Brain zaps curb smoking cravings in hardcore nicotine addicts
NCT ID NCT02812810
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether a non-invasive brain stimulation technique called rTMS could reduce tobacco cravings in heavy smokers who had already failed multiple quit attempts. 39 highly nicotine-dependent adults received either real or fake rTMS to a brain region linked to craving, alongside nicotine replacement therapy. The goal was to see if adding rTMS could improve success rates for quitting smoking.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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39 people
The number who actually took part.
- Start date
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Sep 2011
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adult 18-65 years old * Wishing to stop smoking * Highly dependent on nicotine (score ≥ 7 on the Fagerström self-questionnaire) * History of at least 2 failed attempts to stop smoking despite recommended treatments (nicotine, vareniciline, bupropion) Exclusion Criteria: * Abstinence in the 3 previous months * Absence of effective contraception for women * Progressive chronic disease * Ongoing psychiatric disorders * Current addiction to other substances or cessation of less than one year * Current treatment with psychotropic agents * Epilepsy and other contra-indications for rTMS (pacemaker, metallic clips or other electronic implants, head trauma, intracranial hypertension). * Contra-indications for transdermal nicotine substitutes (recent myocardial infarction, unstable or worsening angina, Prinzmetal angina, severe heart rhythm disorders, recent stroke, skin disorders that could interfere with the use of transdermal treatments, hypersensitivity to one of the constituents). * Personnel working in the psychiatric and addictology unit of the CHU (conflict of interest)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Centre Hospitalier Universitaire
Dijon, 21079, France
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Other studies related to the condition(s) this trial covers.
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