Can a device replace pills for opioid withdrawal?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 18 and 65 years old * Meets Diagnostic and Statistical Manual-5 criteria for Opioid Use Disorder (OUD) (moderate or severe) based upon Mini-International Neuropsychiatric Interview (MINI) * Provides a urine sample that tests positive for opioids during screening or have evidence of opioid withdrawal * Be in good general health based on a physical examination, medical history, vital signs, and screening urine and blood tests * No significant psychiatric illnesses besides OUD * Seeking treatment to stop using illicit opioids * Willing to comply with the study protocol * Have no clinically significant chronic medical or surgical disorders or conditions that are judged by the investigators to prevent participation Exclusion Criteria: * Pregnant or breast feeding * Receiving opioid agonist treatment * Significant medical illness (e.g., insulin dependent diabetes) * Significant psychiatric illness (e.g., schizophrenia) * Use of medical cannabis * Contraindications for use of the Bridge Device, morphine, lofexidine or naloxone (e.g., hemophilia, psoriasis and other skin conditions, a cardiac pacemaker) * Have evidence of physical dependence on alcohol or benzodiazepines that requires medical detoxification * Hypotension (diastolic blood pressure of less than 60 mm Hg or systolic blood pressure of less than 90 mm Hg on screening examination) * Prolonged corrected QT interval interval on screening ECG (defined as \>0.44 seconds for males and \>0.46 seconds for females) * Hepatic or renal impairment, as indicated by the following lab results at the screening session: * Aspartate aminotransferase or alanine transaminase \>3x upper limit of normal (ULN) * Total Bilirubin \>2x ULN. * Creatinine \>1.5x ULN. * Treatment with a strong 2D6 inhibitor (e.g., paroxetine, thioridazine, cinacalcet, bupropion, methotrimeprazine, fluoxetine, midostaurin, propafenone, glycerol phenylbutyrate, halofantrine, cisapride, dacomitinib, orphenadrine, quinidine) * Have a known allergy to any of the study medications * Have circumstances that would interfere with study participation (e.g., impending jail)