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Meth reduction may lower STI risk, small study suggests

NCT ID NCT05162391

Knowledge-focused Sponsor: University of California, Los Angeles Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study looked at 59 men who have sex with men and use methamphetamine. Researchers used a program that gives rewards for drug-free urine samples to help them cut back. They measured inflammation in the rectum and tracked STI/HIV risk behaviors over 8 weeks. The goal was to understand if reducing meth use lowers infection risk.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Contingency management (behavioral intervention with incentives for drug-free urine samples)
What this could lead to
If successful, this could help design better programs to reduce meth use and lower STI/HIV risk in this population.
What could go wrong
This is a small, completed observational study without a control group, so results may not apply broadly. It does not test a new drug or treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

59 people

The number who actually took part.

Started

May 2022

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Male participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Cisgender male * 18 years of age or older * Understand written and spoken English * Condomless receptive anal intercourse in past 90 days * Meet DSM-5 criteria for methamphetamine use disorder * Positive urine toxicology screen for MA metabolites at study entry * Negative rectal GC/CT screen (n=20) or Positive rectal GC and/or CT screen (n=20) * Able to provide written informed consent and willing/able to complete study visits. Exclusion Criteria: * Reports current treatment for another substance use disorder * Positive test for opioids, cocaine, and/or hallucinogens * Treatment for gonorrhea and/or chlamydia infection in past 3 months * Presence of a condition that in the opinion of the investigator would compromise the safety of the patient or the quality of the data

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Conditions

The condition(s) this trial relates to.

chlamydia infectious disease chlamydia trachomatis infectious disease gonorrhea methamphetamine dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Methamphetamine-dependence Rectal chlamydia Rectal gonorrhea

Contacts and locations

Locations

  • UCLA Vine Street Clinic

    Los Angeles, California, 90038, United States

More trials for these conditions

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