to their social network members about medication for drug dependence and accompanied them to the cl…

This study tested whether topiramate, a seizure medication, can help people who are dependent on both alcohol and nicotine. 236 adults received either a low or high dose of topiramate or a placebo, plus behavioral therapy. The goal was to see if the drug could reduce heavy drinki…

This study tested whether a trained peer recovery specialist could help low-income, minority individuals stick with their methadone treatment for opioid use disorder. 200 participants in Baltimore were assigned to either the peer-led support program or standard care. The goal was…

This study tested whether a combination of two extended-release medications (naltrexone and buprenorphine) could help adults reduce cocaine use. Over 400 people who wanted to cut back or quit cocaine took part. The approach uses monthly injections to manage cravings and use, aimi…

This pilot study tested a telehealth platform designed to encourage people with opioid use disorder to start and stay on medication treatment. 33 participants with a history of opioid overdose used the platform, which included chat-based support. The study measured whether they a…

This study tested whether a team-based care model can help people with both opioid use disorder and mental health issues like depression or anxiety. 254 adults in primary care received either full collaborative care for both conditions or just mental health support. The goal was …

This study tested a smartphone-based program that uses rewards, coaching, and breathalyzer tests to help 236 adults with alcohol use disorder reduce drinking. Participants earned money for staying sober, tracked via breath tests and self-reports. The goal was to see if this digit…

This study tested whether combining a brain stimulation technique called theta burst stimulation (TBS) with the medication N-acetylcysteine (NAC) could reduce cocaine cravings and brain responses to cocaine-related images. Thirty-two adults with cocaine use disorder participated.…

This study tested a digital pill and smartphone app to help people with substance use disorders take their HIV prevention medication (PrEP) consistently. Thirty HIV-negative men who have sex with men and have moderate to severe substance use disorder participated. They used a dig…

This study tested whether offering hepatitis C treatment at the same clinic where people receive opioid therapy leads to better outcomes than referring them to a separate infectious disease clinic. About 298 people on opioid therapy with chronic hepatitis C took part. The goal wa…

This pilot study tested a counseling program called the Teen Marijuana Check Up, adapted for young adults (ages 13–35) who have early psychosis and use cannabis. The program uses motivational interviewing and personalized feedback over two sessions to help participants reduce or …

This study tests whether a wearable home sleep apnea device called WatchPAT200 can accurately detect central sleep apnea in people who take narcotic medications. Participants wear the device during an overnight lab sleep study, and results are compared to the standard in-lab test…

About 25% of people who have knee replacement surgery develop persistent pain that can last for months. This trial tests whether taking a CBD-dominant oil before and after surgery can reduce that risk. Researchers will randomly assign about 40 adults to receive either CBD oil or …

Researchers are testing whether a four-week group program can help people who inject drugs and are in methadone treatment reduce their risk of HIV. The program teaches skills like cleaning needles and using condoms, and it is compared with a support group that does not focus on t…

This study tested new ways to prevent opioid misuse and addiction in teens and young adults (ages 16-30) who visited the emergency department. Participants received support starting in the ER and continuing through telehealth after they went home. The goal was to find the most ef…

This study tested a simple checklist and peer coaching program for people who inject drugs and are hospitalized with serious infections. The goal was to see if these tools could help start HIV prevention medication (PrEP) and addiction treatment. Sixty HIV-negative adults with op…

This study tested whether a lifestyle physical activity program, using a Fitbit tracker and coaching calls, could help pregnant women at risk for cannabis use reduce their use. Sixteen women who used cannabis at least weekly before pregnancy and had mild depression or anxiety too…

This trial tests whether a comprehensive, community-wide strategy can reduce opioid overdose deaths by 40% in 67 communities hardest hit by the crisis. The approach, called Communities That HEAL, brings together local leaders, healthcare, justice, and community groups to implemen…

This trial tests a school-based curriculum called Smart Talk, designed to reduce cannabis use and intentions among middle and high school students. Over five lessons, the program targets misperceptions, refusal skills, stress, and coping. Researchers will measure whether students…

This study tested a program called TACUNA plus Wellness Circle, designed to prevent opioid misuse among American Indian and Alaska Native young adults aged 18-25 in California. The program uses motivational interviewing and traditional practices in virtual workshops. Researchers …

This study tested a digital program designed to prevent teens from starting to misuse opioids. About 533 high school students who had never misused opioids but were at higher risk took part. The program aimed to increase their understanding of the serious risks of misusing prescr…

This study tested a program called PRE-FAIR to prevent opioid and methamphetamine addiction in young parents (ages 16-30) already involved with Oregon's child welfare system. 240 parents who were at risk but not yet addicted were randomly assigned to either the PRE-FAIR program o…

This study looked at whether omega-3 supplements (fish oil) could help pregnant women who smoke have healthier pregnancies and possibly smoke less. About 237 pregnant smokers took either omega-3 pills or a placebo. The goal was to see if the supplements could reduce preterm labor…

This early-phase study tested whether a hormone called progesterone could help new mothers avoid returning to methamphetamine use after childbirth. 34 postpartum women with a history of meth use but currently abstinent took either progesterone or a placebo for 12 weeks. The goal …

This study tested a smartphone app designed to help people recovering from alcohol dependence avoid relapse. The app uses a training game to change unconscious habits that make people reach for alcohol. 600 participants used either the active training or a placebo version. The go…

This study tested whether text message reminders can encourage people to keep their opioid pain medication in a safe place and throw away any leftover pills after treatment. About 479 adults who received an opioid prescription took part. The goal was to reduce the chance of these…

This study tested a 45-minute classroom program called UP2UTobacco for 9th graders. The goal was to help students quit or avoid tobacco and nicotine products, including e-cigarettes. Nearly 600 students took part, and researchers checked if the program led to more teens being tob…

This study tested whether anti-vaping and anti-smoking ads on social media can prevent tobacco use in young adults ages 18-24. Researchers randomly assigned 2,800 participants to see different amounts of digital ads and measured their vaping and smoking habits over 30 days. The g…

This completed trial tested two school-based programs—Connect and CMCA—to prevent drug and alcohol misuse among 10th graders in rural Cherokee Nation high schools. Over 900 students from 20 schools participated, with some schools receiving the programs and others serving as contr…

This study tested a pop-up clinic inside a van for women who inject drugs and exchange sex in north Seattle. The goal was to see if offering HIV prevention pills, addiction medications, and quick STI testing in a convenient location would help more women start and stay on these t…

This small pilot study tested an 8-week mindfulness and meditation program in 3 adults with substance use disorders. Participants reported lower stress and improved mindfulness after the program. One person stayed sober long-term, while two relapsed within a year. The study shows…

Researchers at Yale University developed a virtual reality game called Invite Only VR to help middle school students learn about the risks of vaping nicotine and cannabis. In the game, players practice refusing offers to vape in realistic social situations. The study tested the g…

This study tested an online parenting program called Family Check-Up Online for rural families where a parent may misuse opioids. 356 parents of young children (18 months to 5 years) took part. The program aimed to improve parenting skills, reduce stress and depression, and preve…

This study tested whether giving homeless young people (ages 18-24) a place to live plus support services could help them avoid developing opioid use disorder. 240 participants who were homeless but did not yet have opioid addiction were randomly assigned to receive either housin…

This pilot study is testing a smartphone app called Mindful Journey that teaches mindfulness skills. The goal is to see if it is practical and acceptable for adults who are in treatment for opioid use disorder and also have chronic pain. Ten participants will use the app for 8 we…

Researchers at a smoking cessation clinic in Turkey tested whether adding WhatsApp messages to routine care helps people stop smoking. Adults who smoked at least one cigarette a day and used WhatsApp most days joined the study. Everyone received standard clinic support, and half …

Researchers at Hanoi Medical University are studying whether methadone clinics can effectively screen, treat, and keep people with methamphetamine use disorder in care. The trial enrolls 60 adults who test positive for meth but not opioids. Participants receive counseling and inc…

This study tested whether a non-invasive brain stimulation technique called theta burst stimulation (TBS) could help reduce cravings and improve symptoms in people with methamphetamine use disorder. Twenty-two adults in Indonesia who had not yet received treatment were given TBS …

This study tested whether a virtual reality experience where people see an avatar of their future self could help those in early recovery from opioid use disorder reduce drug use and stay abstinent. 104 participants were split into a VR group and a control group. Researchers meas…

This study tests a smartphone app that sends personalized messages to help people quit smoking. The messages are triggered by real-time data like location and stress levels, offering coping strategies when urges strike. Seven participants will use the app for 45 days to see if it…

This study tested whether providing overnight infant care and parenting support helps new mothers with substance use disorder living in residential treatment programs. 41 mothers participated, and researchers measured how many enrolled, completed the program, and gave feedback. T…

This study tests whether a buprenorphine patch can reduce withdrawal symptoms when pregnant women with opioid use disorder start sublingual buprenorphine treatment. Forty participants will receive either a real patch or a sham bandage during the initial withdrawal period. Researc…

This study tests whether adding trauma-informed coping strategies and peer coaching to a standard mobile brief intervention helps young adults (ages 18-25) who drink heavily and have experienced interpersonal trauma reduce their alcohol use. 225 college students will be randomly …

This study looks at whether a combination of over-the-counter pain relievers (like ibuprofen and acetaminophen) can control pain after wisdom tooth removal just as well as, or better than, prescription opioids. About 1,800 people having their wisdom teeth removed will be randomly…

This study looked at whether a sleep medication called suvorexant can improve sleep and reduce stress in people recovering from opioid addiction. About 138 participants on medications like methadone or buprenorphine were given either suvorexant or a placebo for 8 weeks. The goal …

This study tested two types of nerve blocks (erector spinae plane block and serratus anterior plane block) to see which provides better pain relief after breast reduction surgery. 80 women received one of the two blocks, and researchers measured how much pain medication they need…

This trial tests whether an educational video shown through virtual reality (VR) glasses and a mobile app can help breastfeeding mothers stop smoking. About 76 mothers with babies aged 0-6 months who smoke will be randomly assigned to either watch the VR and app-based education o…

This study tested a brain stimulation technique called closed-loop tACS in 21 people with methamphetamine addiction. The device uses brain wave patterns to deliver targeted electrical stimulation aimed at reducing cravings. Researchers measured craving levels and impulse control …

This study tested a new medicine called BXCL501 to see if it can safely reduce the unpleasant symptoms people feel when they stop taking opioids. 225 adults with opioid use disorder took part. The medicine was given as a film under the tongue, and researchers measured withdrawal …

This pilot study is testing whether a one-time, 45-minute virtual reality (VR) session guided by an AI coach can help people with chronic pain who also misuse opioids. The session includes a check-in, pain coping skills training, and a stress reduction exercise. The study involve…

This study tests a type of brain stimulation called accelerated theta burst stimulation (a form of TMS) to see if it can lower cravings for methamphetamine in people living with HIV. Thirty adults aged 18-65 with HIV and a history of meth use will receive the treatment. The goal …

This pilot trial tests whether adding microcurrent neurofeedback (MCN) to standard residential treatment helps adults with substance use disorder more than standard care alone. MCN uses scalp sensors to deliver barely perceptible electrical pulses tailored to each person's brain …

This study tests whether an AI chatbot called Suzy can help people recovering from opioid use disorder stay engaged with their care. Over 12 weeks, 55 participants will use the chatbot to prepare for appointments, find community resources, and learn coping techniques. Researchers…

This pilot study tested whether wearing bright light therapy glasses can improve sleep and reduce cravings in people being treated for opioid use disorder. Twenty-three adults on stable medication-assisted treatment (methadone or buprenorphine) with insomnia used either active or…

This study tests whether blocking the smell of cigarette smoke can reduce a smoker's desire to smoke. Participants wear a mask that delivers odor samples and rate how pleasant the smell is and how much they want to smoke. The goal is to see if odor blockers could become a new aid…

This pilot study tested an oral cannabinoid oil (CBD with a small amount of THC) in 51 adults with chronic pain. The goal was to see if it's practical to run a larger trial and to gather early data on pain relief and safety. Participants took the oil daily for up to 12 weeks, and…

This study tests whether inhaling medical cannabis three times a day can safely reduce pain in people with diabetic peripheral neuropathy. 122 adults will receive either a low, medium, or high dose of THC or a placebo using a special inhaler. The main goal is to see if pain score…

This study tests four virtual coaching sessions to help veterans with chronic pain use their own cannabis products more effectively. Participants will learn strategies to manage pain and related symptoms. The goal is to see if this coaching improves pain relief and satisfaction.

This study looked at whether adding medical cannabis to a behavioral program helps adults with long-term non-cancer pain lower their opioid dose and manage pain better. 87 participants on stable, high-dose opioids were randomly assigned to either start medical cannabis or not, wh…

This pilot study tested a smartphone app called SiS-H, designed to help people with HIV quit smoking. 66 participants were randomly assigned to use either SiS-H or a standard quit guide app. The study measured how often people used the app and how acceptable it was, rather than d…

This study tested whether a digital mindfulness app is practical and acceptable for people in early recovery from substance use disorders. 36 participants were randomly assigned to standard group therapy alone or standard therapy plus the app for 8 weeks. The main goal was to see…

This study tested whether a simple computer task, called the Approach Avoidance Task (AAT), could help smokers quit. The task aims to change automatic, unconscious thoughts that make people want to smoke. 52 daily smokers who wanted to quit took part. Researchers measured changes…

This study tested whether a computer joystick task that trains people to avoid smoking-related images can help them quit smoking when added to standard care. 96 daily smokers who wanted to quit participated. The training aimed to change automatic, unconscious tendencies to approa…

This study investigates whether an 8-week yoga program can help female smokers manage stress and nicotine withdrawal when trying to quit. Participants attend two 60-minute yoga sessions per week and provide hair and saliva samples to measure stress hormones. The goal is to see if…

This study tested whether a drug called isradipine, combined with virtual reality scenes of smoking, could lower cigarette cravings. 78 daily smokers took part. The goal was to see if this approach could help people quit smoking by reducing their urge to smoke when faced with tri…

This study tested whether a chatbot providing instant messaging support via WhatsApp could help adult smokers in Hong Kong quit. Over 1,000 participants received either brief advice plus chatbot support or brief advice alone. The goal was to see if the chatbot led to higher quit …

This pilot study tested whether an 8-week group therapy program delivered over Zoom could help adults with both chronic pain and opioid use disorder. The therapy, called Emotional Awareness and Expression Therapy (EAET), teaches people to understand and express their emotions as …

This study looked at whether adding a type of talk therapy called prolonged exposure therapy (PET) to standard opioid addiction treatment can help reduce PTSD symptoms. 82 adults with both opioid use disorder and PTSD took part. Some got only addiction treatment, while others als…

This study tested a type of group therapy called Resilience-Oriented Therapy (RoT) for adults in Rwanda who were struggling with mental health issues like trauma, depression, anxiety, or anger. 427 people took part, and the therapy was tailored to each person's main problem, such…

This study tested two brief, video-based therapies for women who experienced sexual assault and now struggle with PTSD and heavy drinking. One therapy focused on facing trauma memories, the other on building healthier drinking habits. The goal was to see if these short treatments…

This study tested a new type of counseling called behavioral activation problem solving (BAPS) against standard smoking cessation counseling for people with HIV in Botswana. 651 participants were split into two groups to see which approach helped more people quit smoking. The goa…

This completed trial tested a program called REDOCVR for 174 adults with chronic pain. The program combines group education, emotional support, and virtual reality experiences to help people reduce their pain medications. Researchers measured changes in medication use, mental wel…

This study tested whether low-intensity focused ultrasound (LIFU) can safely reduce cravings in people with cocaine use disorder. 25 adults received either real or fake (sham) ultrasound while their brain activity was measured with MRI. The goal was to see if LIFU lowers craving …

This small pilot study tested a culturally adapted group therapy called Emotional Awareness and Expression Therapy (EAET) in 6 Israeli adults with chronic musculoskeletal pain who also use medical cannabis. The goal was to see if the therapy could reduce pain and improve emotiona…

This study tested a telephone helpline designed to support people with opioid dependence. The helpline offered education, coping strategies, and referrals to medication-assisted treatment. Researchers enrolled 31 participants and measured satisfaction with the service. The goal w…

This study tested whether a smartphone app could help people with PTSD quit smoking and avoid starting again. Participants received counseling, stop-smoking medications, and rewards for not smoking, plus the app. The goal was to see if the app made it easier to stay smoke-free co…

This study tested whether a heart rate variability biofeedback program—using a sensor and smartphone app to guide slow breathing—is practical and helpful for adults in residential treatment for opioid use disorder. Thirty-two participants practiced daily for three weeks. Research…

This study tested whether adding a personalized therapy scale to standard treatment helps reduce cravings in people with substance use disorders or behavioral addictions like gambling. 151 adults seeking outpatient care participated. The approach aimed to tailor treatment to each…

This study tested a video-based program to help university students quit smoking. Participants recorded short videos about their reasons for quitting and received feedback from researchers. The goal was to see if this approach could reduce nicotine dependence and increase motivat…

This study looked at whether adding lofexidine to standard buprenorphine treatment can improve symptoms of both PTSD and opioid use disorder in veterans. 84 veterans on stable buprenorphine therapy were enrolled. The goal was to see if the combination reduced opioid use and PTSD …

This study tested whether offering payments for low carbon monoxide readings can help homeless smokers quit. Twenty-five homeless Veterans received nicotine replacement therapy, counseling, and a mobile phone to record their breath tests. The goal was to see if this reward-based …

This study tested a web-based program that combines cognitive behavioral therapy and pain self-management for people being treated for opioid use disorder who also have chronic pain. The program includes online lessons and daily text surveys to track pain and activity. Researcher…

This study looked at whether a 4-week circuit training program could improve heart and lung fitness in men recovering from drug addiction. Sixty men were split into two groups: one did circuit training (like push-ups, stair climbing, and high knees) three times a week, and the ot…

This study tested a smoking cessation program for caregivers of children admitted to American Family Children's Hospital. 23 caregivers received a 20-minute counseling session and used nicotine patches and lozenges for 2 weeks. The goal was to see if caregivers would use the prog…

This study tested a mobile app called OPY that helps patients manage pain and safely use opioids after surgery. Over 3,400 adults who had outpatient surgery and received an opioid prescription took part. The app provided daily tips, tracked pain and side effects, and encouraged p…

This study tested a breathing and meditation program called SKY Recovery in 100 people recovering from substance use disorder at a residential center. Participants either took the program right away or after a delay. Researchers measured changes in emotion regulation, cravings, a…

This early-phase trial tested whether deep transcranial magnetic stimulation (dTMS) targeting specific brain regions is safe and tolerable for people with moderate-to-severe cannabis use disorder. Twelve adults who used cannabis at least four days per week received the stimulatio…

This study looked at whether an online cognitive behavioral therapy program, called Breaking Free Online, helps people with substance use disorder cut back on their drug or alcohol use. About 200 adults from an outpatient addiction program took part. Some got standard care with g…

This pilot study tested whether adding exercise and pain-focused therapy to residential drug treatment is practical and helpful. 63 adults with opioid use disorder and pain took part. The goal was to see if they would stick with the program and if it could reduce pain, cravings, …

This study looked at whether listening to music can help lower cravings for opioids when people see drug-related cues. Twenty-eight adults with opioid use disorder, all on stable medication treatment, either listened to their favorite relaxing songs or sat in silence. Researchers…

This study tested whether a nerve block placed near the breastbone after heart surgery can reduce the need for opioid painkillers. 340 adults having heart surgery through a standard chest incision were randomly assigned to receive either the numbing drug ropivacaine or a saltwate…

This study tested whether a single dose of the antibiotic minocycline, given before guided memory recall, could reduce the strength of intrusive memories in people with PTSD or cocaine use disorder. 138 participants took either minocycline or a placebo and then imagined a persona…

This study looked at whether people with chronic pain and opioid use disorder would do art on their own at home, and if it helped their pain and mood. 31 adults tried self-directed artmaking up to four times. Researchers measured how many people stuck with it and whether anxiety,…

This study tested whether cytisine, a plant-based medication, is safe and helpful for quitting smoking in people who also have alcohol use disorder. Twenty adults who smoked daily and wanted to quit took part. The main goal was to see if the drug was well-tolerated and if partici…

This study looked at whether giving a tiny amount of the opioid remifentanil right after surgery could prevent a condition called opioid-induced hyperalgesia, where opioids actually make pain worse. It involved 41 women with breast cancer having breast surgery under total intrave…

This study tested whether transcranial magnetic stimulation (TMS) can help smokers quit by reducing cravings and preventing relapse. 88 adults who had failed previous quit attempts received daily TMS sessions for a week, followed by maintenance sessions. The goal was to see if th…

This study looked at a community-based program in Norway that helps people stop using cannabis. The program combines cognitive therapy and education over about 8 weeks. 102 people took part, and researchers measured changes in cannabis use, mental distress, and well-being right a…

This study tested a special type of talk therapy (cognitive-behavioral therapy, or CBT) delivered over telehealth to help veterans who feel lonely and struggle with substance use. The goal was to see if the program was practical and well-liked by participants. Thirty-six veterans…

This study tested a 9-session program that uses cognitive-behavioral techniques to help people living with HIV quit smoking by reducing anxiety and depression. 131 daily smokers who were motivated to quit took part. The goal was to see if the program led to more people staying sm…

This study created and tested a program to help teens and young adults (ages 14-21) who vape or smoke quit while they are in the hospital. 144 participants took part, and the program focused on helping them stop for at least 30 days. The goal was to see if this hospital-based sup…

This study tested whether peer-led therapy sessions could ease depression and anxiety in people recovering from opioid use disorder in rural areas. Forty adults receiving medication for opioid use disorder took part, with some getting extra support from a certified peer specialis…

This study tested whether a non-invasive brain stimulation technique called rTMS could reduce tobacco cravings in heavy smokers who had already failed multiple quit attempts. 39 highly nicotine-dependent adults received either real or fake rTMS to a brain region linked to craving…

This study tested a walking program for veterans with opioid use disorder and chronic pain. Sixty veterans receiving medication for opioid addiction took part. The program included pain education and a step-by-step walking plan using a pedometer. The goal was to see if this appro…

This study tested whether adding virtual reality (VR) to standard smoking cessation treatment helps people quit. 74 smokers who wanted to stop received nicotine patches and either usual counseling or VR-enhanced therapy. The goal was to see if VR could reduce cravings and improve…

This study tested whether taking melatonin for three nights before wisdom tooth surgery could lower pain and the need for pain medication afterward. Sixty adults aged 18-35 took either melatonin or a placebo before their surgery. Researchers measured how many pain pills they used…

This study tested whether inhaling lemongrass (as a vapor or from an inhaler) could reduce nicotine dependence and improve health markers in 200 adult smokers aged 18–30. Participants used lemongrass products or nothing (control) and provided blood samples and questionnaires. The…

This small pilot study tested whether cannabis oil (with different ratios of CBD to THC) could help with insomnia in people who also have major depression. Fourteen adults took either a high-CBD oil, a low-CBD oil, or a placebo for a short time. The main goal was to see if a larg…

This study tested a mindfulness-based treatment (MBRP) combined with cognitive behavioral therapy to help people reduce alcohol use and quit smoking. 67 adults who smoked and drank heavily participated. The goal was to see if the program was practical and satisfying for patients,…

This study tested a program called TOPPS for people taking buprenorphine for opioid addiction who also have chronic pain. The program uses counseling and education to help patients manage pain and avoid turning to substance misuse. 163 adults from primary care clinics took part, …

This study tested a new smoking cessation program for veterans who are at high risk for suicide. The program combines standard tobacco treatment with Dialectical Behavior Therapy (DBT), a therapy proven to reduce suicide risk. 67 veterans participated, and researchers measured ho…

This study tested whether giving nerve pain medications pregabalin or gabapentin alongside standard opioids could lower the amount of opioids needed by adults hospitalized with orthopedic injuries. 109 participants were randomly assigned to receive one of the two add-on drugs. Th…

This study tested whether suvorexant, a sleep medication, can reduce drug use and cravings while improving sleep and stress in people being treated for both opioid and stimulant use disorders. Twenty adults stable on methadone or buprenorphine took either suvorexant or a placebo …

This pilot study tested a mobile app called iCanChange in 100 young adults (ages 18-35) with psychosis and cannabis use disorder. The app uses motivational interviewing and cognitive behavioral therapy techniques through short interactive modules. The main goal was to see if the …

This study looked at whether a gentle brain stimulation technique called tACS can improve cognitive problems like memory and attention in people recovering from methamphetamine addiction. Researchers tested 68 participants using thinking tests, brain wave recordings, and blood sa…

This study tested a digital program called 'Empowered Relief: On-Demand' to see if it could help people with chronic pain who misuse prescription opioids. 234 adults with chronic pain and opioid misuse were randomly assigned to either the digital pain relief program or a health e…

This study tested a type of talk therapy called Positive Psychotherapy (PPT) to help people with serious mental illness quit smoking. Sixteen adults who smoked at least 10 cigarettes a day and wanted to quit took part. The goal was to see if at least 20% could stop smoking comple…

This study tested a short video and a 3-week text messaging program for adults who recently experienced sexual assault. The goal was to see if these tools could help prevent or reduce posttraumatic stress disorder (PTSD) and opioid misuse. Fifty participants received the video du…

This study tested whether CBD (a compound from cannabis) can help people who want to reduce their pain and opioid use. 126 adults took either CBD or a placebo for 12 weeks. Researchers measured changes in pain, opioid use, and other factors like anxiety and sleep.

This completed study looked at whether combining exercise with music can help people recovering from drug addiction. 92 adults in a Chinese rehab center were split into groups: exercise only, exercise with fast music, exercise with slow music, or a control group. Over six months,…

This study tested if chewing gum can help people smoke less or quit. 80 adults in Hong Kong who wanted to quit or cut down either used chewing gum or tried to quit on their own for one week. Researchers measured how much they smoked and checked their saliva to confirm if they had…

This early-phase study tested whether cannabidiol (CBD) could safely help people with both opioid use disorder and chronic pain. Seven adults on methadone or buprenorphine received single doses of CBD (400, 800, or 1200 mg) or a placebo in a crossover design. Researchers measured…

This study tested a mobile app called Support2Quit that uses a psychological technique called cognitive dissonance to help people stop smoking. The study enrolled 437 adult smokers who wanted to quit. Researchers measured how many people stopped smoking and how much they reduced …

This study tested whether a chatbot could help young smokers (up to age 25) quit tobacco. Over 150 participants used the chatbot as part of a youth quitline program. Researchers checked how many joined, stayed, and found it useful, and measured quit rates with saliva tests. The g…

This study tested a smartphone app that uses augmented reality to help reduce cravings to smoke. 14 adults who recently quit smoking tried the app and rated how easy it was to use and how much they liked it. The goal was to see if the app could be a helpful tool for quitting smok…

This study tested whether adding a specific breathing technique called diaphragmatic proprioceptive neuromuscular facilitation to aerobic exercise could improve lung function and exercise capacity in young adults (ages 20-29) who smoke heavily. Forty participants were split into …

This study looked at whether medical cannabis can reduce nerve pain and inflammation in people with HIV. Thirty-five adults with HIV and neuropathic pain used different ratios of THC and CBD over 14 weeks. Researchers measured changes in pain severity and blood markers of inflamm…

This study tested whether giving a single dose of pregabalin (Lyrica) before ureteroscopy—a surgery for kidney stones that often leaves a temporary stent in the ureter—can reduce pain and the need for opioid painkillers afterward. 118 adults were randomly assigned to receive eith…

This study tested a smartphone app designed to reduce anxiety and depression in people already receiving medication for opioid use disorder. 63 adults were randomly assigned to use the app for four weeks or to continue their usual care. The goal was to see if the app was feasible…

This study tested whether blocking a nerve cluster called the SPG can reduce withdrawal symptoms in people with opioid use disorder. Only 3 people took part, and the goal was to see if the approach is safe and worth studying further. It did not provide addiction treatment or medi…

This study looked at how cannabidiol (CBD) affects the brain in people with opioid use disorder who are also taking methadone. Researchers used brain scans to see if CBD could reduce cravings and anxiety. The study involved 66 adults and tested a single dose of CBD or a placebo, …

This study tested whether a type of brain stimulation called theta burst stimulation (TBS) could reduce cravings and attention to drug-related cues in 23 people with both opioid and tobacco use disorders. Participants received four sessions of real or fake TBS in one day while th…

This small, early-stage study tested whether a dietary supplement called palmitoylethanolamide (PEA) could help people with opioid use disorder feel less stress, craving, and pain. Twelve adults already on stable medication for opioid use took PEA or a placebo for three weeks. Th…

This study tested a smartphone app called OKquit to help smokers quit. About 500 adults who wanted to stop smoking were split into two groups: one got standard helpline support plus daily check-ins, and the other got that plus the OKquit app. The goal was to see if the app helped…

This small pilot study tested whether a 12-week supervised walking program could help middle-aged adults with opioid use disorder reduce pain and improve mobility. Only 6 people took part, and the main goal was to see if such a program was feasible—whether people would join and s…

This study tested whether suvorexant, a sleep aid, could help smokers manage cravings, withdrawal, and stress that often lead to relapse. Fourteen non-treatment-seeking smokers took the drug or a placebo and were monitored for stress reactions, smoking urges, and sleep quality. T…

Researchers at the American University of Beirut are studying whether the rate at which an e-cigarette emits nicotine, called nicotine flux, predicts how much nicotine reaches the body and how users feel. About 142 adult dual users of e-cigarettes and tobacco will use devices wit…

This study looks at how the labels and marketing claims on cannabis products affect what people think about the product's risks and effects. About 2,000 adults in states where recreational cannabis is legal will answer online survey questions after viewing a cannabis advertisemen…

This study looked at 23 adults going through alcohol detox to see how the bacteria in their mouth and gut change over time. Researchers collected stool and mouth samples along with diet and mood questionnaires. The goal was to better understand the link between gut bacteria, anxi…

This study looked at whether people with alcohol dependence or a history of early life stress have more trouble learning to feel calm after a scary event. Researchers used brain scans, mild electric shocks, and genetic tests to understand these differences. The goal was to learn …

This completed study looked at how genes influence addiction and related behaviors. Researchers collected blood samples and had 847 adults (healthy volunteers, smokers, drug users, and people with psychiatric disorders) complete questionnaires and computer tasks. The goal was to …

This study aims to create and improve cognitive tasks used during functional MRI scans to better understand how drugs affect the brain. It involves 525 healthy volunteers, including both drug users and non-users, aged 18 to 65. Participants perform tasks like memory tests or reac…

This study looked at how nicotine affects brain activity and genes in smokers and non-smokers. Researchers used brain scans and genetic tests to understand why some people find it harder to quit smoking. The goal was to find biological markers that could predict quitting success …

This study tested whether portable devices like PDAs and GPS units can give a more accurate picture of stress and drug use as it happens. About 373 adults in treatment for heroin addiction carried these devices for 16 weeks, recording drug use and stress levels. The goal was to s…

This completed study looked at how a person's neighborhood environment might influence drug use, addiction, and whether they seek treatment. Over 1,600 adults from Baltimore took part, including people who never used drugs, past users, and current users. Researchers collected hea…

This study measures two blood proteins, LRFN5 and OLFM4, in people with methamphetamine use disorder, those with methamphetamine-induced psychosis, and healthy volunteers. Researchers want to see if these markers are linked to inflammation and symptom severity. The study involves…

This study tested whether a remote, telehealth approach can work to study how cigarette filter ventilation (the tiny holes in the filter) affects smoking behavior and exposure to harmful chemicals. 64 adult smokers participated from home, using their own devices for video visits …

Researchers are studying how a full-spectrum medicinal cannabis plant extract with very low THC, called NTI164, moves through the body of healthy adult volunteers. The trial measures how much of the drug reaches the bloodstream and how much leaves the body in urine over up to 28 …

This study looks at how Salvation Army staff can help people who smoke learn about and use free quit-smoking services, like the Wisconsin Tobacco Quit Line. Researchers will train staff to offer a short survey that gives feedback on smoking risks and treatment options. The goal i…

This completed study looked at how 53 young adults (ages 21-34) who regularly vape perceive and react to e-cigarettes containing a new substance called metatine (6-methyl nicotine). Researchers measured how the body processes metatine, puffing behavior, sensory experiences, and a…

This completed study looked at how opioid use disorder changes dopamine signaling in the brain. Researchers used PET and MRI scans to compare people with opioid use disorder (some on medication, some not) to healthy volunteers. The goal was to understand differences in dopamine r…

This study looks at how stress changes the way opioid painkillers work in people with chronic back pain. Researchers will give participants oxycodone, a pain blocker, or a placebo in a lab setting to measure pain relief and drug liking. The goal is to understand why some people m…

This study looked at how adults who smoke cigarettes daily or only some days might react if certain tobacco products were no longer available. Researchers created a pretend online store where participants could shop for cigarettes and other nicotine products under different rules…

This study tested whether regular support calls can help veterans who are not ready to quit smoking to eventually stop. Over 500 veterans received either four calls a year (enhanced care) or one call a year (standard care). The goal was to see if more calls led to more quit attem…

This study looked at how sleep quality and beliefs about sleep affect the risk of relapse in people recovering from alcohol dependence. Researchers followed 198 adults as they left inpatient rehab and returned home, measuring sleep with questionnaires and activity monitors. The g…

This study looks at how different warning labels on cannabis edibles packaging change what people know, how safe they think the product is, and whether they want to try it. About 1,250 adults in the U.S. will view packages with different warnings and answer questions. The goal is…

This study investigates whether sleep duration and timing influence nicotine dependence, cravings, and withdrawal differently in Black and white smokers. Researchers will compare daily smokers and non-smokers, monitoring sleep with an Actiwatch and having participants undergo a s…

This study looks at whether older adults (55+) in methadone treatment for opioid use disorder can use smartphone-based cognitive games to track and possibly improve their thinking skills. Thirty participants will play short brain-training tasks twice a day for 15 days. The main g…

This study uses identical twins who both use cannabis to see if quitting for 42 days improves memory, attention, and mental health symptoms. One twin is paid to stop using cannabis, while the other continues as usual. Researchers will compare changes in thinking skills and mood b…

This study gives people with Cannabis Use Disorder drugs that mimic stress to see how it affects their desire for cannabis. Researchers measure brain activity and decision-making during four lab visits. The goal is to understand the link between stress and cannabis use motivation…

This study explores how transcranial magnetic stimulation (TMS) changes brain activity in people with and without heavy alcohol use. Researchers will use magnetoencephalography (MEG) to measure brain signals before and after TMS. The goal is to gather early data to support future…

This study follows 1600 adults with opioid use disorder over the long term by collecting monthly online surveys and yearly phone interviews. Researchers will track substance use, mental health, treatment involvement, and daily functioning. The goal is to better understand how peo…

This completed study worked with 65 African American/Black adults who use cocaine or other illicit substances to develop a manual called I-DREM. The goal was to gather their feedback on how to improve recruitment and retention in substance use disorder clinical trials. Participan…

This study looked at whether flavor chemicals in e-cigarettes can make them more addictive by changing brain function. 36 regular tobacco users (ages 21-60) had their brain activity measured while vaping, and their puffing behavior was tracked over 10 days. The goal was to unders…

This study explores whether compounds in cannabis, like THC and CBD, can reduce inflammation and improve how the body responds to insulin. Researchers will measure blood markers of inflammation and insulin sensitivity in people across the weight spectrum, both after a single use …

This study investigates how three weeks of cannabis abstinence influences brain responses to threat, reward, and cannabis cues in women with cannabis use disorder. Participants are randomly assigned to either continue using cannabis as usual or abstain for three weeks, with lab v…

This study looks at how different e-cigarette flavors appeal to adults who have opioid use disorder and are on buprenorphine treatment. Participants will smell and rate 11 flavors for sweetness, coolness, strength, and how likely they'd use them again. The goal is to find flavors…

This completed study tested whether targeted brain stimulation (TMS) could affect attention and nicotine cravings in 15 people with schizophrenia or schizoaffective disorder who smoke. Researchers applied different types of TMS to a brain network linked to attention and measured …

This study tested a computer tool designed to help emergency room doctors follow best practices for treating opioid use disorder. Researchers looked at whether the tool increased the use of standard assessments and buprenorphine treatment. The study involved 267 adults with moder…

This study aims to create a better tool for measuring opioid cravings in people being treated for opioid use disorder. Researchers will show participants opioid-related images and objects, then interview them about their feelings and thoughts. The goal is to improve how cravings …

This study tested how tobacco-free nicotine pouches affect the body and mind compared to regular cigarettes. Seventy-one adult smokers tried different doses and flavors of pouches, as well as their own cigarettes, in a controlled setting. Researchers measured nicotine levels in t…

This study looked at how different marketing messages about tobacco-free nicotine pouches affect what people think about them. Over 5,000 participants in the US, including smokers and young non-users, answered survey questions after seeing ads. The goal was to understand how word…

This study tested two methods to encourage COVID-19 testing among people who use opioids: having friends refer others (chain referral) and using trusted community members (credible messengers). About 500 people took part. The goal was to see which method got more people tested an…

This trial investigates whether smoking or vaping cannabis increases the frequency of premature atrial and ventricular contractions — early or extra heartbeats that can feel like skipped beats. Over 14 days, regular cannabis users will be randomly assigned to consume or avoid can…

This study looked at how a specific way of thinking, called high-level construal (focusing on the big picture), affects smoking habits. Researchers studied 300 low-income adults aged 25-55 who wanted to quit but had failed before. They used brain scans and surveys to see if this …

This study tests whether suvorexant (Belsomra), a sleep medication, can lower brain activity linked to cannabis cravings. Twenty adults who use cannabis daily will take the drug for 14 days and undergo brain scans before and after. The goal is to see if the medication reduces the…

This study tested a harm reduction program designed specifically for Black adults who misuse opioids or stimulants. 63 participants completed surveys before and after the program to see if their knowledge, confidence, and willingness to use overdose prevention techniques improved…

This study looked at how three psychological treatments—cognitive therapy, mindfulness meditation, and behavioral activation—might help adults with chronic pain reduce their use of opioid medications. Researchers enrolled 91 people with chronic pain who were at risk of opioid mis…

This study explored whether experiencing subtle racial slights (microaggressions) makes Latinx smokers want to smoke more or makes it harder to quit. Thirty daily smokers who identified as Hispanic or Latino took part. Researchers measured their smoking behavior, withdrawal sympt…

This study looks at 65 veterans with PTSD who use cannabis frequently. Researchers want to see if reducing cannabis use improves their daily functioning, mental health, and quality of life. No treatment or drug is given—participants simply report their cannabis use and well-being…

Sleep problems affect up to 90% of people with alcohol dependence and often lead to relapse. This study tests whether a short questionnaire called the Short Sleep Index (SSI) can reliably measure sleep quality compared to a longer, standard sleep questionnaire. Researchers will a…

This study from Yale University looked at how menthol flavor in e-cigarettes affects smoking behavior and nicotine levels in people who smoke menthol cigarettes. Fourteen adult smokers participated in lab sessions where they used e-cigarettes with menthol or non-menthol flavor. R…

This study tests whether recalling a positive memory can improve mood and decision-making in 80 adults recovering from methamphetamine use disorder. Participants will do computer tasks and brain scans before and after remembering a happy event or a neutral memory. The goal is to …

This study tested a program designed to make medication for opioid use disorder more culturally appropriate for American Indian and Alaska Native communities. Researchers worked with four healthcare sites to help them better support patients starting and staying on these medicati…

This study looked back at the records of 652 patients who were seen in the emergency department of a French hospital and then referred to a special addiction liaison team. The goal was to understand the social and medical backgrounds of these patients. The findings could help hos…

This completed study looked at 59 men who have sex with men and use methamphetamine. Researchers used a program that gives rewards for drug-free urine samples to help them cut back. They measured inflammation in the rectum and tracked STI/HIV risk behaviors over 8 weeks. The goal…

This study investigates whether chronic cannabis use impairs contrast sensitivity — the ability to see objects clearly against their background, especially when they are moving. Researchers will compare three groups: cannabis addicts, tobacco-only smokers, and non-smokers. Partic…

This study looked at whether opioid use disorder and non-fatal overdoses cause a harmful protein called tau to build up in the brain. Researchers used special PET/CT scans on 12 adults, including those with opioid use disorder and healthy volunteers. The goal was to understand lo…

This study tested a training program for prenatal healthcare providers to help them use medication-assisted treatment (MAT) for opioid use disorder during pregnancy. Researchers looked at data from over 1,000 patients to see if the program increased use of MAT and improved health…

This completed study surveyed over 1,500 adults in Nyakabare Parish, Uganda, to learn how people perceive tobacco and alcohol use in their community. Participants answered questions about how often they think others smoke or drink. The goal was to understand perceived norms, whic…

This completed study examined how African American and white male smokers respond to stress and how that affects their smoking habits. Researchers used a psychological stress test and measured daily cortisol patterns to understand biological differences. The goal is to learn why …

This study combined brain imaging with real-world data from mobile devices to explore how addiction affects the brain. Researchers scanned the brains of 107 people with alcohol, cannabis, or nicotine dependence, along with healthy controls. They also tracked cravings and daily fu…

This study looked at how different labels on vaping devices (like 'contains nicotine' or 'high potency') affect teens' interest in trying them, their views on health risks, and what effects they expect. Over 3,000 high school students viewed images of vaping devices with various …

This study looked at brain activity in pregnant women with opioid use disorder who were taking medication therapy. Researchers compared their brain scans to those of healthy pregnant women to see if there were differences. The goal was to learn more about how the body processes t…

This study looked at whether changes in a person's voice can help detect opioid use in people being treated for opioid use disorder. Researchers collected voice samples from 41 patients and used machine learning to find patterns linked to opioid intoxication or withdrawal. The go…

This study tested whether a mobile app could help people on probation or parole who are receiving treatment for substance use disorder. 31 adults used the app alongside their usual care. Researchers measured how easy the app was to use and how satisfied participants were with it.

This study looked at how opioid maintenance therapy affects sensation, balance, walking, posture, and reaction time in people with opioid use disorder. Researchers compared 80 adults on buprenorphine/naloxone therapy to healthy individuals. They measured things like foot sensatio…

This observational study looked at how legal cannabis use changes alcohol drinking habits, gut bacteria, and brain function in people who regularly use both alcohol and cannabis. 77 heavy drinkers who also smoke cannabis took part, providing blood and stool samples and completing…

This study tested whether a training program called Modeling to Learn (MTL) helps clinic staff improve how many veterans start and finish evidence-based treatments for PTSD, depression, and opioid use disorder. The program uses computer simulations to let staff try out changes to…

This study looked at how different types of cannabis affect memory and brain waves in 96 healthy adults who use cannabis regularly. Participants did a memory task after smoking cannabis and again on a sober day, while their brain activity was recorded with EEG. The goal was to se…

This study looked at how the supplement n-acetylcysteine (NAC) affects brain glutamate levels and drug cravings in 12 people who use both opioids and cocaine. Participants were given either NAC or a placebo while on a steady dose of hydromorphone, and then underwent brain scans a…

This study looked at how two hormones that rise during pregnancy—estradiol and cortisol—affect the way the body breaks down THC, the main active ingredient in cannabis. Fourteen healthy women of childbearing age took part. Researchers measured THC levels in the blood after taking…

This study tested a special parenting program (mABC) for pregnant women recovering from opioid addiction. 174 mothers and their babies took part. The program focuses on helping mothers be more sensitive and nurturing, which could improve the baby's emotional and physical developm…

This study involved 24 adult smokers who used three different nicotine products: a tobacco-free nicotine stick, a heated tobacco stick, and regular cigarettes. Researchers measured how much nicotine entered the blood and how the body processed it. The goal was to understand the d…

This study looked at how hospital doctors, nurses, and social workers feel about treating opioid use disorder (OUD) while patients are in the hospital. Researchers surveyed 400 healthcare workers across 12 hospitals in Colorado. The goal was to understand current practices and se…

This study looked at whether using regular patient surveys to guide treatment can help people with opioid use disorder stay in treatment and stop using opioids. Researchers worked with 35 clinic leaders and providers to train them on this approach. They compared patient attendanc…

This study tested whether a drug called SXC-2023 interacts with cocaine in the body. Nineteen adults who use cocaine but were not seeking treatment took part. Researchers measured side effects and vital signs like heart rate and blood pressure after giving cocaine. The goal was t…

This study looked at how smoking marijuana with different levels of THC affects alcohol cravings and drinking in people who are heavy drinkers and also use marijuana. 157 participants were given either a high-THC, moderate-THC, or placebo marijuana cigarette, then their alcohol c…

This study tested a mobile app called App for Independence-O (A4i-O) designed to support people with opioid use disorder. Fourteen adults used the app for one month while receiving outpatient treatment. The goal was to see if the app works well and is easy to use, not to measure …

This study tested a group well child care program for mothers in treatment for opioid use disorder and their infants. Instead of standard one-on-one checkups, mother-infant pairs attended group visits together from 1 to 18 months of age. The goal was to see if this approach impro…

This study involved 440 daily smokers and dual users (smokers who also vape) to understand how price changes affect their choices between cigarettes and other nicotine products like e-cigarettes, nicotine pouches, and heated tobacco. Participants completed a simulated shopping ta…

This completed Phase 1 study looked at how marijuana and an opioid drug influence each other's use in healthy adults aged 18-50 who had experience with both substances. Eight participants lived at a research unit for about 6.5 weeks and could earn doses of each drug under control…

This study tested a digital version of a family training program called CRAFT. It was designed to help concerned family members (called CSOs) encourage a loved one with opioid use disorder to enter treatment. 45 adults who had a loved one struggling with opioid use participated. …

This study tested whether an anti-stigma training program for healthcare providers improves attitudes toward people with mental illness or substance use problems. About 485 staff and clients from six health centers took part, with three centers receiving the training and three no…

This study looked at the best ways to bring FDA-approved digital treatments (reSET and reSET-O) for opioid and other substance use disorders into primary care clinics. Over 18,000 adults who screened positive for substance use took part. Researchers tested whether health coaching…

This study looked at how a single dose of methamphetamine affects the HIV virus in people who are already on effective HIV treatment. Fourteen HIV-positive adults with no history of meth use took part. The goal was to see if meth causes the virus to become more active and increas…

This completed study looked at how regular cannabis use affects brain health and thinking skills in people with HIV and those without. Researchers used brain scans, blood and spinal fluid tests, and thinking tasks to compare 276 participants. The goal was to understand the combin…

This small, early-phase study tested whether a single dose of sedatives like ketamine, midazolam, or dexmedetomidine could reduce cigarette cravings and smoking in 20 daily smokers. Participants received one of these drugs or a placebo (saline) and reported their cravings, withdr…

This study looked at how nicotine is absorbed and affects the body when using a standardized research e-cigarette compared to a person's usual brand e-cigarette. Thirty-two regular e-cigarette users participated in a crossover study where they used both types. Researchers measure…

This completed study from the University of Hong Kong looked at 110 cannabis users aged 16-60 to see how their thinking skills change over time and if genes play a role. Participants took memory and thinking tests and gave blood for genetic analysis. The goal is to understand lon…

This study measured how much nicotine gets into the blood and how smokers feel after using heated tobacco products, regular cigarettes, or nicotine gum. Eighty adult smokers took part in a six-day clinic stay where they tried each product. The goal was to understand the appeal an…

This completed Phase 1 study at UCLA looked at how smoking cannabis with different amounts of THC and CBD affects drug levels in oral fluid and blood, as well as thinking and feeling. Nineteen adults who use cannabis occasionally took part. The goal was to better understand how t…

This study looked at how smoking affects a brain chemical called glutamate in men versus women. Researchers scanned the brains of 58 smokers after not smoking overnight and after their first cigarette of the day. They also measured hormone levels in women to see if hormones influ…

This study looked at 385 adults diagnosed with their first lung or head & neck cancer to see how many continued using tobacco or alcohol over the next year. Researchers tracked smoking and drinking habits, as well as how long patients lived without the cancer getting worse. The g…

This study looked at pregnant women being treated for opioid use disorder with two different forms of buprenorphine: a monthly shot and a daily tablet. Researchers measured drug levels in the mother's blood and checked the baby's heart rate to see how each treatment affected both…

This study looked at 71 babies born to mothers who took either a monthly injection or a daily tablet of buprenorphine for opioid use disorder during pregnancy. Researchers measured the babies' thinking, language, and motor skills using a standard child development test. The goal …

This study explored whether how addicted a person is to nicotine affects their awareness of having gum disease. Researchers examined 350 smokers with gingivitis or periodontitis, measuring their nicotine dependence with a standard test and asking about their gum health. The goal …

This study looked at whether little cigars and cigarillos (LCCs) are addictive, especially when flavored like fruit, and if addiction differs between men and women. Researchers studied 65 young adults aged 18-34 who smoke both LCCs and cigarettes. They measured how much people wo…

This study looked at how the amount of sugar in cigarette tobacco affects how much people enjoy smoking and how addictive the cigarettes seem. Thirty adult smokers tested cigarettes with different sugar levels and answered questionnaires about their experience. The goal was to se…

This study tested a program called CRAFT-EP, which helps families support a relative with early psychosis and substance use (like alcohol or cannabis). The program was delivered entirely through video calls. Researchers measured family members' depression and anxiety to see if th…

This study measured a specific enzyme in the blood of 93 people to see if it is linked to psychotic symptoms in methamphetamine users. Participants included people with methamphetamine use disorder, those with methamphetamine-induced psychosis, and healthy volunteers. The goal wa…

This study measured harmful chemicals in the air after adults used either a heated tobacco product (ploom) or regular cigarettes in a sealed room. Researchers tracked over 20 pollutants like nicotine, formaldehyde, and benzene. The goal was to see how the two products differ in s…

This study looked at whether a questionnaire called the Behavioral Activation for Depression Scale (BADS) is a good tool for measuring depression-related behaviors in people with substance use disorders. Researchers analyzed answers from 289 adults receiving treatment for substan…

This completed study with 65 adult smokers and vapers tested how different rules and penalties affect whether people buy illegal tobacco products. Participants used a simulated store to see how promotion factors and mitigation strategies like fines changed their buying choices. T…

This study looked at ways to prevent tuberculosis (TB) in Malaysian prisoners, many of whom also had HIV, opioid addiction, or hepatitis. Researchers compared a standard 40-week TB prevention treatment with a shorter 12-week option. The goal was to see which approach worked bette…

This study looked at whether cannabis use affects sperm quality in infertile men. Researchers compared sperm samples from 71 men who used cannabis and those who did not. They measured sperm DNA health and other factors to see if cannabis might be linked to fertility problems.

This study looked at how a pill form of THC (dronabinol) affects sleep and thinking in 18 adults. Some participants used cannabis frequently (more than 3 times a week), while others rarely used it (less than 10 times ever). Researchers measured sleep stages, alertness, memory, an…

This pilot study tested whether a computer avatar that delivers a smoking cessation program, combined with help from a community health worker, could help people in Baltimore public housing quit smoking and get screened for lung cancer. Ten adults aged 50 or older who smoked took…

This completed study at Yale University looked at how 66 adult smokers (ages 21-44) perceive sweet, cooling, and unflavored e-cigarette liquids. Participants tried each flavor and rated its appeal, sensory effects, and how much they wanted it compared to money. The goal was to se…

This completed study tested different strategies to help emergency doctors start buprenorphine treatment for people with opioid use disorder. Researchers used a computer system to prompt nurses and doctors, and gave patients educational materials. The goal was to see which combin…

This study tested a Spanish-language electronic screening tool called TAPS-ESP to identify tobacco, alcohol, prescription drug, and illicit substance use in primary care. About 1,000 Spanish-speaking adults from a clinic participated. The goal was to see if the tool accurately de…

This completed study looked at 12 people with opioid use disorder who had been stable on SUBLOCADE injections for at least 9 months. Researchers wanted to see if they could successfully stop the medication without relapsing or restarting long-term treatment. The goal was to under…

This study looked at whether a strong sense of 'presence' during virtual reality therapy could help people with alcohol dependence manage cravings and avoid relapse. Sixty abstinent patients who had recently completed withdrawal treatment took part. Researchers measured craving l…

This study tested a new way to help addiction treatment clinics use an AI platform that coaches counselors in evidence-based techniques. Researchers worked with 479 leaders and staff from state agencies and clinics in Oregon and Indiana. The goal was to see if this strategy impro…

This study tested a new brain-training method to help people with heroin addiction reduce cravings. Participants watched drug-related videos while getting real-time feedback on their brain activity, learning to match the brain patterns of people further along in recovery. The goa…

This study tested whether a genetic biomarker called the Nicotine Metabolite Ratio (NMR) can help doctors choose the best FDA-approved smoking cessation medication for each person. 82 daily smokers were assigned to varenicline, bupropion, or nicotine patches based on their NMR re…

This study looked at whether people who inject opioids can safely finish a course of IV antibiotics at home instead of staying in the hospital. Ten participants received home antibiotic therapy along with addiction medication and support from a health coach and case manager. The …

This study looked at how warning labels on little cigars and cigarillos (LCCs) affect teens aged 15-20 who have used or might try them. Researchers surveyed 928 participants to measure their willingness to use LCCs and how often they used them. The goal is to help the FDA create …

This completed study looked at whether six new nicotine oral products (pouches in flavors like cool mint and dragon fruit) are less addictive than regular cigarettes. Forty adult smokers tried each product in a controlled clinic setting. Researchers measured how much participants…

This study tested a patient decision aid designed to help adults with opioid use disorder choose the best medication-assisted treatment for them. Over 7,500 people took part, and researchers tracked their drug use, treatment retention, and health outcomes for up to 24 months. The…

This study looked at how flavors in e-cigarettes affect how much adult smokers like and want them. It included 130 smokers aged 21-50 who used only e-cigarettes for two weeks. The goal was to measure their reactions, not to treat or cure any condition.

This study looked at 40 people who used cannabis within a month before surgery. Researchers used a bedside ultrasound to measure stomach contents and volume, checking if cannabis use leads to delayed stomach emptying. The goal was to better understand how cannabis might affect su…

This study tested two types of brain stimulation (TMS) in 90 people who smoke, half with schizophrenia and half without. The goal was to see if TMS could change brain connections and reduce nicotine cravings. Participants completed thinking tasks and reported their cravings befor…

This study looked at whether adults with ADHD are more likely to relapse into drinking after completing a detox program. Researchers followed 113 people for 12 weeks, using interviews and questionnaires to assess ADHD and other mental health conditions. The goal was to see if ADH…

This study looked at whether cannabis or a similar drug (dronabinol) can improve brain reward function in people with schizophrenia who also use cannabis. 263 participants took part to see if these substances help regulate brain circuits linked to motivation and pleasure. The goa…

This completed study surveyed 257 adults with sickle cell disease to understand how they use painkillers at home, including opioids and cannabis. Researchers wanted to find out how common opioid addiction is in this group. Patients answered a one-time questionnaire at three speci…

This study tested whether a mental exercise called Episodic Future Thinking (EFT) could change how people with cocaine use disorder make decisions and reduce their cocaine use. 141 participants were asked to vividly imagine positive future events or control events. Researchers me…

This study looked at how cannabis affects memory in people who use it regularly. 121 participants inhaled either a low or high dose of cannabis, or a placebo, and then took a series of memory tests. The goal was to see if cannabis makes it harder to remember things like words, pi…

This study looked at how the strength and form of nicotine in e-cigarettes affect how fast and how much nicotine gets into the blood. Thirty-six adults who vape regularly took puffs from different e-cigarette setups while their blood was sampled through a small tube in their arm.…

This study looked at how drinking alcohol and using high-THC cannabis concentrates together affects people. 146 heavy drinkers who also use cannabis regularly took part. Researchers measured things like blood alcohol level, heart rate, and how impaired they felt, depending on whe…

This study tested a program called Care Coordination after Preterm Birth (CCAPB) to see if it helps mothers who had a preterm baby. The program provides extra support with healthcare access and well-being for six months. Researchers measured how acceptable the program was and its…

This completed Phase 1 study at Yale University looked at how vitamin D (calcitriol) affects dopamine receptors in the brains of people with opioid use disorder. Five participants received either vitamin D or a placebo and had PET scans to measure brain activity. The goal was to …

This study looked at how sex hormones and gender influence recovery from cannabis use disorder. 224 adults who wanted to cut down on cannabis received 8 weeks of counseling, including one-on-one goal setting and computerized therapy. They also provided daily saliva samples to tra…

This study looked at how to help more veterans with opioid use disorder get effective medication. Researchers combined six pilot projects across 63 VA sites to find the best ways to increase access to these treatments. The goal was to see if a structured support program for healt…

This completed study looked at how nicotine salt-based vaping products compare to free-base nicotine e-liquids. Fifteen daily vapers tried different flavors and nicotine levels, and researchers measured nicotine levels in their blood and asked about harshness and satisfaction. Th…

This study developed a computer program that can scan hospital records to find patients who may be misusing drugs or alcohol. Researchers tested it on nearly 65,000 adults admitted to the hospital. The goal was to see if the tool could help doctors offer counseling and support to…

This study looked at how cannabis use affects brain receptors and electrical activity, and how these change when people stop using. Researchers used brain scans and EEGs in 162 people, including cannabis users and healthy controls. The goal was to understand the brain's recovery …

This study, completed by Yale University, tested whether a standardized field test can measure marijuana impairment in drivers. 41 participants who use marijuana regularly completed cognitive tasks and simulated driving after smoking either medium-THC or placebo marijuana. The go…

This study tested how limiting flavors in cigarettes and e-cigarettes changes what people choose to buy. 302 adult smokers completed a single online session where they made purchases in a simulated tobacco marketplace. Researchers measured how much of their budget they spent on c…

This study tested whether sending letters to doctors about their patients' opioid overdoses would reduce how often they prescribe strong painkillers. Researchers looked at 61 clinicians who had prescribed opioids to patients who later had a non-fatal or fatal overdose. The goal w…

This study tested a program that brings in family and friends to support people receiving methadone treatment for opioid use disorder in Tanzania. The goal was to see if this social support approach is acceptable and practical, and whether it helps people stick to their methadone…

This study looked at whether brain signals and thinking skills can predict how well Veterans with cocaine addiction respond to a behavioral therapy called contingency management. In this therapy, patients earn chances to win prizes for providing cocaine-free urine samples. The go…

This study looks at whether a patient navigation program can help more people with opioid use disorder start treatment after being in the hospital. The program, called NavSTAR, was tested in 4 Philadelphia hospitals with 32 patients. The goal is to learn how to make this program …