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Could cannabis oil ease chronic pain? small trial aims to find out

NCT ID NCT05351905

Symptom relief Sponsor: University Health Network, Toronto Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jul 23, 2026 · Updated 3 times

Summary

This pilot study tested an oral cannabinoid oil (CBD with a small amount of THC) in 51 adults with chronic pain. The goal was to see if it's practical to run a larger trial and to gather early data on pain relief and safety. Participants took the oil daily for up to 12 weeks, and researchers tracked how many people completed the study and how well they stuck to the treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
CBD oil (MPL-001) with a small amount of THC
What this could lead to
If successful, this could point toward a new treatment option for chronic pain that may help reduce opioid use.
What could go wrong
This is a small pilot study with only 51 participants, so results may not apply to everyone. It is designed mainly to test feasibility, not to prove the treatment works.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

51 people

The number who actually took part.

Started

Nov 2022

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

25 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age ≥ 25 years 2. Able to understand and read English 3. Experiencing chronic, non-palliative pain Exclusion Criteria: 1. Use of nabilone, nabiximols or cannabis in the 30 days preceding study recruitment 2. Known allergy to cannabis or any cannabinoid 3. Serious ongoing medical issues (i.e., lung, liver, kidney or heart disease) that in the opinion of the Investigator would compromise the safety of the patient 4. Current uncontrolled serious mental disorders such as schizophrenia, or psychosis 5. Currently pregnant or breast-feeding (a negative urine pregnancy test must be obtained for women of child bearing potential during pretreatment evaluation) 6. Men and women planning to start a family in the next 12 weeks 7. Has declared a current alcohol or substance use disorder (excluding opioid use disorder) 8. Currently using Methadone or Buprenorphine 9. Patients who are naïve to pain treatments

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Conditions

The condition(s) this trial relates to.

cannabis dependence Chronic Pain chronic pain syndrome opioid abuse

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cannabis Chronic pain Opioid use

Contacts and locations

Locations

  • University Health Network

    Toronto, Ontario, M5G 2C4, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.